Serotonin1B receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons

Nagata, Ai; Nakayama, Keiichi I.; Nakamura, Sumiko; Mochizuki, Ayako; Gemba, Chikako; Aoki, Risa; Dantsuji, Masanori; Maki, Koutaro; Inoue, Tomio

doi:10.1016/j.brainresbull.2019.05.001

Cited by 7 publications

(8 citation statements)

References 50 publications

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“…The authors suggested that pre‐synaptic 5‐HT1B receptors were involved in the inhibition of the excitatory synaptic inputs from mesencephalic trigeminal nucleus afferents to masseter motoneurons 36 16,28,35,36 . All these considerations seem to support the results obtained in the present study that indicate lower serotonin levels in patients with severe SB and thus increased potentially pathological motor activity of masticatory muscles.…”

Section: Discussionsupporting

confidence: 86%

“…36 The described results show that higher serotonin levels might be involved in maintaining the balance of motor activity. 16,28,35,36 All these considerations seem to support the results obtained in the present study that indicate lower serotonin levels in patients with severe SB and thus increased potentially pathological motor activity of masticatory muscles.…”

Section: Discussionmentioning

confidence: 70%

“…16,35 The results reported by Nagata et al also show a similar association. 36 The authors examined the effects of serotonin on the excitatory synaptic inputs from mesencephalic trigeminal nucleus afferents to masseter motoneurons and reported that bath application of serotonin in rat brain tissues reduced the peak amplitude of excitatory post-synaptic potentials evoked in masseter motoneurons. The authors suggested that presynaptic 5-HT1B receptors were involved in the inhibition of the excitatory synaptic inputs from mesencephalic trigeminal nucleus afferents to masseter motoneurons.…”

Section: Discussionmentioning

confidence: 99%

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Lower serotonin levels in severe sleep bruxism and its association with sleep, heart rate, and body mass index

Smardz

Martynowicz

Wojakowska

et al. 2021

J of Oral Rehabilitation

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Background Sleep bruxism (SB) is a complex behaviour that seems to be associated with the serotoninergic pathway. Objectives This exploratory research aimed to evaluate the levels of serotonin in individuals with sleep bruxism diagnosed by video polysomnography. The study also evaluated whether the levels of serotonin were associated with body mass index, heart rate, and sleep parameters. Methods The study participants were adults hospitalised in the Department and Clinic of Internal Medicine, Occupational Diseases, Hypertension and Clinical Oncology at the Wroclaw Medical University. They underwent a single‐night video polysomnography during which sleep and SB parameters and heart rate were evaluated. Additionally, body mass index and blood serotonin levels were evaluated for each patient. Results A total of 105 patients were included in this study (80 women and 25 men). All the patients were Caucasians aged 18–63 years, with a mean age ± (standard deviation) of 33.43± 10.8 years. Seventy‐five patients (71.43%) presented sleep bruxism (bruxism episodes index ≥2) and 30 (28.57%) did not. Fifty patients (47.62%) presented severe sleep bruxism (bruxism episodes index >4). The results showed that lower blood serotonin levels were associated with severe sleep bruxism; increased bruxism episodes index, rapid eye movement sleep, and body mass index; and decreased maximal pulse. Conclusion Severe sleep bruxism and the associated phenomena seem to co‐occur with lower blood serotonin levels. The study supports the hypothesis on the relationship between the serotoninergic pathway and sleep bruxism.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 70%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Lower serotonin levels in severe sleep bruxism and its association with sleep, heart rate, and body mass index

Smardz

Martynowicz

Wojakowska

et al. 2021

J of Oral Rehabilitation

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“…After injury, the Tg(tph2:GFP) fish were treated with the potent and highly selective 5-HT 1B agonist, CP 93129 dihydrochloride (Tocris) 82 . The drug was stored as a stock solution (100 mM) in DMSO (Sigma-Aldrich).…”

Section: Methodsmentioning

confidence: 99%

An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish

et al. 2021

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Spinal cord injury (SCI) interrupts long-projecting descending spinal neurons and disrupts the spinal central pattern generator (CPG) that controls locomotion. The intrinsic mechanisms underlying re-wiring of spinal neural circuits and recovery of locomotion after SCI are unclear. Zebrafish shows axonal regeneration and functional recovery after SCI making it a robust model to study mechanisms of regeneration. Here, we use a two-cut SCI model to investigate whether recovery of locomotion can occur independently of supraspinal connections. Using this injury model, we show that injury induces the localization of a specialized group of intraspinal serotonergic neurons (ISNs), with distinctive molecular and cellular properties, at the injury site. This subpopulation of ISNs have hyperactive terminal varicosities constantly releasing serotonin activating 5-HT1B receptors, resulting in axonal regrowth of spinal interneurons. Axon regrowth of excitatory interneurons is more pronounced compared to inhibitory interneurons. Knock-out of htr1b prevents axon regrowth of spinal excitatory interneurons, negatively affecting coordination of rostral-caudal body movements and restoration of locomotor function. On the other hand, treatment with 5-HT1B receptor agonizts promotes functional recovery following SCI. In summary, our data show an intraspinal mechanism where a subpopulation of ISNs stimulates axonal regrowth resulting in improved recovery of locomotor functions following SCI in zebrafish.

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“…The low force generated by motor units in CFS subjects is known to result from muscle membrane dysfunction caused by central neural dysregulation [ 27 ]. The 5-HT hyperactivity in the CNS is the most well-known alteration in neurotransmitters that inhibits proprioceptive sensory and muscular contractions [ 28 ]. Ginseng improves physical function in both healthy individuals and subjects complaining of fatigue [ 14 , 29 ].…”

Section: Discussionmentioning

confidence: 99%

Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model

et al. 2021

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Central fatigue, which is neuromuscular dysfunction associated with neurochemical alterations, is an important clinical issue related to pathologic fatigue. This study aimed to investigate the anti-central fatigue effect of Korean red ginseng (KRG) and its underlying mechanism. Male BALB/c mice (8 weeks old) were subjected to periodic sleep deprivation (SD) for 6 cycles (forced wakefulness for 2 days + 1 normal day per cycle). Simultaneously, the mice were administered KRG (0, 100, 200, or 400 mg/kg) or ascorbic acid (100 mg/kg). After all cycles, the rotarod and grip strength tests were performed, and then the changes regarding stress- and neurotransmitter-related parameters in serum and brain tissue were evaluated. Six cycles of SD notably deteriorated exercise performance in both the rotarod and grip strength tests, while KRG administration significantly ameliorated these alterations. KRG also significantly attenuated the SD-induced depletion of serum corticosterone. The levels of main neurotransmitters related to the sleep/wake cycle were markedly altered (serotonin was overproduced while dopamine levels were decreased) by SD, and KRG significantly attenuated these alterations through relevant molecules including brain-derived neurotropic factor and serotonin transporter. This study demonstrated the anti-fatigue effects of KRG in an SD mouse model, indicating the clinical relevance of KRG.

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Serotonin1B receptor-mediated presynaptic inhibition of proprioceptive sensory inputs to jaw-closing motoneurons

Cited by 7 publications

References 50 publications

Lower serotonin levels in severe sleep bruxism and its association with sleep, heart rate, and body mass index

Lower serotonin levels in severe sleep bruxism and its association with sleep, heart rate, and body mass index

An injury-induced serotonergic neuron subpopulation contributes to axon regrowth and function restoration after spinal cord injury in zebrafish

Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model

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