Serial measurement of Wisteria floribunda agglutinin positive Mac-2-binding protein is useful for predicting liver fibrosis and the development of hepatocellular carcinoma in chronic hepatitis C patients treated with IFN-based and IFN-free therapy

Abstract

Real-time monitoring of the serum M2BPGi level after antiviral therapy for CHC patients could be a helpful screening tool for assessing the risk of HCC. M2BP and its glycan structure could be associated together with hepatocarcinogenesis.

Improvement of liver stiffness in patients with hepatitis C virus infection who received direct‐acting antiviral therapy and achieved sustained virological response

“…We also evaluated each parameter before treatment, at EOT, and at SVR24, whereas Miyaki et al assessed parameters only before and after treatment. Further, we analyzed sequential liver stiffness levels while considering the influence of necroinflammatory activity, because liver fibrosis markers such as mac‐2‐binding protein have also been shown to be affected both by degree of liver fibrosis and by necroinflammatory activity . Specifically, we evaluated liver stiffness in patients with ALT levels ≤ 30, which correspond to low necroinflammatory activity in the liver.…”

Association of Mac‐2‐binding protein glycosylation isomer level with nutritional status in chronic liver disease

“…In our study, the median M2BPGi level in the HBV group was 0.75 ± 0.86 COI, which was lower than that in the HCV (1.32 ± 3.72 COI) and NBNC hepatitis groups (1.55 ± 3.41 COI). Third, as reported previously, M2BPGi levels tend to increase in patients with hepatic inflammation . Therefore, the administration of nucleos(t)ide analogues in 61.2% (41/67) of patients lowered M2BPGi levels in the HBV group.…”

“…These trends may result from the fact that both M2BPGi levels and nutritional status markers correlated strongly with the change in Child–Pugh class (as shown in Figs ). In addition, as mentioned earlier, M2BPGi levels tend to increase in patients with hepatic inflammation . Therefore, when examined in a single Child–Pugh class, the presence or absence of inflammation may affect the reduced correlation between M2BPGi levels and nutritional status markers.…”

“…b). According to the previous report, serum M2BPGi levels in patients with HCC are significantly higher than those in patients without HCC . In fact, in the present study, median M2BPGi levels in patients with HCC and without HCC were 2.10 ± 4.16 and 1.00 ± 3.02, respectively.…”

Clinical Evaluation of Hepatocarcinogenesis and Outcome Using a Novel Glycobiomarker <i>Wisteria floribunda</i> Agglutinin-Positive Mac-2 Binding Protein (WFA⁺-M2BP) in Chronic Hepatitis C with Advanced Fibrosis

“…An automatic and high-throughput assay can measure WFA + -M2BP levels in 10-μL serum samples (8). The WFA + -M2BP level in CHC patients was found to increase with the progression of liver fibrosis (10) and was found to be a predictor of HCC (11). Hence, predicting the development of HCC and the outcomes in high-risk patients, such as those with advanced fibrosis, is important.…”