Serological Relationship of Swine Vesicular Disease Virus and Coxsackie B5 Virus

Jh, Graves

doi:10.1038/245314a0

Cited by 99 publications

(59 citation statements)

References 3 publications

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“…These viruses can cause clinically indistinguishable diseases in swine; however, FMDV has a much broader host-range and is responsible for one of the most economically important diseases of farm animals. SVDV is closely related both antigenically and genetically to coxsackie virus B5 (Graves, 1973;Inoue et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Dynamics of picornavirus RNA replication within infected cells

Belsham

Normann

2008

Journal of General Virology

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Replication of many picornaviruses is inhibited by low concentrations of guanidine. Guanidine-resistant mutants are readily isolated and the mutations map to the coding region for the 2C protein. Using in vitro replication assays it has been determined previously that guanidine blocks the initiation of negative-strand synthesis. We have now examined the dynamics of RNA replication, measured by quantitative RT-PCR, within cells infected with either swine vesicular disease virus (an enterovirus) or foot-and-mouth disease virus as regulated by the presence or absence of guanidine. Following the removal of guanidine from the infected cells, RNA replication occurs after a significant lag phase. This restoration of RNA synthesis requires de novo protein synthesis. Viral RNA can be maintained for at least 72 h within cells in the absence of apparent replication but guanidine-resistant virus can become predominant. Amino acid substitutions within the 2C protein that confer guanidine resistance to swine vesicular disease virus and foot-and-mouth disease virus have been identified. Even when RNA synthesis is well established, the addition of guanidine has a major impact on the level of RNA replication. Thus, the guanidine-sensitive step in RNA synthesis is important throughout the virus life cycle in cells.

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Section: Introductionmentioning

confidence: 99%

Dynamics of picornavirus RNA replication within infected cells

Belsham

Normann

2008

Journal of General Virology

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“…The causative agent, SVD virus (SVDV) belongs to the enterovirus genus, of the Picornaviridae family and has a close serological relationship to coxsackievirus B5 (Graves, 1973). Like other picornaviruses, the genome of SVDV is a single-stranded RNA with a positive polarity.…”

Section: Production Of Infectious Swine Vesicular Disease Virus From mentioning

confidence: 99%

Production of Infectious Swine Vesicular Disease Virus from Cloned cDNA in Mammalian Cells

Inoue

Yamaguchi²,

Saeki³

et al. 1990

Journal of General Virology

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“…It even was suggested that SVDV was a swine-adapted Coxsackie B5 isolate (22). Sequence data show that SVDV has approximately 75 -85 % nucleotide homology with Coxsackie B5 virus (31), and phylogenetic analysis shows that SVD and Coxsackie B5 probably shared a common ancestor in the period between 1945 and 1965 (50).…”

mentioning

confidence: 99%

“…Because of this host tropism and antigenic similarities, SVDV is thought to be related to Coxsackie B5 virus (4,22). It even was suggested that SVDV was a swine-adapted Coxsackie B5 isolate (22).…”

mentioning

confidence: 99%