Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model

Kang, Ji-Yun; Kim, Doyoung; Lee, Jin-Seok; Hwang, Seung-Ju; Kim, Geon-Ho; Hyun, Sun Hee; Son, Chang‐Gue

doi:10.3390/nu13093121

Cited by 10 publications

(9 citation statements)

References 50 publications

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“…Seven-month-old SAMP8 exhibited characteristics of aging such as weight loss and decreased motor function, as well as symptoms of fatigue such as decreased activity. Furthermore, several blood biomarkers, which are known to increase with fatigue, were increased in SAMP8, supporting the idea that they were fatigued [ 32 , 33 ]. Interestingly, there was an increase in IL-1β and a decrease in IL-1RA, both of which are believed to play an important role in fatigue, in both the brain and muscle of aged SAMP8.…”

Section: Discussionmentioning

confidence: 69%

“…In the present study, even though NYT administration was found to reduce fatigue-like conditions, it had no effect on blood biomarkers ( S4 Fig ). Blood biomarkers are also important indicators, and increased biomarkers are associated with fatigue [ 32 , 33 , 47 ]. However, the results of the present study were inconsistent with those of previous studies.…”

Section: Discussionmentioning

confidence: 99%

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Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

Otsuka,

Matsuzaki,

Kakimoto

et al. 2024

PLoS ONE

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Fatigue can lead to several health issues and is particularly prevalent among elderly individuals with chronic inflammatory conditions. Ninjin’yoeito, a traditional Japanese herbal medicine, is used to address fatigue and malaise, anorexia, and anemia. This study aimed to examine whether relieving inflammation in the brain and skeletal muscle of senescence-accelerated mice prone 8 (SAMP8) could reduce fatigue-like conditions associated with aging. First, SAMP8 mice were divided into two groups, with and without ninjin’yoeito treatment. The ninjin’yoeito-treated group received a diet containing 3% ninjin’yoeito for a period of 4 months starting at 3 months of age. At 7 months of age, all mice underwent motor function, treadmill fatigue, and behavioral tests. They were then euthanized and the skeletal muscle weight, muscle cross-sectional area, and concentration of interleukin (IL)-1β and IL-1 receptor antagonist (IL-1RA) in both the brain and skeletal muscle were measured. The results showed that the ninjin’yoeito-treated group had higher motor function and spontaneous locomotor activity than the untreated group did and ran for significantly longer in the treadmill fatigue test. Moreover, larger muscle cross-sectional area, lower IL-1β concentrations, and higher IL-1RA concentrations were observed in both the brain and skeletal muscle tissues of the ninjin’yoeito-treated group than in the untreated group. The results suggest that ninjin’yoeito improves age-related inflammatory conditions in both the central and peripheral tissues and reduces fatigue.

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Section: Discussionmentioning

confidence: 69%

Section: Discussionmentioning

confidence: 99%

Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

Otsuka,

Matsuzaki,

Kakimoto

et al. 2024

PLoS ONE

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“…Panax ginseng, in the family Araliaceae, is considered as one of the most frequently employed medicinal herbs and functional foods [184,185]. In a randomized, placebocontrolled, crossover study, daily consumption of 3 g of Korean red ginseng (KRG) for 4 weeks was shown to improve daytime contrast sensitivity and ocular pain in glaucoma patients [186].…”

Section: Panax Ginseng-ginsenosidementioning

confidence: 99%

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

et al. 2022

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Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. In addition to mechanical and vascular dysfunctions of the eye, oxidative stress, neuroinflammation and excitotoxicity have also been implicated in the pathogenesis of glaucoma. Hence, the use of natural products with antioxidant and anti-inflammatory properties may represent an alternative approach for glaucoma treatment. The present review highlights recent preclinical and clinical studies on various natural products shown to possess neuroprotective properties for retinal ganglion cells, which thereby may be effective in the treatment of glaucoma. Intraocular pressure can be reduced by baicalein, forskolin, marijuana, ginsenoside, resveratrol and hesperidin. Alternatively, Ginkgo biloba, Lycium barbarum, Diospyros kaki, Tripterygium wilfordii, saffron, curcumin, caffeine, anthocyanin, coenzyme Q10 and vitamins B3 and D have shown neuroprotective effects on retinal ganglion cells via various mechanisms, especially antioxidant, anti-inflammatory and anti-apoptosis mechanisms. Extensive studies are still required in the future to ensure natural products’ efficacy and safety to serve as an alternative therapy for glaucoma.

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“…[ 14 ]. To date, numerous studies have revealed various beneficial effects of P. ginseng and its derivatives, including ginsenosides, for the manipulation of fatigue [ 15 ], diabetes [ 16 ], chronic pain [ 17 ], and systemic inflammation [ 18 ].…”

Section: Introductionmentioning

confidence: 99%

Ginseng Sprouts Attenuate Mortality and Systemic Inflammation by Modulating TLR4/NF-κB Signaling in an LPS-Induced Mouse Model of Sepsis

Hwang

Wang

Lee

et al. 2023

IJMS

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Sepsis leads to multi-organ failure due to aggressive systemic inflammation, which is one of the main causes of death clinically. This study aimed to evaluate whether ginseng sprout extracts (GSE) can rescue sepsis and explore its underlying mechanisms. C57BL/6J male mice (n = 15/group) were pre-administered with GSE (25, 50, and 100 mg/kg, p.o) for 5 days, and a single injection of lipopolysaccharide (LPS, 30 mg/kg, i.p) was administered to construct a sepsis model. Additionally, RAW264.7 cells were treated with LPS with/without GSE/its main components (Rd and Re) to explain the mechanisms corresponding to the animal-derived effects. LPS injection led to the death of all mice within 38 h, while GSE pretreatment delayed the time to death. GSE pretreatment also notably ameliorated LPS-induced systemic inflammation such as histological destruction in both the lung and liver, along with reductions in inflammatory cytokines, such as TNF-α, IL-6, and IL-1β, in both tissues and serum. Additionally, GSE markedly diminished the drastic secretion of nitric oxide (NO) by suppressing the expression levels of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) in both tissues. Similar changes in TNF-α, IL-1β, NO, iNOS, and COX2 were observed in LPS-stimulated RAW264.7 cells, and protein expression data and nuclear translocation assays suggested GSE could modulate LPS-binding protein (LBP), Toll-like receptor 4 (TLR4), and NF-κB. Ginsenoside Rd could be a major active component in GSE that produces the anti-sepsis effects. Our data support that ginseng sprouts could be used as an herbal resource to reduce the risk of sepsis. The corresponding mechanisms may involve TLR4/NF-κB signaling and a potentially active component.

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Korean Red Ginseng Ameliorates Fatigue via Modulation of 5-HT and Corticosterone in a Sleep-Deprived Mouse Model

Cited by 10 publications

References 50 publications

Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

Ninjin’yoeito reduces fatigue-like conditions by alleviating inflammation of the brain and skeletal muscles in aging mice

Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

Ginseng Sprouts Attenuate Mortality and Systemic Inflammation by Modulating TLR4/NF-κB Signaling in an LPS-Induced Mouse Model of Sepsis

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