Combined use of an antigen and antibody detection enzyme‐linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi

Prado-Jean, Annie; Kanobana, Kirezi; Druet‐Cabanac, Michel; Nsengyiumva, G.; Dorny, Pierre; Preux, Pierre‐Marie; Geerts, S.

doi:10.1111/j.1365-3156.2007.01860.x

Cited by 24 publications

(22 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Results for the same survey were found in several publications: It is the case for the survey of Nsengiyumva et al. (2003) whose data were completed in Prado‐Jean et al. (2007).…”

Section: Resultsmentioning

confidence: 52%

Meta‐analysis of the association between cysticercosis and epilepsy in Africa

et al. 2010

View full text Add to dashboard Cite

Summary Purpose: The association between cysticercosis and epilepsy has been widely studied in Latin America and Asia and has proven to be one of the main causes of epilepsy. Despite high prevalences of both diseases in Africa, their association remains unclear. In this article we quantified the strength of the association between epilepsy and cysticercosis in Africa and we proposed some guidelines for future studies. Methods: We performed a systematic review of literature on cysticercosis (considered as exposure) and epilepsy (considered as the disease) and collected data from both cross‐sectional and case–control studies. A common odds ratio was estimated using a random‐effects meta‐analysis model of aggregate published data. Results: Among 21 retrieved documents, 11 studies located in 8 African countries were included in the meta‐analysis. Odds ratio of developing epilepsy when presenting cysticercosis (defined as Taenia solium seropositivity) ranged from 1.3–6.1. Overall, association between cysticercosis and epilepsy was found significant with a common odds ratio of 3.4 [95% confidence interval (CI) 2.7–4.3; p < 0.001]. Discussion: The variability of the association found between the studies could be due to differences in study design or in pathogenesis of cysticercosis. Further studies should overcome identified problems by following some guidelines to improve epidemiologic and clinical assessment of the association. Better understanding of the relation between cysticercosis and epilepsy is a key issue in improving prevention of epilepsy in Africa.

show abstract

“…Results for the same survey were found in several publications: It is the case for the survey of Nsengiyumva et al. (2003) whose data were completed in Prado‐Jean et al. (2007).…”

Section: Resultsmentioning

confidence: 52%

Meta‐analysis of the association between cysticercosis and epilepsy in Africa

et al. 2010

View full text Add to dashboard Cite

show abstract

“…The Ag-ELISA is reported to have a sensitivity of 94.4% and a specificity of 97.6% (Erhart et al, 2002;Prado-Jean et al, 2007) whilst the EITB has a sensitivity of 98% and a specificity of 100% according to Tsang et al (1989). However, since serological tests are not the gold standard for detecting cysticercosis, this overall seropositivity might be overestimated by the detection of transient antibodies (Garcia et al, 2001) or underestimated because of the presence of false negatives.…”

Section: Discussionmentioning

confidence: 97%

Old focus of cysticercosis in a senegalese village revisited after half a century

et al. 2011

View full text Add to dashboard Cite

The objective of this epidemiological study was to determine whether cysticercosis and especially neurocysticercosis is endemic in Soutou village about half a century after the 1962 outbreak. This study was carried out from September 2009 to February 2010. It involved a questionnaire administration, serology, treatment, coproscopy and neuro-imaging. Four hundred and three serum samples were collected from the village people, which covered 94% of the village population. By using a parallel combination of the antigen-detection ELISA and the enzyme-linked immunoelectrotransfer blot (EITB) a cysticercosis sero-prevalence of 11.9% (95% CI: 8.9-15.4%) was found. Cerebral CT-scans showed that 23.3% (10/43) of the seropositives were affected by neurocysticercosis. Four out of these 43 (9.3%) were tapeworm carriers. Seropositivity was significantly associated to older age groups (41-60 years old; p = 0.001 and 61-91 years old; p = 0.028) and absence of a household toilet (p = 0.001). It can be concluded that Soutou village is an active focus of Taenia solium cysticercosis about 50 years after the first reported epidemic outbreak.

show abstract

“…Since the geographical distribution of T. solium remains to be fully elucidated in most African countries, the risk of adverse effects could be significantly underestimated. Several studies in Africa have confirmed the presence of human cysticercosis and specifically NCC in areas where schistosomiasis is endemic [36, 38–41]. Although NCC is considered more common in adults [42], children are also infected and in South Africa children down to the age of three have been found to suffer from NCC [43].…”

Section: Discussionmentioning

confidence: 99%

Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa

et al. 2015

View full text Add to dashboard Cite

BackgroundThis study aimed to map the distribution of Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa. These two major neglected tropical diseases are presumed to be widely distributed in Africa, but currently the level of co-distribution is unclear.MethodsA literature search on T. solium taeniosis/cysticercosis was performed to compile all known studies on the presence of T. solium and apparent prevalence of taeniosis and porcine cysticercosis in Africa. Studies were geo-referenced using an online gazetteer. A Bayesian framework was used to combine the epidemiological data on the apparent prevalence with external information on test characteristics to estimate informed district-level prevalence of taeniosis and porcine cysticercosis. Districts with T. solium taeniosis/cysticercosis presence were cross-referenced with the Global Neglected Tropical Diseases Database for schistosomiasis presence.ResultsThe search strategies identified 141 reports of T. solium in Africa from 1985 to 2014 from a total of 476 districts in 29 countries, 20 with porcine cysticercosis, 22 with human cysticercosis, and 16 with taeniosis, in addition to 2 countries identified from OIE reports. All 31 countries were considered, on national scale, to have co-distribution with schistosomiasis. Presence of both parasites was confirmed in 124 districts in 17 countries. The informed prevalence of taeniosis and porcine cysticercosis were estimated for 14 and 41 districts in 10 and 13 countries, respectively.ConclusionsWith the paucity of data, T. solium infection is grossly under-reported and expected to be more widespread than this study suggests. In areas where co-distribution occurs there is a need for increased emphasis on evaluation of integrated intervention approaches for these two helminth infections and allocation of resources for evaluating the extent of adverse effects caused by mass drug administration.Electronic supplementary materialThe online version of this article (doi:10.1186/s13071-015-0938-7) contains supplementary material, which is available to authorized users.

show abstract

Combined use of an antigen and antibody detection enzyme‐linked immunosorbent assay for cysticercosis as tools in an epidemiological study of epilepsy in Burundi

Cited by 24 publications

References 32 publications

Meta‐analysis of the association between cysticercosis and epilepsy in Africa

Meta‐analysis of the association between cysticercosis and epilepsy in Africa

Old focus of cysticercosis in a senegalese village revisited after half a century

Taenia solium taeniosis/cysticercosis and the co-distribution with schistosomiasis in Africa

Contact Info

Product

Resources

About