Serotype of <i>Mycobacterium avium–Mycobacterium intracellulare</i> Complex That Caused Lung Disease in Japan

Nemoto, Hisashi; Yugi, Hiroyuki; Tsukamura, M

doi:10.1111/j.1348-0421.1975.tb00849.x

Cited by 9 publications

(5 citation statements)

References 7 publications

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“…In the present study, more strains were collected from various places and serotyped (all strains isolated in the hospitals participating in the Mycobacteriosis Research Group of the National Chest Hospitals were identified in the National Chubu Hospital). The results were similar to those obtained in the previous study (6). The serotypes shown by relatively many strains were 9 (Watson), 15 (Dent), 16 (Yandle), and 18 (Altman) in both studies (Table 1).…”

Section: Discussionsupporting

confidence: 81%

“…Previously we reported on the distribution of serotypes in strains that cause lung disease in this country (6). In the present study, more strains were collected from various places and serotyped (all strains isolated in the hospitals participating in the Mycobacteriosis Research Group of the National Chest Hospitals were identified in the National Chubu Hospital).…”

Section: Discussionmentioning

confidence: 99%

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1982

Microbiology and Immunology

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Some relationships among Schaefer's serotypes and biological and biochemical characteristics were observed in strains of the Mycobacterium aviumMycobacterium intracellulare complex.Strains belonging to serotypes 2 and 16 lacked the capacity to utilize n-and iso-butanols as the sole source of carbon in the presence of ammoniacal nitrogen.However, strains of serotype 2 grew at 45 C and lacked arylsulfatase activity (after 14 days), whereas strains of serotype 16 failed to grow at 45 C and showed positive arylsulfatase activity. Strains belonging to serotypes 8, 9, and 15 grew at 45 C, utilized n-and iso-butanols, and showed arylsulfatase activity.An attempt to differentiate subgroups of the Mycobacterium avium-Mycobacterium intracellulare-Mycobacterium scrofulaceum complex (M. avium complex (8,9)), especially of M. avium plus M. intracellulare, was first carried out by Birn et al (I). However, at that time, no distinct subgrouping could be obtained. Schaefer (7) differentiated more than 20 serotypes in this complex, and Brennan et al (3) and Brennan and Goren (2) observed an intimate relationship between Schaefer's antigen (serotype) and Marks' lipid pattern (5). Tsukamura and Mizuno (II) also found that some serotypes correlate with some thin-layer chromatographic patterns of M. avium complex after incubation with [35S]methionine. In the present work, we studied the relationship between the serotype and the biological and biochemical characteristics of strains of M. avium and M. intracellulare. METHODSA total of 126 strains were studied. The serotypes of all strains were determined by the method of Schaefer (7) and numbered according to the scheme of Wolinsky and Schaefer (12).

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confidence: 81%

Section: Discussionmentioning

confidence: 99%

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1982

Microbiology and Immunology

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“…Sci. 63(7): 827-829, 2001 Mycobacterium avium is widely distributed in the environment and is the causative agent of atypical mycobacteriosis in humans and animals [6,8]. In swine, most of the lesions are formed in the mesenteric or mandibular lymph nodes, and the disseminated lesions are occasionally observed in the liver, spleen, and lungs [3,5].…”

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Lymphoproliferative Responses in Pigs Infected with Mycobacterium avium.

