Medium- and Long-Term Prognosis of Patients with Acute Poststreptococcal Glomerulonephritis

Popović-Rolović, M; Kostić, Marija; Antić-Peco, A.; Jovanović, O; Popović, D. S.

doi:10.1159/000186469

Cited by 38 publications

(20 citation statements)

References 11 publications

(20 reference statements)

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“…The long-term prognosis in children is also excellent. [5][6][7][8][9] The prognosis of the disease may be not so favorable in patients with additional risk factors such as low birth weight, older age, hypertension, diabetes or preexisting kidney disease. [10][11][12][13] Analysis of the follow-up data in our series revealed that three children fully recovered.…”

Section: Discussionmentioning

confidence: 99%

Poststreptococcal glomerulonephritis in children with congenital anomalies of the kidney and urinary tract

et al. 2015

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Background: The objective of this study was to assess clinical course and outcome of children with congenital anomalies of the kidney and urinary tract (CAKUT) who had an attack of acute poststreptococcal glomerulonephritis (PSGN). Method: Renal status including blood pressure, proteinuria and glomerular filtration rate was retrospectively analyzed in five children with CAKUT and PSGN at the presentation and during the follow up. Results: In the period 2004-2013, 678 patients were diagnosed and recruited in our CAKUT cohort. During this period, 188 patients were hospitalized with the diagnosis of PSGN. A total of five patients had CAKUT and an episode of PSGN (2.6%). Analysis of the follow-up data revealed that three children fully recovered (bilateral vesicoureteral reflux n ¼ 1, ectopic/hypodysplastic kidney n ¼ 1, ureteropelvic junction obstruction n ¼ 1). One child with bilateral hypodysplasia had progressive worsening of the renal function and has been prepared for renal replacement therapy. Another child with single kidney has stable renal function but has significant rising proteinuria, which was not evident on the routine analysis 2 months before the attack of PSGN. Conclusion: Poststreptococcal glomerulonephritis in children is generally benign disease with low mortality in acute stage and excellent medium and long-term prognosis. We analyzed our series of PSGN patients and found that 2.6% had anomaly of the urinary tract. The unfavorable outcome was noted in children with single kidney and bilateral renal impairment.

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Section: Discussionmentioning

confidence: 99%

Poststreptococcal glomerulonephritis in children with congenital anomalies of the kidney and urinary tract

et al. 2015

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“…It has a variety of initial symptoms. Severe headaches are the most frequent complaint of patients [1][2][3][4][5][6][7][8]. These may be Cerebral vasculitis can be caused by an infectious or noninfectious disease.…”

Section: Discussionmentioning

confidence: 99%

“…Examples of the noninfec tious causes are the following: systemic necrotizing vasculitides; vasculitis associated with collagen vascular dis ease; neurosarcoid vasculitis, and drug-abuse vasculitis. The incidence of vasculitis following APSGN is increas ing [2,4,6,8], Vasculitis involving the skin is becoming more well-documented [ 1,2,4. 6].…”

Section: Discussionmentioning

confidence: 99%

Cerebral Vasculitis Associated with Acute Post-Streptococcal Glomerulonephritis

Rovang

Zawada²,

Santella³

et al. 1997

Am J Nephrol

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The following is a case study involving a 13-year-old girl who presented initial symptoms of an upper respiratory infection. One week later she experienced a short seizure and hours later a grand mal seizure. MRI examination of the brain demonstrated multiple changing abnormal foci of increased density in white and gray matter suggestive of a vasculitic inflammatory pattern. As a result of proteinuria and red cell casts on urinalysis, a renal biopsy was performed resulting in a diagnosis of acute post-streptococcal glomerulonephritis (APSGN). We concluded on the basis of the MRI that vasculitis was secondary to APSGN. The following paper is a description of our findings in this case and a review of the literature supporting this new interpretation of CNS disease due to APSGN.

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“…Patients with MCD, PSGN and glomerular hematuria were not included in the analysis of loss of renal function since progression to chronic renal failure is rare in these patients [9, 10, 11]. Our patients with PSGN were in different stages of disease; 10 were in the acute phase (first 2 months after the onset of symptomatology), 12 in the recovery phase (usually more than 2 months after the onset of symptoms but still with urinary abnormalities) and 14 could be considered cured (absence of urinary abnormalities or only slight or intermittent hematuria).…”

Section: Methodsmentioning

confidence: 99%

Urinary Retinol-Binding Protein as a Prognostic Marker in Glomerulopathies

Kirsztajn¹,

Nishida²,

Silva³

et al. 2002

Nephron

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Tubulointerstitial involvement seems to have a decisive influence on the progression of glomerular diseases. We have prospectively evaluated the levels of urinary retinol-binding protein (urRBP), a marker of proximal tubular dysfunction, in patients with different glomerulopathies (GPs) and correlated these levels with disease progression. By studying 238 patients with GPs, we found that urRBP tend to be lower in minimal change disease, glomerular hematuria and poststreptococcal glomerulonephritis as compared to focal segmental glomerulosclerosis, membranous nephropathy and membranoproliferative glomerulonephritis. By following 149 patients for up to 10 years, we have concluded that high levels of urRBP can identify patients who will progress with loss of renal function (defined as doubling of serum creatinine level) and that a urRBP level >1 mg/l was an efficient and independent indicator of poor prognosis as shown by multivariate analysis. This prediction was possible at a time when serum creatinine and creatinine clearance were still in the normal range. Our data suggest that this laboratory test adds important clinical information to the follow-up of GPs.

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Medium- and Long-Term Prognosis of Patients with Acute Poststreptococcal Glomerulonephritis

Cited by 38 publications

References 11 publications

Poststreptococcal glomerulonephritis in children with congenital anomalies of the kidney and urinary tract

Poststreptococcal glomerulonephritis in children with congenital anomalies of the kidney and urinary tract

Cerebral Vasculitis Associated with Acute Post-Streptococcal Glomerulonephritis

Urinary Retinol-Binding Protein as a Prognostic Marker in Glomerulopathies

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