Serial processing in primary and secondary somatosensory cortex: A DCM analysis of human fMRI data in response to innocuous and noxious electrical stimulation

Khoshnejad, Mina; Piché, Mathieu; Saleh, Soha; Duncan, Gary E.; Rainville, Pierre

doi:10.1016/j.neulet.2014.06.013

Cited by 29 publications

(28 citation statements)

References 30 publications

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“…Thus, significant activation of BA44 and BA45 might be driven by the recognition of action in the phantom. The control group showed strong SII activity during electrical stimulation, which is inline with an fMRI study by Khoshnejad, Piché, Saleh, Duncan, and Rainville (2014), also reporting SII activation in a group of healthy subjects during transcutaneous electrical stimulation. We did not find significant SI activation in the controls, which could be related to the electrical stimulation of different body sites which are both left and right lateralized (see Fig.…”

Section: Discussionsupporting

confidence: 88%

Neural correlates of evoked phantom limb sensations

Andoh

Diers

Milde

et al. 2017

Biological Psychology

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Section: Discussionsupporting

confidence: 88%

Neural correlates of evoked phantom limb sensations

Andoh

Diers

Milde

et al. 2017

Biological Psychology

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“…; Khoshnejad et al. ), in line with the present coherence results. However, the functional MRI data did not detect significant direct modulation between SI and SIIi.…”

Section: Discussionsupporting

confidence: 93%

Reduced functional connectivity of somatosensory network in writer's cramp patients

et al. 2016

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BackgroundThe involvement of motor cortex and sensorimotor integration in patients with writer's cramp (WC) has been well documented. However, the exact neurophysiological profile within the somatosensory system, including primary somatosensory cortex (SI), contralateral (SIIc), and ipsilateral (SIIi) secondary somatosensory areas remains less understood.MethodsThis study investigated the neuromagnetic cortical activities of median nerve stimulation in 10 patients with WC and 10 healthy controls (HC). To comprehensively explore all the aspects of somatosensory functioning, we analyzed our data with the minimum norm estimate (MNE), the time‐frequency approach with evoked and induced activities, and functional connectivity between SI and SIIc (SI–SIIc), SI and SIIi (SI–SIIi), and SIIc and SIIi (SIIc–SIIi) from theta to gamma oscillations.ResultsNo significant between‐group differences were found in the MNE cortical amplitudes of SI, SIIc, and SIIi. Power strengths of evoked gamma oscillation and induced beta synchronization were also equivalent between WC and HC groups. However, we found significantly reduced theta coherence of SI–SIIi, alpha coherence of SI–SIIi and SIIc–SIIi, as well as beta coherence of SIIc–SIIi in patients with WC.ConclusionOur results suggest the involvement of somatosensory abnormalities, primarily with the form of functional connectivity, in patients with WC.

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“…The current observation of a change in the processing mode may explain recent conflicting results from fMRI-DCM analyses (Liang et al, 2011; Kalberlah et al, 2013; Chung et al, 2014; Khoshnejad et al, 2014). The parallel processing of information should be found to be the prominent mode based on analyses that focus mainly on the perception of a change in the somatosensory environment, e.g., analyses based on data acquired shortly after stimulus onset or perhaps based on the use of only stimuli.…”

Section: Discussionmentioning

confidence: 70%

“…We used a DCM analysis to clarify whether somatosensory information is processed in parallel (directly entering the SII; Liang et al, 2011; Chung et al, 2014) or in series (entering only the SI and then further transmitted from the SI to the SII; Kalberlah et al, 2013; Khoshnejad et al, 2014). Specifically, we were interested in whether the processing route of somatosensory information changes over time.…”

Section: Methodsmentioning

confidence: 99%

“…However, these studies reached different conclusions regarding whether somatosensory information is processed in parallel or in series. Two of these studies reported evidence supporting parallel processing of somatosensory information (Liang et al, 2011; Chung et al, 2014), while the other two studies reported evidence supporting serial processing of somatosensory information (Kalberlah et al, 2013; Khoshnejad et al, 2014). A recent study that applied DCM analysis to magnetoencephalographic (MEG) data suggested that somatosensory data are processed in parallel during the early stage (within the first 100 ms; Klingner et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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The Processing of Somatosensory Information Shifts from an Early Parallel into a Serial Processing Mode: A Combined fMRI/MEG Study

Klingner

Brodoehl

Huonker

et al. 2016

Front. Syst. Neurosci.

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The question regarding whether somatosensory inputs are processed in parallel or in series has not been clearly answered. Several studies that have applied dynamic causal modeling (DCM) to fMRI data have arrived at seemingly divergent conclusions. However, these divergent results could be explained by the hypothesis that the processing route of somatosensory information changes with time. Specifically, we suggest that somatosensory stimuli are processed in parallel only during the early stage, whereas the processing is later dominated by serial processing. This hypothesis was revisited in the present study based on fMRI analyses of tactile stimuli and the application of DCM to magnetoencephalographic (MEG) data collected during sustained (260 ms) tactile stimulation. Bayesian model comparisons were used to infer the processing stream. We demonstrated that the favored processing stream changes over time. We found that the neural activity elicited in the first 100 ms following somatosensory stimuli is best explained by models that support a parallel processing route, whereas a serial processing route is subsequently favored. These results suggest that the secondary somatosensory area (SII) receives information regarding a new stimulus in parallel with the primary somatosensory area (SI), whereas later processing in the SII is dominated by the preprocessed input from the SI.

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Serial processing in primary and secondary somatosensory cortex: A DCM analysis of human fMRI data in response to innocuous and noxious electrical stimulation

Cited by 29 publications

References 30 publications

Neural correlates of evoked phantom limb sensations

Neural correlates of evoked phantom limb sensations

Reduced functional connectivity of somatosensory network in writer's cramp patients

The Processing of Somatosensory Information Shifts from an Early Parallel into a Serial Processing Mode: A Combined fMRI/MEG Study

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