Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET

Kim, Jee Hyun; Shin, Mi Sun; Yi, Gwang; Jee, Byung Chul; Lee, Jung Ryeol; Suh, Chang Suk; Kim, Seok Hyun

doi:10.5653/cerm.2012.39.1.28

Cited by 15 publications

(20 citation statements)

References 19 publications

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“…The subjects showed a mean β -hCG level of 157.3±79.5 mIU/mL and a mean progesterone level of 29.9±17.4 ng/mL 14 days after oocyte retrieval, which is similar with those of previous reports [16–18]. In the comparison of the β -hCG and progesterone levels, significantly higher levels were shown in the ongoing pregnancy maintenance group than in the miscarriage group, which is also consistent with those of previous studies [16–18]. A previous study revealed that patients with repeated miscarriages showed significantly decreased hCG and progesterone secretion compared to healthy controls [19].…”

Section: Discussionsupporting

confidence: 90%

Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization

et al. 2017

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ObjectiveTo evaluate the predictive value of the progesterone level at the beta-human chorionic gonadotropin (β-hCG) check day for ongoing pregnancy maintenance in in vitro fertilization (IVF) cycles in women with previous unexplained repeated miscarriages.Materials and methodsOne hundred and forty-eight women, with visible gestational sac after IVF, were recruited in this observational study. All subjects had unexplained recurrent miscarriages in more than two previous IVF cycles. The progesterone level at the β-hCG check day (i.e. 14 days after oocyte retrieval) was assessed. The area under the curve (AUC) of the progesterone level was evaluated to predict the ongoing pregnancy or miscarriage outcomes.ResultsThe overall ongoing pregnancy rate was 60.8% (90/148). The cut-off value with β-hCG levels higher than 126.5 mIU/mL and with progesterone levels higher than 25.2 ng/mL could be the predictive factors for ongoing pregnancy maintenance (AUC = 0.788 and 0.826; sensitivity = 0.788 and 0.723; specificity = 0.689 and 0.833; P < 0.0001 and P < 0.0001, respectively). The miscarriage rates were 19.5% (15/77) in the women with β-hCG > 126.5 mIU/mL and 13.0% (10/77) in those with > 25.2 ng/mL. In the comparison of the ROC curves between both values, a similar significance was found. The subjects with β-hCG > 126.5 mIU/mL and progesterone > 25.2 ng/mL showed higher ongoing pregnancy rates [98.0% (49/50) vs. 41.8% (41/98)] than those with β-hCG ≤ 126.5 mIU/mL or progesterone ≤ 25.2 ng/mL.ConclusionsThe progesterone level at 14 days after oocyte retrieval can be a good predictive marker for ongoing pregnancy maintenance in women with repeated IVF failure with miscarriage, together with the β-hCG level. The combined cut-off value of progesterone > 25.2 ng/mL and β-hCG > 126.5 mIU/mL may suggest a good prognosis.

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Section: Discussionsupporting

confidence: 90%

Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization

et al. 2017

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“…The median value was higher in successfully delivered (572 IU/L) and ongoing (977 IU/L) pregnancies compared to nonviable pregnancies (174 IU/L) which was similar to the results reported earlier. [1345151617182125262728] The levels of day 14 βhCG was found to be significantly higher in women with higher order pregnancies compared to those with singletons ( P < 0.01), which is similar to studies reported in literature. [12478914161929] The present study is unique as it defines the cutoff value of βhCG as early as day 14 post ET.…”

Section: Discussionsupporting

confidence: 87%

“…It has been suggested that βhCG has more predictive value than other biochemical markers for predicting and assessing pregnancy outcome. [1511] Our data also shows that there were significant differences in the value of βhCG levels studied 14 days post ET in women with viable versus nonviable pregnancies. The median value was higher in successfully delivered (572 IU/L) and ongoing (977 IU/L) pregnancies compared to nonviable pregnancies (174 IU/L) which was similar to the results reported earlier.…”

Section: Discussionsupporting

confidence: 56%

Role of early serum beta human chorionic gonadotropin measurement in predicting multiple pregnancy and pregnancy wastage in an in vitro ET fertilization cycle

Singh¹,

Begum²,

Malhotra³

et al. 2013

J Hum Reprod Sci

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OBJECTIVE:This study was performed to assess the prognostic value of serum beta human chorionic gonadotropin (βhCG), measured on day 14 post embryo transfer (ET) for predicting multiple gestation and pregnancy wastage in women undergoing in vitro fertilization ET (IVF-ET).MATERIALS AND METHODS:This retrospective study was performed between May 2009 and November 2012. Out of the 181 women who conceived, 168 were included and the remaining 13 were excluded as their pregnancy was biochemical. Serum βhCG was measured using a chemiluminescent enzyme immunometric assay. The predictive values of serum βhCG for establishing multiple pregnancy and pregnancy wastages were calculated by receiver operating characteristic (ROC) curve analysis. Median values of serum βhCG and outcome of all pregnancies were compared.RESULTS:Out of the 168 patients who conceived after IVF treatment, 114 (68%) were viable pregnancies (delivered/ongoing). Among the viable pregnancies, 97 (85%) had a successful pregnancy outcome and the remaining 17 patients are ongoing pregnancies. Median values of βhCG (625 IU/L) among viable pregnancies was significantly (P < 0.05) higher than that of nonviable pregnancies (174 IU/L). The median values of βhCG for singleton (502 IU/L), twins (1093 IU/L), and triplets (2160 IU/L) was statistically significant (P < 0.05). Using ROC curve it was predicted that for a value of βhCG at 375 IU/L, the sensitivity of viable pregnancy was 65% and specificity of viable pregnancy was also 65%, with positive and negative predictive values of 65 and 68%, respectively. Similarly for multiple pregnancy and pregnancy wastage the predictive values of βhCG were 808 and 375 IU/L, respectively; while the sensitivity and specificity is more than 65% each.CONCLUSION:βhCG cutoff values determined on day 14 post ET by ROC curve analysis are useful in discriminating between multiple pregnancy and pregnancy losses. The cutoff value might aid in the prognosis, clinical management, and counseling of the IVF patients.

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“…The classifications of pregnancy outcomes were the same as previously described [14,15]. Clinical pregnancy was confirmed by the presence of a gestational sac observed on ultrasound scans, and clinical abortion was defined by pregnancy failure after the gestational sac confirmed.…”

Section: Definitions Of the Outcome Measuresmentioning

confidence: 99%

Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

Kim¹,

Kim²,

Jee³

et al. 2014

European Journal of Obstetrics & Gynecology and Reproductiv

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Serum biomarkers for predicting pregnancy outcome in women undergoing IVF: human chorionic gonadotropin, progesterone, and inhibin A level at 11 days post-ET

Cited by 15 publications

References 19 publications

Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization

Predictive value of serum progesterone level on β-hCG check day in women with previous repeated miscarriages after in vitro fertilization

Role of early serum beta human chorionic gonadotropin measurement in predicting multiple pregnancy and pregnancy wastage in an in vitro ET fertilization cycle

Can intracytoplasmic sperm injection prevent total fertilization failure and enhance embryo quality in patients with non-male factor infertility?

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