Serum Cardiac Troponin I Concentrations in Dogs with Systemic Inflammatory Response Syndrome

Abstract

BackgroundMyocardial injury can be detected by cardiac troponin I (cTnI) concentration, which appears to be a predictor of short‐term death in critically ill patients. It is unknown if the best prognostic indicator of short‐term survival is cTnI measurement at admission or at later time points.Hypothesis/ObjectivesMeasuring cTnI with a high‐sensitivity (HS) test at different time points after admission may be a better short‐term prognostic indicator than a single cTnI measurement at admission in dogs with systemic inflammatory response syndrome (SIRS).AnimalsProspective, observational clinical study of 60 dogs with SIRS.MethodsCardiac troponin I concentration was measured in 133 serum samples, collected at days 1, 2, 3, and 5. Additionally, the acute patient physiologic and laboratory evaluation (APPLE) fast score was evaluated at admission. Prognostic capabilities of cTnI measurement and APPLE fast score for 28‐day mortality were assessed by receiver operating characteristic curve analysis.ResultsForty‐one dogs with SIRS that survived 28 days had significantly lower serum cTnI concentrations at admission (median, 0.09 ng/mL; P = .004) and at the peak time point (median, 0.23 ng/mL; P = .01) compared to 19 nonsurvivors (median at admission, 0.63 ng/mL; median at peak, 1.22 ng/mL). Area under the curve to predict survival, using cTnI was similar at admission (0.732) and at peak (0.708), and was 0.754 for the APPLE fast score.Conclusions and Clinical ImportanceIncreased cTnI concentration in dogs with SIRS is associated with poor outcome. Daily follow‐up measurement of cTnI concentration provides no additional prognostic information for short‐term mortality.

Seric Concentration of Troponin I and Electrocardiographic Tracing in Dogs Submitted to Long-Term Sedation during 24 Hours

“…O valor da cTnI comumente encontrado para cães hígidos é 0,03 ng/mL [10], porém, valores de 0,06 e 0,07 ng/mL [21,25] e até valores limites de 0,16 ng/ mL [22] são citados como normais. Diferentes méto-dos de aferição detêm diferentes valores de referência [1], visto que a detecção limite pode variar entre estes métodos.…”

Troponina I como biomarcador de lesão cardíaca em cães com sepse

“…Quando ocorre um dano à célula do miocárdio, a troponina é liberada na circulação e pode ser mensurada por meio de métodos de imunoensaio (Hamacher et al, 2015;Sheyin et al, 2015;Tiruvoipati et al, 2012). No atual estudo, as concentrações séricas da troponina I cardíaca não demonstraram diferença estatística significativa entre o grupo controle e o grupo piometra sepse ou não sepse, diferindo de Pelaner et al (2008), em que houve diferença significativa na concentração da troponina I em cadelas com piometra se comparadas ao grupo controle.…”

“…A troponina I é uma proteína encontrada em fibras musculares esqueléticas e cardíacas responsáveis pela contração muscular (Hamacher et al, 2015;Sheyin et al, 2015;Tiruvoipati et al, 2012). A troponina I cardíaca é encontrada apenas no coração, sendo expressa exclusivamente pelo miocárdio, e está especialmente associada às miofibrilas, embora pequenas quantidades estejam presentes também no citosol (Dunn et al, 2008).…”

“…Normalmente não são detectáveis na circulação por estarem presentes em pequenas quantidades. No entanto, quando há um dano à célula do miocárdio, a troponina é liberada na circulação e pode ser mensurada por meio de métodos de imunoensaio (Hamacher et al, 2015;Sheyin et al, 2015;Tiruvoipati et al, 2012).…”

Pulmonary Hypertension in the Dog

“…Although elevations in cardiac TnI are signifi cantly and positively correlated with mean PAP and are associated with increased risk of morbidity and mortality in human patients with PH [77], studies on the prognostic value of this biomarker in dogs with PH are still lacking. This biomarker is considered useful in detecting myocardial damage in cardiac and extra-cardiac conditions [78][79][80][81] and may serve as a global measure of adequacy of RV adaptation to increased afterload more than as an index of PH [77].…”