Serologically defined specificities of the pig main histocompatibility complex (SL‐A)

Abstract

Six antigens detectable by the complement-dependent lymphocytotoxic techniqus were determined in pigs by six groups of alloimmune sera. It was confirmed that these specificities are controlled by the main histocompatibility region (SL-A). Serological and genetic studies showed that the given specificities (provisionaIly designated L1 to L6) form at least 6 haplotypes. In addition, family studies confirmed the linkage between SL-A region and C blood group locus. Maximum lod score values are in recombination fraction 6 = 0.2.

Detection of a new non‐MHC alloantigenic system (SLD) in pigs

“…SLA antigens in the Czech pigs were detected by 14 groups of cytotoxic sera determining antigens known under the laboratory numbers Ll-Ll4 (Hruban et al 1977). SLA antigens in the Danish pigs were detected by 37 French and 28 Danish antisera detecting 23 different antigenic specificities (Kristensen et al, 1985).…”

The presence of blood group and lymphocyte antigens on porcine granulocytes

“…The antigens provisionally designated Ll-L6 (Hruban et al, 1977) and L7-L10 (not published), which are controlled by a single chromosomal region were determined by cytotoxic sera (each antigen by at least two sera). The locus controlling antigens Ll-LlO is identical with the SLA region described by Vaiman et al (1970), as transplantation experiments confirmed (Hruban et al, 1974;Pazdera et al, 1980) and the first international serum comparison indicated (Dr M. Vaiman, Jouy-en-Josas, France).…”