Serum Adiponectin and Vaspin Levels in Rheumatoid Arthritis

Özgen, Metin; Koca, Süleyman Serdar; Dağlı, Necati; Balın, Mehmet; Üstündağ, Bilal; Işık, Ahmet Turan

doi:10.1016/j.arcmed.2010.08.012

Cited by 65 publications

(53 citation statements)

References 44 publications

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“…16 In humans, however, atherosclerosis-related lowgrade inflammation has been associated with both increased 17 and decreased 11 plasma adiponectin, while there is also evidence that advanced, chronic inflammation may even increase adiponectin levels. 18,19 These conflicting findings suggest that mechanisms related with the underlying disease state may override the regulatory role of inflammation on adiponectin biosynthesis in advanced CVD states. As such, stimulation of adiponectin synthesis in cultured adipocytes by brain natriuretic peptide (BNP) could explain the increased adiponectin levels in patients with HF despite the significant background inflammation, 20 although this link between BNP and adiponectin biosynthesis has never been demonstrated at the level of human AT.…”

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confidence: 77%

Reciprocal Effects of Systemic Inflammation and Brain Natriuretic Peptide on Adiponectin Biosynthesis in Adipose Tissue of Patients With Ischemic Heart Disease

Antonopoulos

Margaritis

Coutinho

et al. 2014

ATVB

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Objective-To explore the role of systemic inflammation in the regulation of adiponectin levels in patients with ischemic heart disease. Approach and Results-In a cross-sectional study of 575 subjects, serum adiponectin was compared between healthy subjects, patients with coronary artery disease with no/mild/severe heart failure (HF), and patients with nonischemic HF. Adiponectin expression and release from femoral, subcutaneous and thoracic adipose tissue was determined in 258 additional patients with coronary artery bypass grafting. Responsiveness of the various human adipose tissue depots to interleukin-6, tumor necrosis factor-α, and brain natriuretic peptide (BNP) was examined by using ex vivo models of human fat. The effects of inducible low-grade inflammation were tested by using the model of Salmonella typhi vaccine-induced inflammation in healthy individuals. In the cross-sectional study, HF strikingly increased adiponectin levels. Plasma BNP was the strongest predictor of circulating adiponectin and its release from all adipose tissue depots in patients with coronary artery bypass grafting, even in the absence of HF. Femoral AT was the depot with the least macrophages infiltration and the largest adipocyte cell size and the only responsive to systemic and ex vivo proinflammatory stimulation (effect reversible by BNP). Low-grade inflammation reduced circulating adiponectin levels, while circulating BNP remained unchanged. Conclusions-This study demonstrates the regional variability in the responsiveness of human adipose tissue to systemic inflammation and suggests that BNP (not systemic inflammation) is the main driver of circulating adiponectin in patients with advanced atherosclerosis even in the absence of HF. Any interpretation of circulating adiponectin as a biomarker should take into account the underlying disease state, background inflammation, and BNP levels.

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confidence: 77%

Reciprocal Effects of Systemic Inflammation and Brain Natriuretic Peptide on Adiponectin Biosynthesis in Adipose Tissue of Patients With Ischemic Heart Disease

Antonopoulos

Margaritis

Coutinho

et al. 2014

ATVB

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“…Changes in vaspin levels have been investigated in many diseases (38)(39)(40)(41)(42). Vaspin was associated with obesity, type 2 diabetes mellitus, rheumatoid arthritis, and systemic inflammation (39,43).…”

Section: Discussionmentioning

confidence: 99%

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

et al. 2016

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The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-α) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-α. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-α (P < 0.008), which declined following treatment (P < 0.025), and lower omentin levels (P < 0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome. (J Oral Sci 58, [465][466][467][468][469][470][471][472][473] 2016)

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“…Although vaspin has been suggested to have several effects on insulin resistance [12][13][14][15], inflammatory process [9], polycystic ovary syndrome [16], osteoarthritis [17], rheumatoid arthritis [18], coronary artery disease [19,20], nonalcoholic fatty liver disease [21,22], and chronic hepatitis C [23], but the exact function of vaspin in the body is not well known and its function in resting metabolic rate (RMR) is even less understood. In addition, the effect of vaspin on metabolism disorder is not clearly known [24].…”

Section: Introductionmentioning

confidence: 99%

Mediatory effect of circulating vaspin on resting metabolic rate in obese individuals

et al. 2015

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Serum Adiponectin and Vaspin Levels in Rheumatoid Arthritis

Cited by 65 publications

References 44 publications

Reciprocal Effects of Systemic Inflammation and Brain Natriuretic Peptide on Adiponectin Biosynthesis in Adipose Tissue of Patients With Ischemic Heart Disease

Reciprocal Effects of Systemic Inflammation and Brain Natriuretic Peptide on Adiponectin Biosynthesis in Adipose Tissue of Patients With Ischemic Heart Disease

The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

Mediatory effect of circulating vaspin on resting metabolic rate in obese individuals

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