Serial dual single-photon emission computed tomography of thallium-201 and iodine-123 beta-methyliodophenyl pentadecanoic acid scintigraphy can predict functional recovery of patients with coronary artery disease after coronary artery bypass graft surgery

Fujita, K; Kasama, Shu; Kurabayashi, Masahiko

doi:10.1097/mnm.0000000000000228

Cited by 3 publications

(3 citation statements)

References 24 publications

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“…Some reports supported our findings that a low mismatch score was associated with poor prognosis. Patients with ischemic heart disease who had a low mismatch scores tended to have worse prognoses compared to those with high mismatch scores after recanalization . Existence of metabolically impaired but viable myocardium may result in high mismatch score and this predicted good prognosis.…”

Section: Discussionmentioning

confidence: 98%

A low perfusion‐metabolic mismatch in ^99mTl and ¹²³I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement

et al. 2019

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Aim:This study investigated the prognostic factors of cardiac death or cardiac failure using cardiac scintigraphy, echocardiography (UCG), and magnetic resonance imaging (MRI) in asymptomatic systemic sclerosis (SSc) patients. Methods:We retrospectively evaluated SSc patients who had undergone cardiac scintigraphy using 99m thallium ( 99m Tl) and 123 I-β-methyl-P-iodophenyl-pentadecanoic acid ( 123 I-BMIPP), UCG, and cardiac MRI. We calculated the mismatch score in scintigraphy by subtracting the uptake of 123 I-BMIPP from that of 99m Tl. Patients were divided into two groups according to whether they survived with no cardiac failure or subsequently proceeded to cardiac failure or death during the study period. We identified prognostic factors by analyzing 99m Tl and 123 I-BMIPP uptake, mismatch scores, UCG findings, and cardiac delayed enhancement on MRI. We also evaluated pathological evidence of myocardial fibrosis. Results:Of 33 SSc cases, 11 proceeded to cardiac failure or death. There was no significant difference in UCG or MRI findings between the two groups. Low mismatch score in cardiac scintigraphy was the only predictive factor of cardiac failure or death by multivariate analysis (odds ratio, 6.48; 95% confidence interval, 1.22-423.2; P = 0.01). When patients were grouped according to high or low mismatch scores based on a cut-off using receiver operating characteristics curve analysis, the cumulative incidence of cardiac failure or death was higher in the low mismatch group than in the high mismatch group (P = 0.02). The percentage of fibrosis was significantly higher in deceased cases compared to surviving cases. Conclusions:Low mismatch score in cardiac scintigraphy was associated with cardiac death or cardiac failure in SSc patients. K E Y W O R D S cardiac involvement, cardiac scintigraphy, systemic sclerosis | 1009 IIDA et Al.

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Section: Discussionmentioning

confidence: 98%

A low perfusion‐metabolic mismatch in ^99mTl and ¹²³I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement

et al. 2019

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“…Особый интерес представляет собой сцинтиграфия миокарда с изотопами таллия (199Tl или 201Tl), физи-ко-химические свойства которого близки к ионам калия [33]. Механизм аккумуляции данного изотопа в миокар-де обусловлен активным трансмембранным переносом с помощью Na/K-АТФ-зависимого насоса [33].…”

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“…Механизм аккумуляции данного изотопа в миокар-де обусловлен активным трансмембранным переносом с помощью Na/K-АТФ-зависимого насоса [33]. Поскольку включение таллия в миокард пропорционально кровото-ку, его используют для оценки состояния микроциркуля-ции сердечной мышцы.…”

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Predictors of Ventricular Tachyarrhythmias in Patients With Coronary Heart Disease and Implantable Cardioverter-Defibrillators

Atabekov¹,

Сазонова²,

Баталов³

et al. 2017

Sib. med. ž. (Tomsk)

