Serum apolipoprotein E concentration and polymorphism influence serum lipid levels in Chinese Shandong Han population

Abstract

Apolipoprotein E (ApoE), which has been shown to influence serum lipid parameters, can bind to multiple types of lipids and plays an important role in the metabolism and homeostasis of lipids and lipoproteins. A previous study showed that ApoE concentration significantly affects serum lipid levels independently of ApoE polymorphism. The serum lipid levels were also closely correlated with dietary habits, and Shandong cuisine is famous for its high salt and oil contents, which widely differ among the different areas in China. Therefore, studying the effect of ApoE polymorphism on ApoE concentration and serum lipid levels in Shandong province is very important.A total of 815 subjects including 285 men and 530 women were randomly selected and studied from Jinan, Shandong province. In order to evaluate the association of ApoE polymorphism and serum level on lipid profiles, the ApoE genotypes, as well as levels of fasting serum ApoE and other lipid parameters, were detected in all subjects.The frequency of the ApoE E3 allele was highest (83.1%), while those of E2 and E4 were 9.4% and 7.5%, respectively, which are similar to those in other Asian populations. ApoE2 allele carriers showed significantly increased ApoE levels but lower levels of serum total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and Apolipoprotein B (ApoB).We found that ApoE level is influenced by ApoE polymorphism in a gene-dependent manner. The ApoE polymorphism showed different influences on serum lipid parameters with increasing age and body mass index (BMI) in our Shandong Han population.

The effect of APOE, CETP, and PCSK9 polymorphisms on simvastatin response in Thai hypercholesterolemic patients

“…The allele frequencies of the APOE polymorphisms (E2 7.11%, E3 79.56%, E4 13.33%) in this study were similar to previous reports among the Thai population (E2 7.18%‐10.42%, E3 77.04%‐77.51%, E4 12.54%‐15.43%) . APOE4 allele in our study was higher than Japanese (10.5%), Han Chinese (7.5%), Taiwanese (7.5%), and Korean (9%) populations but lower than the Malaysian population (20.20%) . These inconsistent results may be due to the specific populations.…”

Association of Apolipoprotein E Polymorphisms with White Matter Lesions and Brain Atrophy

“…In the Chinese population, the predominant genotype is E3/ E3 in the Chinese population, whereas the most common allele is E3, followed by E2/E3, E3/E4, E2/E4, E4/E4, and E2/E2. [23][24][25] Our research also confirmed that E3/E3 and E3 were dominant. However, in this research, the E3/E4 genotype follows the E3/E3 genotype in WML group and brain atrophy group, respectively, but the E2/E2 genotype follows the E2/E3 genotype in the co-occurrence of WML and brain atrophy disease group.…”

Lipid profile, plasma apolipoproteins, and pre-eclampsia risk in the GenPE case-control study

“…For example, the ApoE gene, APOE, is located on chromosome 19, and has three common alleles that encode three isoforms: ApoE2, ApoE3, and ApoE4. The ApoE2 and ApoE4 isoforms have been reliably associated with high triglyceride and VLDL levels [27,36]. Therefore, it has been postulated that APOE gene polymorphisms are associated with an increased risk of both cardiovascular disease and pre-eclampsia.…”