Sero-negative polyarthritis. The Bedsonia (Chlamydia) group of agents and Reiter's disease. A progress report.

Dunlop, E. M. C.; Harper, Ian; Jones, B. R.

doi:10.1136/ard.27.3.234

Cited by 31 publications

(5 citation statements)

References 16 publications

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“…In the 1960s, Chlamydia (earlier Bedsonia) was suspected of being involved in the urethritis and conjunctivitis of patients with Reiter's disease, and slowly the association between urethritis, arthritis, and Chlamydia was established (5). In addition to Shigella and now Chlamydia, other infections, such as Salmonella (7), were observed to cause sterile arthritis.…”

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confidence: 98%

Reactive arthritis

Leirisalo‐Repo

2005

Scandinavian Journal of Rheumatology

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Reactive arthritis (ReA) was known as Reiter's disease or Fiessinger-Leroy disease for nearly 100 years. However, during the past 30 years the disease has been known as reactive arthritis, a member of the spondyloarthritis family. Despite knowing the initiating event (infection) and genetic constitution (many patients have HLA-B27) of ReA, a model of interplay between environment and genetics, its pathogenesis is still incompletely known. This review covers the epidemiology, clinical features, treatment, and prognosis of ReA.

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confidence: 98%

Reactive arthritis

Leirisalo‐Repo

2005

Scandinavian Journal of Rheumatology

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“…All of these observations suggest that an infectious agent, or antigens from it, in the joint, combined with host immune processes, are critical in the genesis of RS. While there have been reports of successful chlamydial culture from joint tissue (22)(23)(24), many investigators have been unable to reproduce these results (8,25); such failures have led to the conclusion that antigenic debris, but not intact organism, is involved in the reactive arthritis (2,3). However, clinical laboratory methods currently used to screen for chlamydia detect only phenotypic characteristics of the organism (infectivity, antigens) or host immune responses, and both of these can vary according to the biologic state of the organism, which may account in part for the low sensitivity of such methods (26).…”

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confidence: 99%

Molecular evidence for the presence of chlamydia in the synovium of patients with reiter's syndrome

Rahman

Cheema

Schumacher

et al. 1992

Arthritis & Rheumatism

129

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Objective. There is much evidence indicating that chlamydial antigens in the synovium may be critical in the pathogenesis of Reiter's syndrome (RS), but it is not known whether intact organisms are present in that tissue in any stage of the disease. The present study was undertaken to begin to address this question.Methods. We used a highly specific and sensitive molecular hybridization screening system which detects chlamydial RNA, to examine synovial biopsy samples from 22 patients with various arthropathies, including 9 with RS.Results. Seven of the 9 RS patients were positive for chlamydial RNA, while 3 of the 13 non-RS patients were also positive; positive results in the non-RS patients

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“…While the clinical association between certain venereal infections and arthritic syndromes is well established, the methods routinely used for detecting Neisseria, Chlamydia, and Ureaplasma have serious limitations. Microbiologic isolation of these organisms from synovial fluid is difficult, with a success rate of 25-50% for Neisseria (12)(13)(14)(15), and 0-50% for Chlamydia (16)(17)(18), with even lower success rates for Ureaplasma (19)(20)(21). Immunochemical detection, which has shown promise (22), also remains a research tool.…”

Section: Discussionmentioning

confidence: 99%

Molecular detection of bacterial DNA in venereal‐associated arthritis

Bulbul

Schumacher

et al. 1996

Arthritis & Rheumatism

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Objective. To evaluate the utility of polymerase chain reaction (PCR) amplification in detecting DNA from venereal-associated microorganisms in the synovial fluid of patients with inflammatory arthritis.Methods. Oligonucleotide primers were developed for nested PCR based on Chlamydia, Ureaplasma, and Neisseria DNA sequences. PCR products were detected by gel electrophoresis and dot-blot hybridization. Primers specific for the target bacterial DNA were used to search for bacterial DNA in 61 synovial fluid specimens from patients with inflammatory arthritis, including several clinically associated with venereal infection.Results. Five of the 61 synovial fluid specimens were positive for Neisseria gonorrhoeae DNA. Four of the 5 patients had clinical diagnoses of gonococcal arthritis; the other patient had an unexplained monarthritis. One specimen from a patient with a clinical diagnosis of gonococcal arthritis was negative for N gonorrhoeae.

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Sero-negative polyarthritis. The Bedsonia (Chlamydia) group of agents and Reiter's disease. A progress report.

Cited by 31 publications

References 16 publications

Reactive arthritis

Reactive arthritis

Molecular evidence for the presence of chlamydia in the synovium of patients with reiter's syndrome

Molecular detection of bacterial DNA in venereal‐associated arthritis

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