The levels of visceral adipose tissue-derived serpin, omentin-1 and tumor necrosis factor-α in the gingival crevicular fluid of obese patients following periodontal therapy

Abstract

The aim of this clinical study was to determine levels of visceral adipose tissue-derived serpin (vaspin), omentin-1, and tumor necrosis factor-alpha (TNF-α) in the gingival crevicular fluid (GCF) of obese and non-obese periodontitis patients following nonsurgical periodontal therapy. Seventy-six subjects were separated into four groups according to periodontal and anthropometric measurements: a periodontal-healthy group, a chronic periodontitis (CP) group, a periodontal-healthy with obesity group, and a CP with obesity group. Nonsurgical periodontal treatment was administered to periodontitis patients. Before treatment and at 6 weeks after treatment, GCF samples were analyzed and clinical periodontal parameters were examined. Enzyme-linked immunosorbent assays were used to measure the levels of vaspin, omentin-1, and TNF-α. Obese and non-obese CP patients displayed higher levels of vaspin and TNF-α (P < 0.008), which declined following treatment (P < 0.025), and lower omentin levels (P < 0.008), which increased after treatment (P < 0.025). There was a negative correlation between the total amount of vaspin and omentin-1 in all groups. Obese and non-obese patients had opposing levels of vaspin and omentin-1 in the GCF; therefore, these may represent diagnostic and prognostic indicators of periodontal disease and therapeutic outcome. (J Oral Sci 58, [465][466][467][468][469][470][471][472][473] 2016)

Study of salivary and serum vaspin and total antioxidants in anorexia nervosa

“…In the analyzes carried out by Pradeep et al in 2015, similar relationships were also found in the concentrations of this protein in the tear fluid [15]. In addition, the levels of vaspin were correlated positively with the clinical signs of the advanced periodontal disease, i.e., with clinical attachment level (CAL) and gingival index (GI) [15,59]. In one of them, positive correlations between the level of VASP and the number of deep pockets were also found [59].…”

“…Some investigations have suggested that VASP has a potential role as an inflammatory biomarker of chronic periodontitis and can be altered after non-surgical treatment in the oral cavity [17]. Regarding oral cavity and vaspin, in three studies in which gingival crevicular fluid (GCF) concentrations were determined in patients with moderate severity of periodontitis, higher levels of this protein were found relative to the reference groups [15,17,59]. In the analyzes carried out by Pradeep et al in 2015, similar relationships were also found in the concentrations of this protein in the tear fluid [15].…”

“…In addition, the levels of vaspin were correlated positively with the clinical signs of the advanced periodontal disease, i.e., with clinical attachment level (CAL) and gingival index (GI) [15,59]. In one of them, positive correlations between the level of VASP and the number of deep pockets were also found [59]. The degree of advancement of periodontitis in studies of Balli et al (2016) has been described in relation to clinical signs of inflammation as a red color and the swelling of the gingival margin, and GI greater than 2, CAL greater than 5 mm, and bone loss affecting 30% of the existing teeth [59].…”

Association between obesity and adipokines levels in saliva and gingival crevicular fluid: A systematic review and meta‐analysis

“…No study assessed vaspin levels in saliva, although two studies analyzed vaspin in GCF. One found significantly higher levels in individuals with obesity in comparison with nonobese individuals.…”

“…No study assessed vaspin levels in saliva, although two studies analyzed vaspin in GCF. One found significantly higher levels in individuals with obesity in comparison with nonobese individuals. The other study demonstrated a positive, but weak, correlation between BMI and vaspin concentration in GCF.…”