Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity and Metformin Treatment in Adult Patients With Type 2 Diabetes Mellitus

Eyileten, Ceren; Mirowska‐Guzel, Dagmara; Milanowski, Łukasz; Zaremba, M; Rosiak, Marek; Cudna, Agnieszka; Kapłon‐Cieślicka, Agnieszka; Opolski, Grzegorz; Filipiak‬, Krzysztof J.; Małek, Łukasz A.; Postuła, Marek

doi:10.1016/j.jcjd.2018.01.014

Cited by 20 publications

(15 citation statements)

References 53 publications

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“…Along with the nerve growth factor and neurotrophins (NT), brain-derived neurotrophic factor (BDNF) is a member of the NT family that has a crucial role in the development and maintenance of the nervous system. It regulates neurotransmission, neuronal regeneration and morphology, and the functional synaptic plasticity in neurons both in the peripheral nervous system and central nervous system (CNS) by binding tropomyosin receptor kinase B (TrkB) [1,2]. BDNF has previously been discovered in endothelial cells, muscle tissues, liver, and adipose tissues.…”

Section: Introductionmentioning

confidence: 99%

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

et al. 2020

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Brain-derived neurotrophic factor (BDNF) is a member of the neurotrophin family of growth factors that plays a crucial role in the development of the nervous system while supporting the survival of existing neurons and instigating neurogenesis. Altered levels of BDNF, both in the circulation and in the central nervous system (CNS), have been reported to be involved in the pathogenesis of neurodegenerative diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), Huntington’s disease (HD), multiple sclerosis (MS), and ischemic stroke. MicroRNAs (miRNAs) are a class of non-coding RNAs found in body fluids such as peripheral blood and cerebrospinal fluid. Several different miRNAs, and their target genes, are recognized to be involved in the pathophysiology of neurodegenerative and neurovascular diseases. Thus, they present as promising biomarkers and a novel treatment approach for CNS disorders. Currently, limited studies provide viable evidence of miRNA-mediated post-transcriptional regulation of BDNF. The aim of this review is to provide a comprehensive assessment of the current knowledge regarding the potential diagnostic and prognostic values of miRNAs affecting BDNF expression and its role as a CNS disorders and neurovascular disease biomarker. Moreover, a novel therapeutic approach in neurodegenerative diseases and ischemic stroke targeting miRNAs associated with BDNF will be discussed.

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Section: Introductionmentioning

confidence: 99%

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

et al. 2020

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“…In their research, they proved that adiponectin levels were significantly associated with serum BDNF levels. In their multivariate backward stepwise analysis, they showed that CADP-CT (collagen-adenosine diphosphate closure time) >141 s; adiponectin concentration >4.22 µg/mL; total cholesterol and low-density lipoprotein levels were independently associated with serum BDNF levels above the median [35].…”

Section: Bdnf and Adipocytokinesmentioning

confidence: 99%

Brain-Derived Neurotrophic Factor and Diabetes

Różańska

Uruska

Zozulińska−Ziółkiewicz

2020

IJMS

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Diabetes and its chronic complications still represent a great clinical problem, despite improvements made in the diagnosis and treatment of the disease. People with diabetes have a much higher risk of impaired brain function and psychiatric disorders. Neurotrophins are factors that protect neuronal tissue and improve the function of the central nervous system, and among them is brain-derived neurotrophic factor (BDNF). The level and function of BDNF in diabetes seems to be disturbed by and connected with the presence of insulin resistance. On the other hand, there is evidence for the highly beneficial impact of physical activity on brain function and BDNF level. However, it is not clear if this protective phenomenon works in the presence of diabetes. In this review, we summarize the current available research on this topic and find that the results of published studies are ambiguous.

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“…BDNF acts through several different pathways including the MAPK pathway and PI3K-Akt cascade, which induce cell survival and synaptic plasticity. Apart from the nervous system, many studies showed the importance of BDNF during systemic or peripheral inflammatory conditions, such as acute coronary syndrome and T2DM [ 67 , 68 , 111 ]. It is known to play an important role in glucose and energy homeostasis.…”

Section: C-reactive Proteinmentioning

confidence: 99%

Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes

Siwik

Gajewska

Jaguszewski

et al. 2020

JCM

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Diabetes mellitus (DM) is a common disease worldwide. There is a strong association between DM and neurovascular and neurodegenerative disorders. The first group mainly consists of diabetic retinopathy, diabetic neuropathy and stroke, whereas, the second group includes Alzheimer’s disease, Parkinson’s disease, mild cognitive impairment and dementia. The aforementioned diseases have a common pathophysiological background including insulin resistance, oxidative stress, atherosclerosis and vascular injury. The increasing prevalence of neurovascular and neurodegenerative disorders among diabetic patients has resulted in an urgent need to develop biomarkers for their prediction and/or early detection. The aim of this review is to present the potential application of the most promising biomarkers of diabetes-related neurodegenerative and neurovascular disorders, including amylin, β-amyloid, C-reactive protein (CRP), dopamine, gamma-glutamyl transferase (GGT), glycogen synthase kinase 3β, homocysteine, microRNAs (mi-RNAs), paraoxonase 1, phosphoinositide 3-kinases, tau protein and various growth factors. The most clinically promising biomarkers of neurovascular and neurodegenerative complications in DM are hsCRP, GGT, homocysteine and miRNAs. However, all biomarkers discussed in this review could become a part of the potential multi-biomarker screening panel for diabetic patients at risk of neurovascular and neurodegenerative complications.

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Serum Brain-Derived Neurotrophic Factor is Related to Platelet Reactivity and Metformin Treatment in Adult Patients With Type 2 Diabetes Mellitus

Cited by 20 publications

References 53 publications

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

The Relation of the Brain-Derived Neurotrophic Factor with MicroRNAs in Neurodegenerative Diseases and Ischemic Stroke

Brain-Derived Neurotrophic Factor and Diabetes

Early Biomarkers of Neurodegenerative and Neurovascular Disorders in Diabetes

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