Serum and vitreous humor antibody titers in and isolation of Leptospira interrogans from horses with recurrent uveitis

Wollanke, B; Rohrbach, Barton W; Gerhards, H

doi:10.2460/javma.2001.219.795

Cited by 93 publications

(102 citation statements)

References 16 publications

(10 reference statements)

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“…1999); (Faber et al 2000); (Donahue and Williams. 2000) Grippotyphosa, Icterohaemorrhagiae Europe (Donahue et al 1995); (Dwyer et al 1995); (Wollanke et al 2001) Bratislava, Icterohaemorrhagiae, Sejroe Sweden (Baverud et al 2009) Bratislava Mongolia (Odontsetseg et al 2005) Icterohaemorrhagiae, Copenhageni, Bratislava Brazil (Hashimoto et al 2007); (Braga et al 2011); (Coiro et al 2012); (Hamond et al 2012); (Pinna et al 2012); (Hamond et al 2013); (Pinna et al 2014) Icterohaemorrhagiae, Bratislava, Pomona Italy (Ebani et al 2012) Sejroe, Bratislava Korea (Jung et al 2010) Copenhageni, Bratislava Netherlands (Houwers et al 2011) Bratislava, Pomona Icterohaemorrhagiae Croatia Grippotyphosa, Sejroe Nothern Poland (Arent and KedzierskaMieszkowska. 2013) Copenhageni South-eastern Australia (Dickeson and Love.…”

Section: Common Serovars Affecting Horses and Their Geographical Locamentioning

confidence: 99%

“…It is thought to occur after the decline of the febrile phase and latent phases that can in some cases lasts several months or as long as 1-2 years after the clinical diagnosis (Bryans. 1955, Wollanke et al 2001. It is recurrent, may be uni-or bilateral and characterized clinically by miosis, congestion of the sclera, photophobia, severe lacrimation and sometimes blindness (Davidson et al 1987).…”

Section: Clinical Signs Of Leptospirosismentioning

confidence: 99%

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A study of leptospirosis in South African horses and associated risk factors

Simbizi

Saulez²,

Potts

et al. 2016

Preventive Veterinary Medicine

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between potential risk factors and both seropositive horses to the predominant serovar Bratislava and to Leptospira spp were statistically evaluated using univariable analysis and multivariable logistic regression models.Adult horses admitted to each equine hospital and horses seen on ambulatory service for various purposes were included in the study. Severely-ill, chronically infected, and horses with underlying immunosuppressive conditions were excluded from sampling, to control for potential bias.A total of 663 horse sera were collected and tested against a panel of 24 leptospiral serovars using the microscopic agglutination test. The most predominant serovars in Gauteng were The apparent prevalence to one or more serovars of Leptospira spp at a serum dilution of 1:100 in Gauteng, KwaZulu-Natal and Western Cape Provinces was 49%; 37% and 32% respectively. The true prevalence was calculated for each province taking into account the clustering effect during the sampling and was found to be between 24-74% in Gauteng; 26-39% in the Western Cape and 20-54% in KwaZulu-Natal.iv Nooitgedacht (South African horse breed) horses were found to be at greater risk of being seropositive to both serovar Bratislava (OR=5.08) and Leptospira spp (OR=6.3). Similarly, horses residing on properties with forestry in the vicinity were found to be at greater risk of being seropositive to both serovar Bratislava (OR=9.3) and Leptospira spp (OR=5.2). This study has shown that a high proportion of horses in South Africa are exposed to a wide range of serovars, inferring a complex epidemiology. It also describes for the first time new serovars of Leptospira in South African horses that have not previously been reported.v

