Seroprevalence of Peste Des Petits Ruminants Virus from Samples Collected in Different Regions of Tanzania in 2013 and 2015

Kgotlele, Tebogo; Torsson, Emeli; Kasanga, Christopher J.

doi:10.4172/2157-7579.1000394

Cited by 10 publications

(16 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The overall seroprevalence of PPR in this study was 74.6%. This seroprevalence is in line with findings from a recent study that analyzed samples from 14 regions of Tanzania, with Arusha region having an overall seroprevalence of 71.1% (Kgotlele et al 2016). Other studies done in northern Tanzania have found PPR seroprevalence of 45.5% in 2008 (Swai et al 2009) and 22.1% in 2008 .…”

Section: Discussionsupporting

confidence: 90%

See 1 more Smart Citation

Detection of peste des petits ruminants and concurrent secondary diseases in sheep and goats in Ngorongoro district, Tanzania

Kgotlele

Chota

Chubwa³

et al. 2018

Comp Clin Pathol

Self Cite

View full text Add to dashboard Cite

Small ruminants play an important role in the livelihoods of resource-constrained communities. This study was initiated because of a massive outbreak of a respiratory disease in sheep and goats in Loliondo area in Ngorongoro district of Arusha region in Tanzania in 2016. During flock examination, a total of 240 serum samples and 61 nasal swabs were collected. Antibodies to small ruminant morbillivirus, causative agent of peste des petits ruminants (PPR), were detected from sera using a competitive enzymelinked immunosorbent assay. A multiplex reverse transcription real-time polymerase chain reaction assay was used to detect four pathogens: small ruminant morbillivirus, Mycoplasma capricolum subspecies capripneumoniae, Pasteurella multocida, and Capripoxvirus from the nasal swabs. Overall seroprevalence of PPR was 74.6%, with all four pathogens detected from nasal swabs. Co-infections of small ruminant morbillivirus and Mycoplasma capricolum subspecies capripneumoniae, small ruminant morbillivirus and Capripoxvirus, small ruminant morbillivirus and Pasteurella multocida, and Mycoplasma capricolum subspecies capripneumoniae and Capripoxvirus were also detected. Presence of PPR and the other diseases in this study provided insight into the severity of the outbreak in sheep and goats in Ngorongoro district. Thus, laboratory confirmation is critical for prompt and appropriate interventions to be made for control of diseases in sheep and goats with similar clinical signs. The findings also call for research into development of combined vaccines targeting common diseases of small ruminants in Tanzania.

show abstract

Section: Discussionsupporting

confidence: 90%

“…In East Africa, PPR was detected in Kenya and Uganda in 2007, while in Tanzania, it was officially confirmed in 2008 (Kivaria et al 2009;Swai et al 2009). The disease is considered endemic in Tanzanian domestic sheep and goat populations (Torsson et al 2017;Kgotlele et al 2016).…”

Section: Introductionmentioning

confidence: 99%

Detection of peste des petits ruminants and concurrent secondary diseases in sheep and goats in Ngorongoro district, Tanzania

Kgotlele

Chota

Chubwa³

et al. 2018

Comp Clin Pathol

Self Cite

View full text Add to dashboard Cite

show abstract

“…In southern Tanzania, in the Mtwara region bordering Mozambique, 31% of sampled small ruminants had antibodies to PPRV [47]. A recent study analysing samples from 14 different regions of Tanzania described an overall seroprevalence of 27.1%, with regions varying from 2.4% (Kagera) to 72.8% (Morogoro), demonstrating the varying level of seroprevalence within the country [23]. …”

Section: Discussionmentioning

confidence: 99%

“…PPR was first confirmed in Tanzania in 2008 [21], but a retrospective study on samples collected in the northern districts found antibodies to PPRV were probably already present in 2004 [22]. The disease has since spread to the southern parts of the country and is now considered endemic in the domestic, small ruminant population in the whole country [23–25]. CCPP, FMD, BT, and BVD are endemic in Tanzania [24], however studies on FMD and BT have only been performed on large ruminants.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence and risk factors for peste des petits ruminants and selected differential diagnosis in sheep and goats in Tanzania

