Serological Evidence in Relation to the Time of Initial Immunization of the Rhesus Negative Mother

Feto-maternal haemorrhage in therapeutic abortion

“…With the staining method introduced by Kleihauer, Braun, and Betke (1957) it was shown that appreciable transplacental haemorrhage could occur during the third stage of labour (Zipursky, Hull, White, and Israels, 1959 ;Finn et al, 1961). Krieger (1966), in a study on the appearance of antibodies in the maternal serum, produced evidence that transplacental bleeding could also occur during the antepartum phase. Zipursky, Pollock, Chown, and Israels (1963) found that haemorrhage resulted also from operative procedures which damaged the placental site.…”

On Rh Immunization and Its Prevention: Observations and Thoughts

“…On the six who had antibodies at delivery. What we know about these women is shown in table 11. From these data we conclude that the antibodies were primary-response antibodies, presumably pure IgM [4] except in No.…”

Rapid Clearance of Rh Positive Rlood During Experimental Rh Immunisation

“…Recently it has been claimed that by using very sensitive tech niques it is possible to detect the presence of anti-D at an earlier stage of the process of immunisation than is usually found. Thus Krieger [1966] found anti-D to be detectable in 65 mothers out of 903 mothers tested eight days after delivery, antibody having been undetectable at delivery. It was, however, not stated how many of these were primiparae and this is an important consideration because with Rh positive pregnancies after the first, there is always the possi bility that one is dealing with a secondary rather than a primary response.…”