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Section: Common Serovars Affecting Horses and Their Geographical Locamentioning

confidence: 99%

Section: Clinical Signs Of Leptospirosismentioning

confidence: 99%

A study of leptospirosis in South African horses and associated risk factors

Simbizi

Saulez²,

Potts

et al. 2016

Preventive Veterinary Medicine

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“…So blieben postoperativ 42 von 43 (97,7 %) Augen über 67 Monate (Winterberg und Gerhards 1997), 33 von 38 (86,8 %) Augen nach Single-Port-PPV über einen Zeitraum von 5 Jahren (Frühauf et al 1998) Die Ätiopathogenese der ERU ist noch nicht abschließend geklärt. So werden in der aktuellen, ophthalmologischen Forschung Zusammenhänge zwischen dem direkten und indirekten Leptospirennachweis und der Erkrankung (Rimpau und Heusser 1947, Williams et al 1971, Halliwell et al 1985, Dwyer et al 1995, Brem et al 1999, Faber et al 2000, Wollanke et al 2001, Hartskeerl et al 2004, Niedermaier et al 2006, Brandes et al 2007, Gilger et al 2008, Loibl 2009), Autoimmunreaktionen als Ursache der ERU (Tizard 1992, Deeg et al 2008, Regan et al 2012, Zipplies et al 2012) und genetische Ursachen (Alexander und Keller 1990, Dwyer et al 1995, Kulbrock et al 2013, Fritz et al 2014 …”

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Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis (ERU)

Keiter¹,

Töth²,

Dikker³

et al. 2017

PHK

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Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis (ERU)In the ongoing discussion regarding aetiopathogenesis and therapeutic approach of equine recurrent uveitis (ERU) it was the aim of the present study to elucidate the relationship of leptospiral antibody detection in vitreous humor and success of pars plana vitrectomy (PPV) in horses with ERU. In a retrospective study of 118 ERU patients of different age, gender and breed undiluted vitreous humor, aseptically taken at the beginning of PPV, was examined by culture. Furthermore vitreous humor and serum were tested for specific antibodies against different serovars of Leptospira interrogans by microscopic agglutination test (MAT). Horses were treated via single port pars plana vitrectomy. The presence or absence of inflammation of the inner eye 8 to 54 months after PPV was evaluated by repeated ocular examinations, as well as by interrogation of referring veterinarians and horse owners. The absence of recurrent inflammation in terms of symptoms of classic uveitis after surgery was considered a success. A total of 55 of 118 horses (46.6 %) had serum antibodies against different serovars of Leptospira (L.) interrogans (≥ 1 : 100). Culture of vitreous humor was positive in 16/118 (13.6 %) patients with ERU. In 49 of 118 horses (41.5 %) and 52 of 134 eyes (38.8 %) leptospiral antibodies were detected in vitreous humor via MAT. L. interrogans serovar Grippotyphosa (48) and L. interrogans serovar Pomona (12) were identified most frequently. A total of 90/118 (76.3 %) horses and 104/134 eyes (77.6 %) remained relapse-free over a period of 8 to 54 months. Forty-one/49 horses (83.7 %) and 44/52 eyes (84.6 %), tested positive for antibodies against L. interrogans via MAT and 49/69 horses (71.0 %) and 60/82 eyes (73.2 %), in which no leptospiral antibodies were detected in vitreous humor, showed no further episodes of ERU (Fishers exact test: P ≥ 0.05). These findings confirm the therapeutic approach to perform a vitrectomy according to the clinical ERU diagnosis irrespective of the leptospiral antibody result.Keywords: horse, equine recurrent uveitis, vitrectomy, leptospira; ophthalmology Zitation: Dorrego Keiter E., Tóth J., Dikker L., Sielhorst J., Schusser G. F. (2017) Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis

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“…There is mounting evidence, that various serovars of Leptospira interrogans are at least the triggering factor for ERU (Roberts et al 1952, Yager et al 1952, Bryans 1955, Roberts 1958, Roberts 1969, Trap 1979, Hathaway et al 1981, Davidson et al 1987, Matthews et al 1987, Sillerud et al 1987, Dwyer et al 1995, Wollanke et al 1998, Wollanke et al 2001, Wollanke 2002, Wollanke et al 2004a, Niedermaier et al 2006, Gilger Salmon et al 2008 and it has been shown, that vaccination with a specific vaccine was successful in preventing new cases in an endemic horse population (Rohrbach et al 2002, Wollanke et al 2004b, Rohrbach et al 2005.…”

Section: Introductionmentioning

confidence: 99%