Serotonin inhibits the induction of NMDA receptor-dependent long-term potentiation in the rat primary visual cortex

Kim, Hyun-Sok; Jang, Hyun‐Jong; Cho, Kwang Hyun; Hahn, Sang June; Kim, Myung-Jun; Yoon, Shin Hee; Jo, Yang-Hyeok; Kim, Myung-Suk; Rhie, Duck-Joo

doi:10.1016/j.brainres.2006.05.046

Cited by 39 publications

(47 citation statements)

References 36 publications

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“…In a previous study, we reported an age-dependent decline of both LTP and LTD during the critical period in the rat visual cortex and the decrease in long-term synaptic plasticity was closely related to the degree of inhibitory influence [28]. In another study, we confirmed the inhibitory effect of 5-HT on LTP induction [29]. However, the effect of 5-HT on LTD induction in the visual cortex is yet to be reported despite the known importance of LTD in OD plasticity [30].…”

Section: Introductionsupporting

confidence: 67%

“…In 5-week-old rats, LTD was completely inhibited by 10 μM 5-HT. Although activation of both 5-HT1A and 5-HT2 receptors were required to inhibit the induction of LTP [29], activation of the 5-HT2 receptor alone was sufficient to block the induction of LTD. Reportedly, 5-HT1A receptors exert an inhibitory effect on LTP via the suppression of NMDAR [25,36].…”

Section: Discussionmentioning

confidence: 96%

“…An increase in 5-HT content in the rat primary visual cortex during the critical period reportedly is important in the developmental decrease in LTP [27,29]. To further elucidate the role of 5-HT, the effect of 5-HT on LTD induction was investigated by bath application of 5-HT.…”

Section: -Ht Inhibition On the Induction Of Ltdmentioning

confidence: 99%

“…Previously, we reported that 5-HT content increased during the critical period in the visual cortex and that the depletion of endogenous 5-HT in visual cortical slices by 2-hour incubation of slices with PCA (10 μM) reinstated LTP in 5-week-old rats [29]. Thus, the effect of 5-HT depletion by incubation of slices with PCA was investigated to elucidate the role of endogenous 5-HT on LTD induction.…”

Section: Effect Of 5-ht Depletion On the Induction Of Ltdmentioning

confidence: 99%

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Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

Jang

Cho

Park

et al. 2010

Korean J Physiol Pharmacol

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Long-term potentiation (LTP) and long-term depression (LTD) have both been studied as mechanisms of ocular dominance plasticity in the rat visual cortex. In a previous study, we suggested that a developmental increase in serotonin [5-hydroxytryptamine (5-HT)] might be involved in the decline of LTP, since 5-HT inhibited its induction. In the present study, to further understand the role of 5-HT in a developmental decrease in plasticity, we investigated the effect of 5-HT on the induction of LTD in the pathway from layer 4 to layer 2/3. LTD was inhibited by 5-HT (10 μM) in 5-week-old rats. The inhibitory effect was mediated by activation of 5-HT2 receptors. Since 5-HT also regulates the development of visual cortical circuits, we also investigated the role of 5-HT on the development of inhibition. The development of inhibition was retarded by chronic (2 weeks) depletion of endogenous 5-HT in 5-week-old rats, in which LTD was reinstated. These results suggest that 5-HT regulates the induction of LTD directly via activation of 5-HT2 receptors and indirectly by regulating cortical development. Thus, the present study provides significant insight into the roles of 5-HT on the development of visual cortical circuits and on the age-dependent decline of long-term synaptic plasticity.

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Section: Introductionsupporting

confidence: 67%

Section: Discussionmentioning

confidence: 96%

Section: -Ht Inhibition On the Induction Of Ltdmentioning

confidence: 99%

Section: Effect Of 5-ht Depletion On the Induction Of Ltdmentioning

confidence: 99%

See 2 more Smart Citations

Effects of Serotonin on the Induction of Long-term Depression in the Rat Visual Cortex

Jang

Cho

Park

et al. 2010

Korean J Physiol Pharmacol

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“…Thus, the critical period of layer IV plasticity likely involves changes downstream from the activation of NMDARs. In layer II/III, however, we propose that the machinery supporting synaptic plasticity is preserved in adults, but the induction is highly constrained by recruitment of inhibitory circuits and the action of neuromodulators (Edagawa et al, 2001;Kim et al, 2006), which may mask the ongoing presence of synaptic plasticity (Kirkwood et al, 1997;Yoshimura et al, 2003).…”

Section: Discussionmentioning

confidence: 94%