Iwakiri

Toshimasu

et al. 2001

The Journal of Veterinary Medical Science

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ABSTRACT. Naturally infected cases of swine mycobacteriosis were divided into two groups, localized infection (LI) and disseminated infection (DI). Lymphoproliferative response (LPR) was then examined to estimate their immunological states. Both control and LI groups showed strong response to Concanavalin A (Con A) and phytohemagglutinin (PHA) in the LPR, and lymphocytes recovered from the LI responded well to purified protein derived from M. avium (PPD). On the other hand, the DI group showed weak response to both Con A and PHA, despite their strong response to PPD stimulation. These data suggest that the low LPR to Con A and PHA observed in the DI groups was probably not due to the general unresponsiveness of T-cells. KEY WORDS: lymphoproliferative response (LPR), Mycobacterium avium, swine.J. Vet. Med. Sci. 63(7): 827-829, 2001 Mycobacterium avium is widely distributed in the environment and is the causative agent of atypical mycobacteriosis in humans and animals [6,8]. In swine, most of the lesions are formed in the mesenteric or mandibular lymph nodes, and the disseminated lesions are occasionally observed in the liver, spleen, and lungs [3,5]. The organism apparently enters through the tonsils or the lining of the intestine, and then passes into the bloodstream through the portal circulation, subsequently causing miliary lesions in the liver and other organs [11]. Outbreaks of swine mycobacteriosis were detected at the Meat Inspection Centers of Japan. We found 13 cases of systemic infections among 1,588 pigs, which were diagnosed as having atypical mycobacteriosis. There is little knowledge about the immnopathological mechanism by which systemic infection occurs in only a few individuals and what factor (s) regulate the resistance or susceptibility to M.avium infection in pigs. It has generally been thought that suppression of cell-mediated immune function converts local tuberculous lesions into miliary tuberculosis, and that a decrease in the T lymphocyte population deteriorates the equilibrium of this disease. It has been reported that in vitro swine lymphocyte immunostimulation assay with purified protein derivative from M.avium (PPD) might be useful in the diagnosis of individuals with M.avium infection [1]. In the present study we examined the difference in cell-mediated immune responses in pigs with localized and systemic mycobacteriosis infections by evaluating the lymphoproliferative response (LPR) in order to certify the immune state.All pigs used in this investigation were two-or three-way crossbreeds (LWD) raised on commercial and conventional farms, and which were 6 months of age and about 100 kg in weight. The discovery and examination of M.aviuminfected individuals was performed at three Meat Inspection Centers in Miyazaki Prefecture. According to the severity of the disease, they were divided into two categories. The individuals in which tuberculous granuloma lesions were widely distributed in the liver and/or spleen were categorized as cases of disseminated infection (DI), whereas the p...

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“…During the experimental period, fecal specimens were obtained from all chickens once a week and submitted for isolation of mycobacterium. Alkaline treatment of fecal specimens was Mycobacterium avium complex (MAC) is the agent of atypical mycobacteriosis in man and animals [1,2,6,13,18,19,28]. MAC is composed of 28 serovars [23,24,29], from 1 to 3 (as M. avium) and 4 to 28 (as M. intracellulare).…”

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“…It was reported that M. avium serovar 9 was isolated from AIDS patients at a rate of 7.3% during 1980 and 1985 in the United States [31]. In Japan, the isolation rate of serovar 9 was shown to be 13.0% in patients with atypical mycobacteriosis between 1972 and 1990 [19]. Serovar 9 was also detected at a rate of 13.8% among swine strains derived from a nation-wide scale survey by the Japan Association of Meat Inspection Laboratories in 1983 (Katsube Y., unpublished).…”

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Pathogenicity of Mycobacterium avium Complex Serovar 9 Isolated from Painted Quail (Excalfactoria chinensis).

Morita¹,

Maruyama

Hashizaki

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. Avian tuberculosis accompanied with many tubercular lesions in the liver and spleen was found in a painted quail at a zoological garden in Japan. Mycobacterium avium complex (MAC) serovar 9 without insertion sequence of IS901 was isolated from the liver (1.3 × 10 8 CFU/g), oviduct (9.4 × 10 7 CFU/g), and intestine (1.5 × 10 5 CFU/g). The isolates were inoculated intravenously to chickens. The inoculated chickens showed clinical symptoms of avian tuberculosis. Birds are susceptible to MAC serovar 9 without IS901.-KEY WORDS: avian tuberculosis, Mycobacterium avium complex serovar 9, painted quail.

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Serotype of Mycobacterium avium–Mycobacterium intracellulare Complex That Caused Lung Disease in Japan

Cited by 9 publications

References 7 publications

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Lymphoproliferative Responses in Pigs Infected with Mycobacterium avium.

Pathogenicity of Mycobacterium avium Complex Serovar 9 Isolated from Painted Quail (Excalfactoria chinensis).

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