Helicobacter pylori and Extragastric Diseases – Other Helicobacters

Abstract

The involvement of Helicobacter pylori in the pathogenesis of extragastric diseases continues to be an interesting topic in the field of Helicobacter-related pathology. Although conflicting findings have been reported for most of the disorders, a role of H. pylori seems to be important especially for the development of cardiovascular and hematologic disorders. Previously isolated human and animal Helicobacter sp. flexispira and "Helicobacter heilmannii" strains have been validated using polyphasic taxonomy. A novel enterohepatic Helicobacter has been isolated from mastomys and mice, adding to the list of helicobacters that colonize the liver. Genetic targets that may aid the classification of novel Helicobacter species have emerged. Animal models of Helicobacter-induced gastric and hepatobiliary diseases have offered insights to the mechanisms associated with premalignant transformation.

Helicobacter pylori: immunoproteomics related to different pathologies

“…Unfortunately, it is unclear how a localized infection may affect areas remote from the site of primary infection and the demonstration of a casual relationship is rather difficult, since the etiology of most of the disorders in which the microorganism might be involved is multifactorial, H. pylori being, at most, one of the causative factors. Furthermore, the bacterium may be indirectly involved and the results of eradication therapy are interpreted with great difficulty [13].…”

Identification of Helicobacter species by 16S rDNA PCR and sequence analysis in human liver samples from patients with various etiologies of benign liver diseases

“…Recently, a new aspect of H. pylori-associated carcinogenesis was being discussed, the role of H. pylori in hepatocarcinogenesis [4]. Several reports indicated an increased prevalence of H. pylori in HCC tissue samples and livers infected with hepatitis viruses [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24] or in patients with primary biliary cirrhosis and primary sclerosing cholangitis [25,26]. Other studies, however, also show controversial results [27].…”

Adherence, Internalization, and Persistence of Helicobacter pylori in Hepatocytes

“…in hepatobiliary diseases in animals and humans [1][2][3][4]. Helicobacter DNA, or cross-reacting DNA, has been detected in hepatic tissues from both adults and children with and without liver disease [5][6][7][8][9][10][11][12].…”