Serum and placental periostin levels in women with early pregnancy loss

Eroğlu, Semra; Colak, Eser; Erinanç, Hilal; Özdemir, Duygu; Ceran, Mehmet Ufuk; Taşdemir, Ümit; Kulaksızoğlu, Sevsen; Özçimen, Emel Ebru

doi:10.1016/j.jri.2020.103138

Cited by 4 publications

(6 citation statements)

References 20 publications

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“…In addition, anxiety and depression in patients receiving IVF treatment may lead to a lower pregnancy rate [ 7 – 9 ]. Unfortunately, the pregnancy loss rate after IVF-ET remains high, and the live birth rate is approximately 20%–30%, which has become an important issue in assisted reproduction treatment [ 10 ]. Pregnancy loss, also called miscarriage or spontaneous abortion, is usually considered as the termination of pregnancy before 20 weeks of gestation [ 11 ], and the causes of pregnancy loss are complicated.…”

Section: Introductionmentioning

confidence: 99%

Case Management Improves Satisfaction, Anxiety, and Depression of Patients with Pregnancy Loss after In Vitro Fertilization and Embryo Transfer

Xia

et al. 2022

Computational and Mathematical Methods in Medicine

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Objective. Pregnancy loss has negative impacts on both the physical and the mental health of expectant mothers, which calls for an in-depth investigation. In this study, we examined the effects of case management on patients with pregnancy loss after in vitro fertilization and embryo transfer (IVF-ET). Methods. 100 participants that had suffered pregnancy loss after IVF-ET-assisted pregnancy from January 2019 to March 2020 were divided into routine care and case management groups, each with 50 cases. For the routine care group, a doctor led the diagnostic and treatment processes and a nurse assisted with the treatment. For the case management group, a nurse led the patient diagnostic and treatment processes and a doctor controlled the diagnosis and treatment plan formulation. Case management models were established according to the comprehensive peripregnancy loss care of patients with pregnancy loss after IVF-ET-assisted pregnancy. The participants’ outcomes (satisfaction, anxiety, and depression) were assessed at the time of pregnancy loss and 1 and 3 months after pregnancy loss during follow-up of the routine care and case management groups. Results. There was no statistical difference between the patients in the two groups with regard to their general information statistics ( P > 0.05 ) or their satisfaction, anxiety, and depression at the time of pregnancy loss ( P > 0.05 ). One month after pregnancy loss, there was no statistical difference in anxiety between the two groups ( P > 0.05 ), but satisfaction was greater and depression was significantly reduced in the case management group compared with the routine care group ( P < 0.05 ). Conclusion. Case management care can have a positive effect on improving the satisfaction, anxiety, and depression of patients that have had pregnancy loss after IVF-ET.

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Section: Introductionmentioning

confidence: 99%

Case Management Improves Satisfaction, Anxiety, and Depression of Patients with Pregnancy Loss after In Vitro Fertilization and Embryo Transfer

Xia

et al. 2022

Computational and Mathematical Methods in Medicine

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“…Morelli et al have compared the serum and endometrial periostin levels between the two groups of spontaneous abortion and voluntary termination of pregnancy and found that women in the group with spontaneous abortion have signi cantly lower levels of periostin in the serum, trophoblast, and decidual tissues [21]. Eroglu et al have found that the levels of serum periostin are remarkably lower in the spontaneous abortion group, while they do not detect differences in tissue expression [23]. Similar ndings have been reported by Freist et al that when the pregnancy loss occurs spontaneously rather than the induced one, the level of periostin is signi cantly reduced [22].…”

Section: Discussionmentioning

confidence: 99%

“…A previous study has pointed out that periostin may be a new serum biomarker of endometrial receptivity and embryoendometrial cross talk at implantation [21]. Recently, study showed that low levels of serum periostin are an indicator of poor implantation, which may cause pregnancy loss in the early stages [22,23]. However, no study has revealed whether the levels of serum periostin on the day of FET affect the pregnancy outcomes.…”

Section: Introductionmentioning

confidence: 99%

The Levels of Serum Periostin on the Day of Frozen-thawed Embryo Transfer Affect the Pregnancy Outcomes

Cai

et al. 2021

Preprint

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Background: Periostin is a secretory extracellular protein that has multiple biological roles. It has been confirmed to play a significant role in embryo implantation and development,placental formation. In our study, we aimed to explore whether the levels of serum periostin on the day of frozen-thawed embryo transfer (FET) affected pregnancy outcomes.Methods: This was a retrospective cohort study consisting of 286 frozen-thawed embryo transfer cycles(FETs). According to pregnancy outcomes, the participants were devided into the pregnant group (n=110) and non-pregnant group (n=176). The concentration of serum periostin was determined by enzyme-linked immunosorbent assay (ELISA).Results: In the pregnant group, the level of serum periostin was dramatically higher compared with the non-pregnant group (41.25 ± 25.77 vs. 30.94 ± 18.28 ng/mL; P<0.05). Multivariate logistic regression analysis demonstrated that the level of serum periostin had a significant effect on the clinical pregnancy (OR=1.03, 95% CI: 1.01, 1.04). The receiver operator characteristic (ROC) curve analysis was performed to assess the predictive value of the serum periostin level (AUC 0.61; 95% CI:0.52 ,0.68). Conclusions: In conclusion, the levels of periostin serum on the day of frozen-thawed embryo transfer affected the pregnancy outcomes for patients who underwent frozen thawed embryo transfer.

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“…Pregnancy is a physiological process that is often accompanied by a variety of complications, and it has significant effects on the physical and mental health in women of reproductive age. Spontaneous abortion is one of the most common pregnancy complications with a clinical incidence of around 15%, in which more than 80% cases occur before 12 weeks, also known as early spontaneous abortion (ESA) 1,2 . Many factors may lead to the occurrence of ESA, including chromosomal abnormalities of the embryo, endocrine disorders of the mother, uterine dysplasia or malformation, immune dysfunction, and reproductive tract infection 2‐6 .…”

Section: Introductionmentioning

confidence: 99%

“…Spontaneous abortion is one of the most common pregnancy complications with a clinical incidence of around 15%, in which more than 80% cases occur before 12 weeks, also known as early spontaneous abortion (ESA). 1,2 Many factors may lead to the occurrence of ESA, including chromosomal abnormalities of the…”

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confidence: 99%

TNFα‐induced abnormal activation of TNFR/NF‐κB/FTH1 in endometrium is involved in the pathogenesis of early spontaneous abortion

Wen

Cheng

Qin

et al. 2022

J Cellular Molecular Medi

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Pregnancy is a physiological process that is often accompanied by a variety of complications, and it has significant effects on the physical and mental health in women of reproductive age.Spontaneous abortion is one of the most common pregnancy complications with a clinical incidence of around 15%, in which more than 80% cases occur before 12 weeks, also known as early spontaneous abortion (ESA). 1,2 Many factors may lead to the occurrence of ESA, including chromosomal abnormalities of the

show abstract

Serum and placental periostin levels in women with early pregnancy loss

Cited by 4 publications

References 20 publications

Case Management Improves Satisfaction, Anxiety, and Depression of Patients with Pregnancy Loss after In Vitro Fertilization and Embryo Transfer

Case Management Improves Satisfaction, Anxiety, and Depression of Patients with Pregnancy Loss after In Vitro Fertilization and Embryo Transfer

The Levels of Serum Periostin on the Day of Frozen-thawed Embryo Transfer Affect the Pregnancy Outcomes

TNFα‐induced abnormal activation of TNFR/NF‐κB/FTH1 in endometrium is involved in the pathogenesis of early spontaneous abortion

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