Seroprevalence of cysticercosis in Bénin

Houinato, Dismand Stéphan; Ramanankandrasana, Bienvenue; Adjidé, Crespin; Melaku, Zenebe; Josse, R.; Avode, Gilbert; Dumas, Michel; Bouteille, Bernard

doi:10.1016/s0035-9203(98)90785-4

Cited by 24 publications

(24 citation statements)

References 7 publications

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“…This corresponded well with observations in large surveys held in other regions of West and Central Africa using antibody (Ab)‐ELISA and/or EITB, i.e. 1.3% seropositives in Benin (Houinato et al. 1998) and 2.4% in Togo (Dumas et al .…”

Section: Discussionsupporting

confidence: 89%

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A seroepidemiological study of human cysticercosis in West Cameroon

Nguekam

Zoli

Zogo

et al. 2003

Tropical Med Int Health

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SummaryWe studied the occurrence of human cysticercosis in 4993 individuals from three rural communities of Menoua Division, West Province of Cameroon. Circulating antigens of Taenia solium metacestodes were detected in 0.4%, 1.0% and 3.0% of the serum samples taken in Bafou, Bamendou and Fonakekeu, respectively, and examined using a monoclonal antibody-based enzyme-linked immunosorbent assay. This test detects only carriers of living cysticerci and gives thus a good idea of the presence of active cysticercosis. The percentage of persons infected with cysticercosis increased with age. Twenty-two of the 34 seropositives underwent computed tomography (CT) of the brain. Thirteen of them were CT-scan positive, which shows that neurocysticercosis was present in 59.1% of the tested seropositive persons. No living cysticerci were detected among 20 seronegative people. About 20.6% of the seropositives had a history of or current taeniasis against only 1.9% of the seronegatives. Based on these figures and on the data on porcine cysticercosis (prevalence: 11%) and human taeniasis (prevalence: 0.13%) collected in the same region, we conclude that T. solium cysticercosis is an endemic, but overlooked public health problem in West Cameroon.

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Section: Discussionsupporting

confidence: 89%

“…The observation that the occurrence of cysticercosis increases with age is in agreement with many other studies in Africa and elsewhere (Sarti et al . 1992; Houinato et al . 1998).…”

Section: Discussionmentioning

confidence: 99%

A seroepidemiological study of human cysticercosis in West Cameroon

Nguekam

Zoli

Zogo

et al. 2003

Tropical Med Int Health

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“…The seroprevalence detected by Ag-ELISA alone (7.7%) which is also equal to that detected by EITB is higher than the 3% reported in the West province of Cameroon (Nguekam et al, 2003), 1.3% in Benin (Houinato et al, 1998), and 2.4% in Togo (Dumas et al, 1989), which are all cysticercosis endemic regions or countries. It is similar to the 7% reported by Vanderick and Mbonyingabo (1972) based on autopsy findings in Rwanda in 1972 which was a hyperendemic country at that time.…”

Section: Discussionmentioning

confidence: 71%

“…reviewed the situation and found that large-scale surveys for human cysticercosis were only carried out in Togo (Houinato et al, 1998) and Benin (Dumas et al, 1989) with a seroprevalence of 2.4 and 1.3%, respectively. Based on the currently available information the prevalence of Taenia solium cysticercosis both in man and pigs in West Africa is generally much lower than in Eastern and Southern Africa .…”

Section: Introductionmentioning

confidence: 99%

Old focus of cysticercosis in a senegalese village revisited after half a century

et al. 2011

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The objective of this epidemiological study was to determine whether cysticercosis and especially neurocysticercosis is endemic in Soutou village about half a century after the 1962 outbreak. This study was carried out from September 2009 to February 2010. It involved a questionnaire administration, serology, treatment, coproscopy and neuro-imaging. Four hundred and three serum samples were collected from the village people, which covered 94% of the village population. By using a parallel combination of the antigen-detection ELISA and the enzyme-linked immunoelectrotransfer blot (EITB) a cysticercosis sero-prevalence of 11.9% (95% CI: 8.9-15.4%) was found. Cerebral CT-scans showed that 23.3% (10/43) of the seropositives were affected by neurocysticercosis. Four out of these 43 (9.3%) were tapeworm carriers. Seropositivity was significantly associated to older age groups (41-60 years old; p = 0.001 and 61-91 years old; p = 0.028) and absence of a household toilet (p = 0.001). It can be concluded that Soutou village is an active focus of Taenia solium cysticercosis about 50 years after the first reported epidemic outbreak.

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“…The OD values ‡0.400 were considered to be positive. This method has a sensitivity of 86% and a specificity of 92% (Houinato et al 1998).…”

Section: Antibody Detecting Elisa (Ab-elisa)mentioning

confidence: 99%

Combined use of an antigen and antibody detection enzyme‐linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi

Prado-Jean

Kanobana

Druet‐Cabanac

et al. 2007

Tropical Med Int Health

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Summaryobjective To evaluate the benefits of the detection of both circulating antibodies (Ab) and antigens (Ag) for the diagnosis of cysticercosis in people with epilepsy. Neurocysticercosis is a cause of neurological diseases world-wide, especially epilepsy. The clinical symptoms of neurocysticercosis are non-specific and diagnosis is often difficult.methods Serum samples were collected from subjects in a matched case-control study for epilepsy in the Kiremba area, Burundi, between March and April 2001 (epileptic cases ¼ 303; controls without epilepsy ¼ 606). The enzyme-linked immunosorbent assay (ELISA) was used for the detection of antibodies (Ab-ELISA) and circulating Ag (Ag-ELISA).results The Ab-ELISA revealed 58.7% positivity in epilepsy cases and 31.4% in healthy controls; and Ag-ELISA revealed 38.3% positivity in epilepsy cases and 20.0% in controls. The matched odds ratios were 3.6 (95%CI: 2.5-4.9) for Ab-ELISA, and 2.9 (95%CI: 2.1-4.3) for Ag-ELISA.conclusion Both Ag-and Ab-ELISA detected a significantly higher number of seropositives among people with epilepsy than among controls. The risk of epilepsy was high in cases with a positive Ag-ELISA, although less important than in cases with positivity for Ab-ELISA. Dead or degenerating cysticerci appear to be more frequently associated with epilepsy than living cysts. The high number of people with circulating Ag of Taenia solium suggests that the study area is a focus of active transmission of the parasite.

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Seroprevalence of cysticercosis in Bénin

Cited by 24 publications

References 7 publications

A seroepidemiological study of human cysticercosis in West Cameroon

A seroepidemiological study of human cysticercosis in West Cameroon

Old focus of cysticercosis in a senegalese village revisited after half a century

Combined use of an antigen and antibody detection enzyme‐linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi

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