Neural correlates of evoked phantom limb sensations

Andoh, Jamila; Diers, Martin; Milde, Christopher; Frobel, C.; Kleinböhl, Dieter; Flor, Herta

doi:10.1016/j.biopsycho.2017.04.009

Cited by 32 publications

(25 citation statements)

References 53 publications

(72 reference statements)

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“…In line with a previous study (Andoh et al., 2017), we could evoke phantom sensations and even PLP by nonpainful electrical stimulation at the residual limb in amputees with chronic PLP. PLP has been shown to be temporally reduced after blocking peripheral inputs by injecting lidocaine in amputees with PLP (Buch et al., 2019; Vaso et al., 2014).…”

Section: Discussionsupporting

confidence: 92%

Peripheral input and phantom limb pain: A somatosensory event‐related potential study

Liu

Andoh

Lyu

et al. 2020

European Journal of Pain

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Section: Discussionsupporting

confidence: 92%

Peripheral input and phantom limb pain: A somatosensory event‐related potential study

Liu

Andoh

Lyu

et al. 2020

European Journal of Pain

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“…As mentioned above, it was found that people who experience worse PLP also show a greater shift of their lower face representation towards the missing hand cortex ( Flor et al., 1995 ). A similar association was never established for non-painful phantom sensations, which have been in turn linked with frontal and parietal activity ( Andoh et al., 2017 ). The finding of a positive association between S1 remapping and PLP has been replicated using multiple paradigms and participant groups ( Diers et al., 2010 ; Lotze et al., 1999 ; MacIver et al., 2008 ).…”

Section: Altered Body Representation Following Arm Amputationmentioning

confidence: 56%

Brain (re)organisation following amputation: Implications for phantom limb pain

2020

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Following arm amputation the region that represented the missing hand in primary somatosensory cortex (S1) becomes deprived of its primary input, resulting in changed boundaries of the S1 body map. This remapping process has been termed ‘reorganisation’ and has been attributed to multiple mechanisms, including increased expression of previously masked inputs. In a maladaptive plasticity model, such reorganisation has been associated with phantom limb pain (PLP). Brain activity associated with phantom hand movements is also correlated with PLP, suggesting that preserved limb functional representation may serve as a complementary process. Here we review some of the most recent evidence for the potential drivers and consequences of brain (re)organisation following amputation, based on human neuroimaging. We emphasise other perceptual and behavioural factors consequential to arm amputation, such as non-painful phantom sensations, perceived limb ownership, intact hand compensatory behaviour or prosthesis use, which have also been related to both cortical changes and PLP. We also discuss new findings based on interventions designed to alter the brain representation of the phantom limb, including augmented/virtual reality applications and brain computer interfaces. These studies point to a close interaction of sensory changes and alterations in brain regions involved in body representation, pain processing and motor control. Finally, we review recent evidence based on methodological advances such as high field neuroimaging and multivariate techniques that provide new opportunities to interrogate somatosensory representations in the missing hand cortical territory. Collectively, this research highlights the need to consider potential contributions of additional brain mechanisms, beyond S1 remapping, and the dynamic interplay of contextual factors with brain changes for understanding and alleviating PLP.

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“…The co-occurrence of these post-amputation sensations suggest that they may share neural mechanisms with PLP [ 48 ]. An fMRI study by Andoh et al showed that inducing non-painful phantom sensations in people with amputations activated the somatosensory and premotor cortices contralateral to the amputated limb [ 69 ]. The activation of similar cortical areas has been recorded in patients with PLP upon induction of their PLP [ 70 – 74 ].…”

Section: Discussionmentioning

confidence: 99%

The prevalence and risk factors for phantom limb pain in people with amputations: A systematic review and meta-analysis

et al. 2020

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Background Phantom limb pain (PLP)-pain felt in the amputated limb-is often accompanied by significant suffering. Estimates of the burden of PLP have provided conflicting data. To obtain a robust estimate of the burden of PLP, we gathered and critically appraised the literature on the prevalence and risk factors associated with PLP in people with limb amputations. Methods Articles published between 1980 and July 2019 were identified through a systematic search of the following electronic databases:

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Neural correlates of evoked phantom limb sensations

Cited by 32 publications

References 53 publications

Peripheral input and phantom limb pain: A somatosensory event‐related potential study

Peripheral input and phantom limb pain: A somatosensory event‐related potential study

Brain (re)organisation following amputation: Implications for phantom limb pain

The prevalence and risk factors for phantom limb pain in people with amputations: A systematic review and meta-analysis

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