Clinical utility of brain-derived neurotrophic factor as a biomarker with left ventricular echocardiographic indices for potential diagnosis of coronary artery disease

Abstract

Brain-derived neurotrophic factor (BDNF) plays a central pivotal role in the development of the cardiovascular system. Recent evidence suggests that BDNF has adverse subclinical cardiac remodeling in participants with cardiovascular disease risk factors. Relating serum BDNF levels with two-dimensional echocardiographic indices will provide insights into the BDNF mediated pathophysiology in coronary artery disease (CAD) that may shed light upon potential diagnostic biomarkers. For the study, 221 participants were recruited and classified based on coronary angiogram examination as control (n = 105) and CAD (n = 116). All participants underwent routine blood investigation, two-dimensional echocardiography, and serum BDNF estimation. As a result, total cholesterol, triglyceride, low-density lipid, high-density lipid, HbA1c (glycosylated hemoglobin), serum creatinine, eosinophils, lymphocyte, monocytes, neutrophils, and platelets were significantly elevated in CAD individuals compared to controls. Notably, the serum BDNF was significantly lower in individuals with CAD (30.69 ± 5.45 ng/ml) than controls (46.58 ± 7.95 ng/ml). Multivariate regression analysis showed neutrophils, total cholesterol, left ventricular mass index, mitral inflow E/A ratio, and pulmonary vein AR duration were associated with low BDNF in CAD. Four independent support vector machine (SVM) models performed to ensure the BDNF level in the classification of CAD from healthy controls. Particularly, the model with serum BDNF concentration and blood parameters of CAD achieved significant improvement from 90.95 to 98.19% in detecting CAD from healthy controls. Overall, our analysis provides a significant molecular linkage between the serum BDNF level and cardiovascular function. Our results contribute to the emerging evidence of BDNF as a potential diagnostic value in CAD that might lead to clinical application.

Brain-Derived Neurotrophic Factor And Coronary Artery Disease

“…In the article by K.G. Monisha et al, it was also shown that the level of BDNF was significantly lower in individuals with CAD (30.69 ± 5.45 ng/mL) than in the control group (46.58 ± 7.95 ng/mL) [23]. It was confirmed that the expression of BDNF receptor was significantly reduced in patients with coronary atherosclerosis [12].…”

“…This is due to their participation in the control of the functioning of the nervous, immune, endocrine, and vascular systems, as well as in initiation and resolution of inflammation. Currently, there are data on the role of NTF in the pathogenesis of metabolic [14] and neurodegenerative diseases [15][16][17][18][19], along with cardiovascular pathology [20][21][22][23][24][25]. In recent years, the attention of scientists has been attracted by the brainderived neurotrophic factor (BDNF), which is a member of one of the NTF families.…”

“…In the last decade, the attention of scientists was directed to studying the role of BDNF in the pathogenesis of atherosclerosis as an initiating factor of CVD [20][21][22][23][24][25]. This relationship will be discussed below.…”

“…Clinical studies established the role of BDNF as a risk factor for stroke and a marker of prognosis, mortality, and functional outcome among survivors of ischemic stroke [13,18]. It is obvious that there is evidence both supporting the role of BDNF in the development of CVD and data clarifying the degree of linearity of this relationship [23,25,77]. Immune system Participation in inflammation [47] Musculoskeletal system Bone regeneration Neuromuscular transmission improvement [64,65] Bronchopulmonary system Regeneration of alveolar epithelial cells [66] Reproductive system Gonad development Regulation of ovarian and uterine functions Development of the embryo and placenta [67] Cardiovascular system…”

miR-182-5p combined with brain-derived neurotrophic factor assists the diagnosis of chronic heart failure and predicts a poor prognosis

“…Brain-derived neurotrophic factor (BDNF) regulates neurotrophin and neuronal survival in the brain, exerting important functions in the survival, growth, differentiation, and repair of cells, synaptic plasticity, and adult/embryonic neurogenesis in the neurons of the central nervous system by stimulating tropomyosin receptor kinase B [ 19 , 20 ]. BDNF is a pivotal player in the progression of the cardiovascular system and a low circulating BDNF level is linked with higher cardiovascular risks [ 21 , 22 ]. Moreover, the level of serum BDNF is reduced in HF patients [ 23 ], indicating the correlation between BDNF and CHF.…”