Seropositivity for helicobacter pylori antibodies is associated with lower occurrence of venous bypass graft occlusion

Limnell, Vilho; Pasternack, Rafael; Karjalainen, Jussi; Virtanen, Vesa; Lehtimäki, Terho; Aittoniemi, Janne

doi:10.1080/00365540410016753

Cited by 5 publications

(4 citation statements)

References 11 publications

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“…An inverse correlation with the occurrence of venous bypass graft occlusion after coronary artery bypass surgery was reported [19]: caution is needed in the interpretation of this finding because of the low number of patients studied and the very high rate of infection in patients without occlusion (82%).…”

Section: Extragastric Diseasesmentioning

confidence: 98%

Helicobacter pylori and Extragastric Diseases – Other Helicobacters

Nilsson

Pietroiusti

Gabrielli³

et al. 2005

Helicobacter

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The involvement of Helicobacter pylori in the pathogenesis of extragastric diseases continues to be an interesting topic in the field of Helicobacter-related pathology. Although conflicting findings have been reported for most of the disorders, a role of H. pylori seems to be important especially for the development of cardiovascular and hematologic disorders. Previously isolated human and animal Helicobacter sp. flexispira and "Helicobacter heilmannii" strains have been validated using polyphasic taxonomy. A novel enterohepatic Helicobacter has been isolated from mastomys and mice, adding to the list of helicobacters that colonize the liver. Genetic targets that may aid the classification of novel Helicobacter species have emerged. Animal models of Helicobacter-induced gastric and hepatobiliary diseases have offered insights to the mechanisms associated with premalignant transformation.

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Section: Extragastric Diseasesmentioning

confidence: 98%

Helicobacter pylori and Extragastric Diseases – Other Helicobacters

Nilsson

Pietroiusti

Gabrielli³

et al. 2005

Helicobacter

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“…This lack of association between H. pylori infection and IHD has also been suggested in a study by Schiele et al., who did not find a high risk for restenosis after percutaneous transluminal coronary angioplasty (PTCA), in H. pylori ‐infected patients [59]. Moreover, H. pylori seropositivity has been associated with a lower occurrence of venous bypass graft occlusion in patients with IHD who had undergone bypass surgery, since the rate of seropositivity in the occlusion‐free group was higher than in the group with occlusion ( p = .004) [60].…”

Section: Epidemiologic Evidencementioning

confidence: 99%

A Review of the Postulated Mechanisms Concerning the Association of Helicobacter pylori with Ischemic Heart Disease

2007

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Since its discovery, Helicobacter pylori has been implicated in the pathogenesis of several diseases, both digestive and extradigestive. Interestingly, the majority of the extradigestive-related literature is focused on two vascular manifestations: stroke and ischemic heart disease. Potential mechanisms for the establishment of a H. pylori-induced ischemic heart disease have been proposed with regard to chronic inflammation, molecular mimicry, oxidative modifications, endothelial dysfunction, direct effect of the microorganism on atherosclerotic plaques as well as changes regarding traditional or novel risk factors for ischemic heart disease or even platelet-H. pylori interactions. A positive link between H. pylori infection and ischemic heart disease has been suggested by a series of studies focusing on epidemiologic evidence, dyslipidemic alterations, upregulation of inflammatory markers or homocysteine levels, induction of hypercoagulability, oxidation of low-density lipoprotein, causation of impaired endothelial function, detection of H. pylori DNA in atherosclerotic plaques, and participation of certain antigens and antibodies in a cross-reactivity model. There are studies, however, which investigated the relationship between H. pylori and ischemic heart disease with regard to the same parameters and failed to confirm the suggested positive association. Further studies in the direction of interaction between H. pylori and the host's genotype as well as a quest for evidence towards novel risk factors for ischemic heart disease such as oxidative stress, vascular remodeling, vascular calcification, or vasomotor activity, may reveal a field of great interest, thus contributing to the determination of new potential mechanisms.

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“…Although multiple studies demonstrated a role for CMV in IH, a possible contribution of CMV in venous bypass failure received only limited attention so far and results have been inconclusive hitherto [6][7][8][9] . Therefore, we decided to elucidate the role of CMV on vein graft IH in an experimental animal model.…”

Section: Fk778 Attenuates Cytomegalovirusenhanced Vein Graft Intimal mentioning

confidence: 99%

FK778 Attenuates Cytomegalovirus-Enhanced Vein Graft Intimal Hyperplasia in a Rat Model

Kloppenburg

Graaf²,

Grauls³

et al. 2009

Intervirology

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Background: Venous grafts are commonly used to treat drug-resistant coronary artery disease, although long-term functionality is limited because of proliferation and migration of smooth muscle cells (SMC). As proliferating SMC are particularly susceptible for the stimulating effects of cytomegalovirus (CMV), we hypothesized that CMV infection may enhance cell proliferation and graft failure. Furthermore, we evaluated the potential of FK778 to prevent intimal hyperplasia. Apart from its antiviral properties, FK778 is a new immunosuppressive agent which may also affect SMC proliferation, making it an interesting drug to prevent (CMV-enhanced) venous graft intimal hyperplasia. Methods: Epigastric vein-to-common femoral artery interposition grafts were placed in four groups of 10 rats each. Rats received either FK778 (oral treatment, 15 mg/kg), were infected with CMV (1.25 × 10⁶ plaque-forming units) or were both treated and infected. Results: CMV infection resulted in a significant increase in intimal and medial cross-sectional area and medial wall thickness of the vein grafts. This effect was diminished by administration of FK778. Moreover, FK778 treatment alone resulted in a significant decrease in neointimal area and percentage of stenosis versus the control group. Conclusions: These data suggest a role of CMV in venous graft failure. Also, our results suggest a prospective role for the new immunosuppressive drug FK778 in the prevention of (CMV-mediated) vein graft intimal hyperplasia.

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Seropositivity for helicobacter pylori antibodies is associated with lower occurrence of venous bypass graft occlusion

Cited by 5 publications

References 11 publications

Helicobacter pylori and Extragastric Diseases – Other Helicobacters

Helicobacter pylori and Extragastric Diseases – Other Helicobacters

A Review of the Postulated Mechanisms Concerning the Association of Helicobacter pylori with Ischemic Heart Disease

FK778 Attenuates Cytomegalovirus-Enhanced Vein Graft Intimal Hyperplasia in a Rat Model

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