Urinary Retinol-Binding Protein as a Prognostic Marker in Glomerulopathies

Kirsztajn, Gianna Mastroianni; Nishida, Sônia K.; Silva, Marcelo de Souza; Ajzen, H; Moura, Luiz Antônio Ribeiro de; Pereira, Aparecido B.

doi:10.1159/000054730

Cited by 37 publications

(10 citation statements)

References 9 publications

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“…Retinol-binding protein (RBP) is a low molecular weight protein (21 kDa) that transports retinol (vitamin A alcohol) from the liver to peripheral tissues. It passes freely through glomerular membranes and is reabsorbed by renal proximal tubules cells where it is catabolized, so an increase in the urinary excretion of RBP indicates proximal tubule injury and/or impaired proximal tubular function [ 57 , 58 ]. High levels of urine RBP suggest the presence of tubular injury in HIV-infected patients [ 31 ].…”

Section: Retinol Binding Proteinmentioning

confidence: 99%

Urinary Markers of Tubular Injury in HIV-Infected Patients

Fiseha

Gebreweld

2016

Biochemistry Research International

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Renal disease is a common complication of HIV-infected patients, associated with increased risk of cardiovascular events, progression to AIDS, AIDS-defining illness, and mortality. Early and accurate identification of renal disease is therefore crucial to improve patient outcomes. The use of serum creatinine, along with proteinuria, to detect renal involvement is essentially to screen for markers of glomerular disease and may not be effective in detecting earlier stages of renal injury. Therefore, more sensitive and specific markers are needed in order to early identify HIV-infected patients at risk of renal disease. This review article summarizes some new and important urinary markers of tubular injury in HIV-infected patients and their clinical usefulness in the renal safety follow-up of TDF-treated patients.

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Section: Retinol Binding Proteinmentioning

confidence: 99%

Urinary Markers of Tubular Injury in HIV-Infected Patients

Fiseha

Gebreweld

2016

Biochemistry Research International

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“…Mastroianni Kirsztajn et al [18, 19] concluded that this biomarker reflects the occurrence of transitory or permanent tubulointerstitial dysfunction, and is a helpful tool for the follow-up of patients with GNs, making it possible to watch their progression to renal failure as well as their responsiveness to treatment, particularly in cases of idiopathic nephrotic syndrome.…”

Section: Discussionmentioning

confidence: 99%

“…As this parameter has been extensively studied at our institute [18,19,20], where an adequate method for determination of RBP has been developed [21,22,23], it will be analyzed here.…”

Section: Introductionmentioning

confidence: 99%

Relative Contribution of Morphometric and Functional Indicators of Tubulointerstitial Lesion to Glomerular Diseases Prognosis

Deus¹,

Teixeira²,

Kirsztajn³

2008

Nephron Clin Pract

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Background: Early diagnosis of proximal tubular lesions can be achieved by detecting abnormal levels of low molecular weight proteins in urine. Material and Methods: 100 cases of glomerulopathies were retrospectively studied to establish the profile of urinary levels of retinol-binding protein (urRBP) and their correlation with histological markers of tubulointerstitial lesions in renal biopsies. The histological study included staining with picrosirius red. Results: Nonproliferative glomerulopathies, male sex, white race and young adults were predominant. The chance of abnormal urRBP occurring was higher among patients with a predominant proliferative component, baseline serum creatinine >1.2 mg/dl (p = 0.008), creatinine clearance <70 ml/min (p = 0.006), and severe interstitial fibrosis (p = 0.042). In multivariate analysis, only serum creatinine and creatinine clearance were independently associated to urRBP, and only urRBP was a time-independent prognostic factor for survival without renal failure (risk of renal failure: 9×). Conclusion: Our study suggests that urRBP determination is prognostically relevant in the progression of glomerulopathies; on the other hand, the evaluated morphometric markers correlated poorly with the clinical outcome of these patients. Consequently, urRBP determination, as a functional marker of tubulointerstitial damage, was more appropriate for determining the prognosis of glomerular diseases than the morphometric analysis of renal biopsies.

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“…Even a slight impairment of the renal tubule can lead to increased urinary excretion of RBP. 40,41 Kuźniar et al 42 reported that an increase in urinary RBP excretion may be due to interstitial damage and not a decrease in the number of active nephrons. Such a conclusion was based on the lack of a correlation between RBP excretion and serum creatinine concentrations.…”

Section: Methodsmentioning

confidence: 99%

A panel of urinary biochemical markers for the non-invasive detection of kidney dysfunction in HIV-patients

Szymańska¹,

Marchewka²,

Knysz³

et al. 2019

Polish Archives of Internal Medicine

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INTRODUCTION The use of antiretroviral therapy in HIV-infected patients can lead to disturbances in kidney function. Renal dysfunction can also be caused by the direct effects of HIV on the kidneys. The assessment of renal function is needed to monitor these patients for the development of chronic kidney disease. OBJECTIVES The aim of this study was to identify urinary biochemical parameters for the assessment of kidney dysfunction in HIV-infected patients. PATIENTS AND METHODS The study included 86 patients with HIV and 34 healthy controls. Spectrophotometry was used to measure the activity of the following enzymes: N-acetyl-β-D-glucosaminidase (NAG), NAG isoenzyme B (NAG-B), galactosidase, β-glucuronidase, alanyl aminopeptidase, and γ-glutamyltransferase. An enzyme-linked immunosorbent assay was used to assess the urinary concentrations of low-molecular-weight proteins: kidney injury molecule 1 (KIM-1), neutrophil gelatinase-associated lipocalin, α-glutathione S-transferase, π-glutathione S-transferase, neopterin, β 2-microglobulin (β 2 M), and retinol-binding protein (RBP). RESULTS The urinary levels of all parameters except alanyl aminopeptidase were significantly higher in HIV-infected patients than in the control group. The statistical analysis revealed the following 4 parameters to have the best diagnostic value in: β 2 M, NAG, KIM-1, and RBP. CONCLUSIONS Our results indicate that among selected enzymes and low-molecular proteins, β 2 M, NAG, KIM-1, and RBP are the best in assessing renal dysfunction in patients with HIV.

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Urinary Retinol-Binding Protein as a Prognostic Marker in Glomerulopathies

Cited by 37 publications

References 9 publications

Urinary Markers of Tubular Injury in HIV-Infected Patients

Urinary Markers of Tubular Injury in HIV-Infected Patients

Relative Contribution of Morphometric and Functional Indicators of Tubulointerstitial Lesion to Glomerular Diseases Prognosis

A panel of urinary biochemical markers for the non-invasive detection of kidney dysfunction in HIV-patients

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