Serotonina e controle hipotalâmico da fome: uma revisão

Abstract

This paper reviews involvement of the serotonergic system in the control of food intake and satiety. It is of great interest to understand the relevance of this system for physiological control of energy balance and obesity. Over 35 years of research suggest that serotonin (5-HT) plays an important role in satiety. Thus, the serotonergic system has been a viable target for weight control. The 5-HT has control over hunger and satiety through different receptors with distinct functions. The 5-HT2C receptor may be more important in the relationship between food intake and energy balance. This review will discuss the mechanisms of the serotonergic system involved in the control of food intake and satiety.

Adesão à dieta por idosos com síndrome metabólica assistidos na Estratégia Saúde da Família: frequência e associação com depressão

“…Qualquer desregulação nesses sistemas, ou até mesmo a deficiência ou diminuição dos receptores para esses peptídeos, pode influenciar o humor e o comportamento. No enfrentamento de situações estressoras ou de desgaste emocional, indivíduos que sofrem algum transtorno de humor podem aumentar o consumo de alimentos altamente palatáveis, como doces e carboidratos, de forma a compensar as deficiências provocadas pela desregulação desses hormônios [34][35][36][37].…”

A theory of social thermoregulation in human primates

“…This is particularly important in habitats where food availability fluctuates or is unpredictable ( Schneider et al, 2013 ). In species representing every vertebrate taxa and even in some invertebrates, many putative “satiety” or “hunger” modulators including oxytocin and serotonin, function to schedule ingestive behavior in order to optimize reproductive success in environments where energy availability fluctuates ( de Matos Feijó et al, 2011 ; Schneider et al, 2013 ). The same modulators such as oxytocin and serotonin are also implicated in thermoregulation.…”

Serotonin Receptors in Hippocampus

“…Serotonin influences body temperature, breathing rhythms (respiratory system), heart rate (cardiovascular function in general), eating and bowel motility (gastrointestinal system), ejaculatory latency and bladder control, muscle contraction/relaxation and locomotion, sleep, arousal, pain and sensory perception, emotions, and cognition [2, 5, 20] with a well-known signaling role in immune cells [21]. …”

“…Knockout phenotype for 5-HT 2A shows decreased, anxiety while the one for 5-HT 2C shows increased appetite, overweight, and cognitive impairment. Serotonin receptor 5-HT 2C is probably the most important receptor related to food intake and energy balance (satiety and obesity), with viable targeting for weight control [20]. …”