Torsson

Berg

Misinzo

et al. 2017

Infection Ecology & Epidemiology

Self Cite

View full text Add to dashboard Cite

Introduction: Livestock husbandry is critical for food security and poverty reduction in a low-income country like Tanzania. Infectious disease is one of the major constraints reducing the productivity in this sector. Peste des petits ruminants (PPR) is one of the most important diseases affecting small ruminants, but other infectious diseases may also be present. Objective: The objective of this study was to determine the seroprevalence and risk factors for exposure to PPR, contagious caprine pleuropneumonia (CCPP), foot-and-mouth disease (FMD), bluetongue (BT), and bovine viral diarrhoea (BVD) in sheep and goats in Tanzania. Methods: Serum samples were collected in 2014 and 2015, and analysed using enzyme-linked immunosorbent assays to detect antibodies to the five pathogens. Results and discussion: This is the first description of seroprevalence of FMD and BT among small ruminants in Tanzania. Risk factor analysis identified sex (female) (OR for 2014: PPR: 2.49, CCPP: 3.11, FMD: 2.98, BT: 12.4, OR for 2015: PPR: 14.1, CCPP: 1.10, FMD: 2.67, BT: 1.90, BVD: 4.73) and increasing age (>2 years) (OR for 2014: PPR: 14.9, CCPP: 2.34, FMD: 7.52, BT: 126, OR for 2015: PPR: 8.13, CCPP: 1.11, FMD: 2.98, BT: 7.83, BVD: 4.74) as risk factors for exposure to these diseases.

show abstract

“…Serological tests performed in the reviewed studies were mostly ELISA techniques such as the competitive PPRV specific anti-H monoclonal based ELISA (c-ELISA) as recommended by the OIE (27,28,39,43,(48)(49)(50). The c-ELISA detects antibodies to confirm that the animal has been exposed to PPRV at some point in their lifetime.…”

Section: Diagnosismentioning

confidence: 99%

A Review of the Current Status of Peste des Petits Ruminants Epidemiology in Small Ruminants in Tanzania

et al. 2020

View full text Add to dashboard Cite

Peste des petits ruminants (PPR) is a highly contagious viral disease of sheep and goats with high mortality. The disease is of considerable economic importance in countries such as Tanzania, where small ruminant products are important for sustainable livelihoods. This review assesses current knowledge regarding the epidemiology of PPRV in Tanzania, highlighting the challenges with respect to control and suggesting possible interventions. Thirty-three articles were identified after literature searches using Google Scholar and PubMed. Studies revealed that PPRV is endemic in sheep and goats in Tanzania, although seropositivity has also been reported in cattle, camels, buffalo, Grant's gazelle, wildebeest and impala, but with no clinical manifestation. Three lineages (lineage II to IV) of PPRV have been identified in Tanzania, implying at least two separate introductions of the virus. Diagnosis of PPR in Tanzania is mostly by observation of clinical signs and lesions at post mortem. Risk factors in Tanzania include age, sex, species, and close contact of animals from different farms/localities. Although there is an efficacious vaccine available for PPR, poor disease surveillance, low vaccine coverage, and uncontrolled animal movements have been the bane of control efforts for PPR in Tanzania. There is need for collaborative efforts to develop interventions to control and eradicate the disease. The establishment of a national reference laboratory for PPR, conduct of surveillance, the development of high-quality DIVA vaccines, as well as execution of a carefully planned national vaccination campaign may be key to the control and subsequent eradication of PPR in Tanzania and achieving the global goal of eradicating PPR by 2030.

show abstract

Seroprevalence of Peste Des Petits Ruminants Virus from Samples Collected in Different Regions of Tanzania in 2013 and 2015

Cited by 10 publications

References 21 publications

Detection of peste des petits ruminants and concurrent secondary diseases in sheep and goats in Ngorongoro district, Tanzania

Detection of peste des petits ruminants and concurrent secondary diseases in sheep and goats in Ngorongoro district, Tanzania

Seroprevalence and risk factors for peste des petits ruminants and selected differential diagnosis in sheep and goats in Tanzania

A Review of the Current Status of Peste des Petits Ruminants Epidemiology in Small Ruminants in Tanzania

Contact Info

Product

Resources

About