Serum C3 levels in acute glomerulonephritis and postnephritic children.

Popović-Rolović, M

doi:10.1136/adc.48.8.622

Cited by 13 publications

(9 citation statements)

References 20 publications

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“…Since APSGN might result in CKD and ESRD in a significant percentage of adults and children, there have been many attempts to identify poor prognostic features of APSGN. Nephrotic range proteinuria, impaired renal function, persistent oligouria, and severe crescentic glomerulonephritis have ever been linked with unfavorable outcome, while the reduction in C3 concentration did not correlate with the severity of APSGN [27]. The two patients with chronic kidney disease in this study matched this pattern.…”

Section: Discussionsupporting

confidence: 77%

Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis

Lee

et al. 2010

Pediatr Nephrol

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Acute poststreptococcal glomerulonephritis (APSGN) is the most common form of postinfectious nephritis worldwide. The relationship between inflammation and arterial stiffness has been described elsewhere, but there have been no studies that have analyzed the association between arterial compliance and APSGN. The aim of this study is to assess brachial-ankle pulse wave velocity (baPWV) in pediatric patients with APSGN, and the value of baPWV in predicting the outcome. We evaluated 16 children diagnosed with APSGN, 11 children with acute pyelonephritis (APN), and 25 healthy individuals in our hospital. The baPWV of all candidates was measured. In addition, follow-up of the APSGN group was conducted for baPWV, blood pressure and biochemical parameters. Significantly increased baPWV was observed in the APSGN group at initial diagnosis (P<0.001), in comparison with the APN group and healthy controls. Of these, 13 patients received sequential measurement of baPWV. Overwhelmingly, baPWV was rapidly normalized in 11 patients, whereas 2 boys presented with persistently higher baPWV. During the follow-up period of 2-3 years, both had consistency of proteinuria, and consequently, they progressed to either chronic renal insufficiency or end-stage renal disease (ESRD). In conclusion, the results demonstrate that APSGN involves not only the kidney, but also the arteries outside the kidney. Acute arterial stiffness might persist in patients who do not recover, but develop chronic kidney disease (CKD).

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Section: Discussionsupporting

confidence: 77%

Acute reversible changes of brachial-ankle pulse wave velocity in children with acute poststreptococcal glomerulonephritis

Lee

et al. 2010

Pediatr Nephrol

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“…All patients covered by our study were hypocontplementemic in the early phase o f A P S G N . A transient reduction of serum complement activity and/or a de crease in C3 serum concentration was detected in 90% or more patients in other studies [13,14,[18][19][20]. The course of the disease in a small number o f normocomplementemic patients was not different from that in hypocomplementemics [13,21].…”

Section: IImentioning

confidence: 80%

“…The diagnosis o f A P S G N in those patients with an acute onset of the disease and no past or family history o f previous renal disease was established according to the five major criteria: (1) haematuria with red blood cell casts (R B C casts); (2) transient reduction o f serum C3 complement component level and/or haemolytic comple ment [13,14]; (3) elevated A SO T >200 Todd's units, and/or A H T > 500 units ; (4) oedema, and (5) hypertension (BP > P97 for age and sex) [II].…”

Section: Methodsmentioning

confidence: 99%

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Medium- and Long-Term Prognosis of Patients with Acute Poststreptococcal Glomerulonephritis

Popović-Rolović¹,

Kostić²,

Antić-Peco³

et al. 1991

Nephron

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The prognosis of acute poststreptococcal glomerulonephritis (APSGN) is still a matter of considerable debate. In an attempt to elucidate this controversy, the medium-term prognosis was evaluated in 40 patients 5–9 years after the onset of the disease, and the long-term prognosis in 88 patients 10–17 years after the onset of the disease. All were sporadic cases. In the medium-term follow-up study, abnormalities were revealed in 5.0% (2/40) of the patients. Hypertension and proteinuria were the only abnormalities detected. In the long-term follow-up study, abnormalities were revealed in 6.8% (6/88) of the patients. Hypertension was found in 3.4, proteinuria in 2.3, and microhaematuria in 2.3% of the patients. In both studies, all patients had normal creatinine clearance. We conclude that the medium-and long-term outcome of patients with APSGN is excellent.

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“…(16) High titre of Anti-Streptolysin O (ASO) is taken as more than 200 Todd units. (17) Serum C3 was taken as decreased if below 75 mg/dL estimated by immunoturbidimetric assay. Anaemia defined according to age and sex as mild, moderate and severe anaemia.…”

Section: Methodsmentioning

confidence: 99%