Reactive arthritis

Abstract

Reactive arthritis (ReA) was known as Reiter's disease or Fiessinger-Leroy disease for nearly 100 years. However, during the past 30 years the disease has been known as reactive arthritis, a member of the spondyloarthritis family. Despite knowing the initiating event (infection) and genetic constitution (many patients have HLA-B27) of ReA, a model of interplay between environment and genetics, its pathogenesis is still incompletely known. This review covers the epidemiology, clinical features, treatment, and prognosis of ReA.

High frequency of reactive arthritis in adults afterYersinia pseudotuberculosisO:1 outbreak caused by contaminated grated carrots: Table 1

“…In the present study, 67% of the nine HLA typed patients with ReA were HLA-B27 positive. The frequency was higher than that usually reported in the single-source outbreaks of ReA (30%–50%) 12. Does this mean that arthritogenity of Y pseudotuberculosis is low and it often needs HLA-B27 for ReA to be manifest?…”

Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study

“…The frequency of ReA found in these studies has ranged from 1–21% 18. Only a few population-based studies of ReA have been published,19 – 21 primarily in Scandinavian countries where the distribution of enteric pathogens and population genetics may differ significantly from those in the US.…”

Campylobacter Reactive Arthritis: A Systematic Review

“…Future studies are required to look at the health and economic impact of ReA, especially its chronic forms. Incidence of acute ReA following Camplobacter gastroenteritis Table 1 Infectious agents associated with the development of reactive arthritis (Modified from [71])…”