Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity but not to Genetic Polymorphisms within BDNF Encoding Gene in Patients with Type 2 Diabetes

Abstract

BackgroundThe aim of this study was to investigate the association between serum concentrations of the brain-derived neurotrophic factor (BDNF), platelet reactivity and inflammatory markers, as well as its association with BDNF encoding gene variants in type 2 diabetic patients (T2DM) during acetylsalicylic acid (ASA) therapy.Material/MethodsThis retrospective, open-label study enrolled 91 patients. Serum BDNF, genotype variants, hematological, biochemical, and inflammatory markers were measured. Blood samples were taken in the morning 2–3 h after the last ASA dose. The BDNF genotypes for selected variants were analyzed by use of the iPLEX Sequenom assay.ResultsIn multivariate linear regression analysis, CADP-CT >74 sec (p<0.001) and sP-selectin concentration (p=0.03) were predictive of high serum BDNF. In multivariate logistic regression analysis, CADP-CT >74 sec (p=0.02) and IL-6 concentration (p=0.03) were risk factors for serum BDNF above the median. Non-significant differences were observed between intronic SNP rs925946, missense SNP rs6265, and intronic SNP rs4923463 allelic groups and BDNF concentrations in the investigated cohort.ConclusionsChronic inflammatory condition and enhanced immune system are associated with the production of BDNF, which may be why the serum BDNF level in T2DM patients with high platelet reactivity was higher compared to subjects with normal platelet reactivity in this study.

Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity and Metformin Treatment in Adult Patients With Type 2 Diabetes Mellitus

“…Along with glucose metabolism, studies have also shown that BDNF is associated with lipid metabolism. In our study, we found that serum BDNF levels were significantly positively correlated with total cholesterol, triglyceride and LDL levels, which is a confirmation of other recent studies (5,51,53,54). These results may suggest that BDNF plays a role in the treatment of diabetes and dyslipidemia.…”

Clinical utility of brain-derived neurotrophic factor as a biomarker with left ventricular echocardiographic indices for potential diagnosis of coronary artery disease

“…Finally, we generate SVM models to determine the influence BDNF in improving the classification of CAD from control by including and excluding the BDNF attribute while training and testing the models. Our present study showed decreased serum BDNF in CAD which is in agreement with Eyileten et al, 2016, confirming the decreased serum BDNF that correlates with VCAM1 and soluble P-selectin in CAD 21 . Similarly, Aleksandra Sustar et al, 2019 reports lower BDNF in the CAD associated with an increased risk of cardiovascular events and mortality 22 .…”

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

“…Multiple sclerosis (MS) is a progressive, chronic, autoimmune inflammatory and degenerative process that damages CSN. MS is characteristic for patients with the presence of plaques and lesions in the brain and spinal cord, primarily the white matter of the brain [ 3 , 7 , 85 , 86 ]. The mechanism of MS development remains poorly understood.…”

“…BDNF has previously been discovered in endothelial cells, muscle tissues, liver, and adipose tissues. Later on, it was also found in immune cells, such as lymphocytes and monocytes [ 1 , 3 ]. It was stated that the three areas where BDNF is most active are the hippocampus, cortex, and basal forebrain [ 4 , 5 ].…”