Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis (ERU)

Keiter, E Dorrego; Töth, J.; Dikker, Lieke; Sielhorst, Jutta; Schusser, G. F.

doi:10.21836/pem20170201

Cited by 8 publications

(11 citation statements)

References 17 publications

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“…In 42/49 horses (83.7 %), tested positive for leptospiral antibodies via MAT, and 49/69 horses, that tested negative, no further uveitis relapses could be detected. According to these findings Dorrego- Keiter et al (2017) stated that a vitrectomy should be performed in accordance to the clinical ERU diagnosis, irrespectively from the leptospiral antibody result of the aqueous humor.…”

Section: Pars Plana Vitrectomy (Ppv)mentioning

confidence: 99%

“…In a recent study of Dorrego- Keiter et al (2017) long-term results of the PPV in relationship to leptospiral antibody detection in vitreous humor samples of 118 horses with equine recurrent uveitis were evaluated. In this retrospective study of 118 ERU diseased patients of different age, gender and breed undiluted vitreous humor was aseptically taken at the beginning of the PPV and examined by culture, as well as by microagglutination test (MAT).…”

Section: Pars Plana Vitrectomy (Ppv)mentioning

confidence: 99%

“…However the fact is that four eyes tested leptospiral negative needed to be removed directly, because the intraocular damage had progressed so far that a vitrectomy was no longer possible. In a recent study of Dorrego- Keiter et al (2017) the aim was to elucidate the relationship between leptospiral antibody detection in vitreous humor and the success of PPV in horses with ERU. This retrospective study of 118 ERU patients confirmed that the therapeutic approach to perform a PPV is in accordance to the clinical ERU diagnosis and irrespective to the result of the leptospiral antibody testing.…”

Section: Figmentioning

confidence: 99%

“…This circumstance requires other promising therapeutic approaches, such as the pars plana vitrectomy and the insertion of a cyclosporine-A (CsA) drug delivery device. Since 1991 the pars plana vitrectomy has been increasingly employed in the treatment of ERU diseased horses (Werry and Gerhards 1991, Winterberg 1997, Frühauf et al 1998, Gilger and Spiess 2006, Dorrego-Keiter et al 2017.…”

Section: Introductionmentioning

confidence: 99%

“…The literature recommends the vitrectomy only for the treatment of horses with a leptospira-associated ERU (Tömördy et al 2010). Despite this suggestion, the clinical experiences and the results described by Dorrego-Keiter et al (2017) indicate that the vitrectomy is effective in MAT-negative cases as well. In 2016 Baake et al analysed the results of indirect and direct procedures to confirm the existence of leptospira using 98 samples of vitreal humor from horses with ERU (MAT, PCR, culture).…”

Section: Introductionmentioning

confidence: 99%

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Clinical experiences after the insertion of a Cyclosporine-A drug delivery device in horses with Equine Recurrent Uveitis

Waid¹,

Töth²,

Buijs³

et al. 2018

PHK

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Several studies have dealt with the etiopathogenesis-, diagnostics as well as the conservative and surgical treatment methods of equine recurrent uveitis (ERU) with different outcomes. Because of potential side effects of applied medication, the risk of doping in the case of sport horses and the problem of future uveitis episodes, a traditional medical treatment is not always feasible.This circumstance requires other promising therapeutic approaches, such as the pars plana vitrectomy (PPV) and the insertion of a cyclosporine-A (CsA) drug delivery device. The literature provides varying perspectives on both of the aforementioned methods. Besides the successful PPV, the cyclosporine-A implant is proposed and applied with an increased frequency due to its nature of being an easier and financially lucrative surgical technique. Currently cyclosporine implants cannot be obtained and applied legally in Germany, therefore any usage is signified as a serious breach of the Medicines Law. According to the literature it appears that the majority of authors consider the PPV to be an effective treatment method only for leptospira positive tested horses, but nor for eyes testing negative for leptospiral antibodies. This retrospective study included 24 ERU patients of different age, gender and breeds that were initially examined by ophthalmological specialists beforehand and treated with suprachoroidal CsA implants. These horses having the CsAI still suffered from uveitis episodes, as the implant only masked inflammatory bouts resulting in a proceeding damage of intraocular structures. This circumstance required another therapeutic approach. Undiluted vitreous humor samples of all of the 24 horses were taken and were tested for specific antibodies against 9 different serovars of Leptospira interrogans by microscopic agglutination test (MAT). The ERU-diseased eyes of 4 horses were removed and in one horse an intrascleral eye prosthesis was inserted. Between 2013 and 2017 19/24 horses with ERU (79.2 %) with CsA implants, still having uveitis episodes, were treated via single port PPV. The outcome of the PPV and the postoperative course of the horses were followed up. The evaluation of efficacy of the PPV was deduced either directly by follow-up examinations (n = 8), photographic documentation and patient records or indirectly by questioning the referring owners (n =11). 14/19 horses (73.7 %) were tested positive for intraocular leptospira antibodies and 5/19 horses (26.3 %) have been tested intraocular MAT negative. The absence of active uveitis was considered a success irrespective of the visual outcome of the surgical treated eyes. A total of 14/19 horses (73.7 %) remained relapse-free over a period of 5 to 63 months. 10/14 horses (71.4 %) with leptospiral antibodies in the vitreous humor had no further uveitis relapses postoperatively, while only 1/5 horses (20 %) tested MAT negative continued to episodes of ERU. The comparison between numbers of horses with positive or negative leptospiral antibodies in vitreous humor in relat...

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Section: Pars Plana Vitrectomy (Ppv)mentioning

confidence: 99%

Section: Pars Plana Vitrectomy (Ppv)mentioning

confidence: 99%

Section: Figmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Clinical experiences after the insertion of a Cyclosporine-A drug delivery device in horses with Equine Recurrent Uveitis

Waid¹,

Töth²,

Buijs³

et al. 2018

PHK

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Recognising and treating uveitis in donkeys

Bradley¹

2022

UK-Vet Equine

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There is a paucity of information in the veterinary literature regarding ophthalmic disease in the donkey. Uveitis is a potentially blinding condition, which warrants prompt diagnosis and treatment. Clinical signs associated with uveitis include epiphora, aqueous flare, miosis, corneal oedema, keratic precipitates and vitreal inflammation, posterior synechiae formation, cataract formation, lens luxation or subluxation, peripapillary scarring and retinal detachment. Treatment is aimed at suppressing the uveal tract inflammation, through the use of both topical and systemic medications. Surgical intervention may also be considered, with appropriate patient selection. This article describes the clinical signs, diagnosis and management of uveitis in the donkey.

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Results of 654 trans-pars plana vitrectomies of equine eyes with recurrent uveitis – follow-up until 18 years after surgery

Wollanke¹,

Gerhards²,

Schinagl³

2021

PHK

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Long-term results of pars plana vitrectomy in relationship to leptospiral antibody detection in vitreous humor in 118 horses with equine recurrent uveitis (ERU)

Cited by 8 publications

References 17 publications

Clinical experiences after the insertion of a Cyclosporine-A drug delivery device in horses with Equine Recurrent Uveitis

Clinical experiences after the insertion of a Cyclosporine-A drug delivery device in horses with Equine Recurrent Uveitis

Recognising and treating uveitis in donkeys

Results of 654 trans-pars plana vitrectomies of equine eyes with recurrent uveitis – follow-up until 18 years after surgery

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