Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study

Townes, John M.; Deodhar, Atul; Laine, Ellen S; Smith, Kirk E.; Krug, Hollis E.; Barkhuizen, André; Thompson, Mollie E.; Cieslak, Paul R.; Sobel, Jeremy

doi:10.1136/ard.2007.083451

Cited by 130 publications

(91 citation statements)

References 30 publications

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“…In our study, 15 of the 21 patients with ReA were women (71%), which correspond to previous reports concerning enteropathogenic infections (14,15). ReA occurred in the latter study only in adults, the median age of patients being 60 years (15).…”

Section: Discussionsupporting

confidence: 89%

Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland

Uotila

Antonen

Laine

et al. 2011

Scandinavian Journal of Rheumatology

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Section: Discussionsupporting

confidence: 89%

Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland

Uotila

Antonen

Laine

et al. 2011

Scandinavian Journal of Rheumatology

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“…The remaining childhood HUS is either primary HUS caused by complement dysregulation, with an estimated prevalence of seven per one million children in Europe, or secondary HUS [4]. In adults, STEC infections may cause HUS, although it is more commonly associated with thrombotic thrombocytopenic purpura (TTP) [5]. The reservoir of the STEC is the intestinal tract of the domestic animals usually cows.…”

Section: Epidemiologymentioning

confidence: 99%

Hemolytic Uremic Syndrome Caused by Shiga Toxin-Producing Escherichia coli Infections: An Overview

Abdullah¹,

Al-Sultan

Jassim³

et al. 2014

Clon Transgen

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The purpose of this manuscript is to provide a current overview on the Shiga Toxin / verotoxin-producing Escherichia coli (STEC) hemolytic uremic syndrome (HUS) with emphasis on the epidemiology, clinical and laboratory manifestations, pathogenesis, recommended assessment, treatment strategies and prognosis. Hemolytic uremic syndrome (HUS) is a cause of the community-acquired acute renal insufficiency in young children. The outbreak in Germany illustrated both the emerging importance of non-O157 serotypes as agents of human disease and the potential for large-scale methods of food production and distribution to result in widespread disease. Children with STEC-induced HUS typically have a prodromal illness that can rapidly develop severe and multisystem life-threatening complications. STEC infection is acquired through contaminated food or water. Thrombotic microangiopathy is the mechanism of the development of the characteristic pathologic lesion of HUS. Any patient with a recent history of diarrhea and signs of a multi-organ disorder requires a proper assessment for the possible development of HUS. Appropriate laboratory testing for both O157 and non-O157 serotypes, as well as prompt initiation of infection control procedures for confirmed or suspected cases, will facilitate follow-up investigation to identify the source of disease and will help to prevent secondary transmission. Currently, diagnostic test to predict which patients will develop HUS is not available. Supportive care and intravenous fluid replacement are the cornerstones of treatment because of the current lack of safe and specific therapeutic intervention. Culizumab and/or plasma treatment may be considered in patients with severe CNS involvement who have a poor prognosis. None of the multiple therapeutic agents including antithrombotic agents, plasma exchange and/or plasma infusion, tissue-type plasminogen activator, and oral Shiga toxin-binding agent that have been used is recommended. For most patients with uncomplicated STEC-associated gastroenteritis who are treated with supportive care, the prognosis was excellent. Public health interventions are the key to prevent STEC-associated diarrhea and HUS. Researches will improve the care of patients with different HUS types in the years to come. The identification of genetic factors associated with HUS will contribute to a better insight of the pathogenesis of HUS and will have potential therapeutic and preventive implications.

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“…Common sites of heel involvement are at the insertions of the Achilles tendon and of the plantar fascia on the calcaneus, as seen in this patient. Estimates of the frequency of enthesitis in patients with reactive arthritis have ranged from 20 to 90 percent 1) . Dactylitis typically presents as sausage shaped digits, but the frequency in reactive arthritis has not been reported.…”

Section: Dr Steinʼs Commentmentioning

confidence: 99%

Dr. Stein’s Problem-Based Learning

Morita

Kano

Uehara

et al. 2016

Juntendo Medical Journal

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Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study

Abstract: This is the first population-based study of ReA following infections due to bacterial enteric pathogens in the USA. These data will help determine the burden of illness due to these pathogens and inform clinicians about potential sequelae of these infections.

Cited by 130 publications

References 30 publications

Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland

Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland

Hemolytic Uremic Syndrome Caused by Shiga Toxin-Producing Escherichia coli Infections: An Overview

Dr. Stein’s Problem-Based Learning

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Reactive arthritis following culture-confirmed infections with bacterial enteric pathogens in Minnesota and Oregon: a population-based study

Abstract: This is the first population-based study of ReA following infections due to bacterial enteric pathogens in the USA. These data will help determine the burden of illness due to these pathogens and inform clinicians about potential sequelae of these infections.

Cited by 130 publications

References 30 publications

Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland

Reactive arthritis in a population exposed to an extensive waterborne gastroenteritis outbreak after sewage contamination in Pirkanmaa, Finland

Hemolytic Uremic Syndrome Caused by Shiga Toxin-Producing Escherichia coli Infections: An Overview

Dr. Stein&rsquo;s Problem-Based Learning

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Product

Resources

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Dr. Stein’s Problem-Based Learning