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Научно-исследовательский институт кардиологии, Томский национальный исследовательский медицинский центр Российской академии наук, Томск, Российская Федерация Cardiology Research Institute, Tomsk National Research Medical Centre, Russian Academy of Sciences, Tomsk, Russian FederationДанная обзорная статья посвящена выявлению новых предикторов развития желудочковых тахиаритмий (ЖТА). Установка имплантируемого кардиовертера-дефибриллятора (ИКД) пациентам с факторами риска является одним из основных способов профилактики внезапной сердечной смерти (ВСС) в результате возникновения ЖТА. В то же время показано, что срабатывания данного устройства на протяжении 5 лет наблюдения регистрируются лишь у 15-25% больных. В связи с тем, что установка ИКД ассоциирована с госпитализацией и инфекционно-воспали-тельными осложнениями, существует необходимость совершенствования стратификации риска и поиска новых прогностических маркеров ВСС и ЖТА, для того чтобы уменьшить количество нерационально имплантированных кардиовертеров-дефибрилляторов и снизить необоснованные затраты на госпитализацию и оперативное вмеша-тельство. В связи с этим актуален поиск новых предикторов развития ЖТА. Перспективным в этом направлении является выявление перфузионных нарушений миокарда по данным сцинтиграфии с таллием-199, нарушения симпатической иннервации миокарда, оцененные сцинтиграфией с метайодбензилгуанидином (МИБГ), меченным йодом-131, а также определение уровня потенциальных биохимических маркеров фиброза миокарда, таких как галектин-3 и ST2. Ключевые слова: имплантируемый кардиовертер-дефибриллятор, внезапная сердечная смерть, желудочковые та-хиаритмии, сцинтиграфия миокарда, МИБГ, таллий-199, галектин-3, ST2 Конфликт интересов: авторы не заявили о конфликте интересов Для цитирования: Атабеков Т. А., Сазонова С. И., Баталов Р. Е., Попов С. В. Предикторы развития желудочковых тахиаритмий у пациентов с ишемической болезнью сердца и имплантированными кардиовертерами-дефибрил-ляторами // Сибирский медицинский журнал. -2017- . -Т. 32, № 3. -С. 22-28. DOI: 10.29001/2073- -8552-2017 This review article is devoted to the identification of new predictors of the development of ventricular tachyarrhythmias (VA).The implantable cardioverter-defibrillator (ICD) in patients with the presence of risk factors is one of the main ways to prevent sudden cardiac death (SCD) due to VA. At the same time, data of 5 years of follow-up show that such kind of device is effective only in 15-25% of patients. For the reason that ICD implantation is associated with hospitalization and infection complications, there is a need to improve risk stratification and search for new prognostic markers of SCD and VA in order to reduce the number of inefficiently implanted ICDs and to reduce the costs of surgical intervention. In this regard, it is relevant to search for new predictors of VA development. In this field, it is promising to detect the disturbances of myocardial perfusion based on scintigraphy with thallium-199, to diagnose myocardial sympathetic innervation disorders b...

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JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases

Yamagishi¹,

Tamaki²,

Akasaka³

et al. 2021

Circ J

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ABI ankle-brachial index ACC American College of Cardiology ACS acute coronary syndrome AHA American Heart Association APV averaged peak velocity ARH autosomal recessive hypercholesterolemia AS Agatston score ASO arteriosclerosis obliterans ATP adenosine triphosphate BMIPP β-methyl-p-iodophenyl-pentadecanoic acid BNP B-type natriuretic peptide CABG coronary artery bypass grafting CACS coronary artery calcium score CAD coronary artery disease CANM Canadian Association of Nuclear Medicine CanSCMR Canadian Society of Cardiovascular Magnetic Resonance CAR Canadian Association of Radiologists CCS Canadian Cardiovascular Society CCTA coronary CT angiography CDC Centers for Disease Control and Prevention CFR coronary flow reserve CFVR coronary flow velocity reserve CI confidence interval CKD chronic kidney disease CNCS Canadian Nuclear Cardiology Society CPAP continuous positive airway pressure CT computed tomography CTA computed tomography angiography CTDIvol computed omography dose index volume ▋ 2.2.1 Selection of the Lead System and Recording Time Appropriate ECG recording is essential for making a diagnosis of coronary heart disease. Care should be exercised with regard to selection of the electrodes, leads, paste, and lead system to obtain stable recordings during daily activities. The leads that are most likely to reflect ischemic changes are V5-like leads. In particular, lead CM5 is less affected by body movements and has a good detection rate for ischemic changes. 50 A 2-lead system is commonly used, and the AHA guidelines recommend a combination of leads that approximates leads V1 and V5. 51 For capturing ST elevation in patients with variant angina, vertical leads (II, III, and aVF) and approximations to lead V2 or V3 provide a high diagnostic rate. 52 Both circadian and diurnal (dayto-day) variations may exist in relation to the incidence and duration of myocardial ischemia and the extent of ST changes. However, it is difficult to evaluate the influence of diurnal variation based on 24-hour recording, which means that 48-hour recording is desirable for detecting myocardial ischemia and determining the response to treatment. ▋ 2.2.2 Criteria for ST-Segment Changes The diagnostic significance of persistent ST depression on Holter ECG is not high. Rather, detection and evaluation of transient ST-segment changes is more important. The criteria for ST depression are as follows: (1) horizontal or sagging depression of the ST segment by ≥0.1 mV; (2) reaching maximum ST depression after 1 min; and (3) ST depression of ≥0.1 mV lasting for ≥30-60 s compared with the baseline in a controlled state. 49,53-55 ST depression is measured at 0.08 s after the S or J point, and J-type ST depression is not judged to be ischemic ST depression. 52 When counting the number of ischemic episodes, the definition adopted is that each ischemic interval should last for at least 1 min. 56 The criterion for ST elevation is elevation of the ST segment by ≥0.1 mV lasting for ≥30-60 s in leads without Q waves. 49 In patients with chest pain ...

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Serial dual single-photon emission computed tomography of thallium-201 and iodine-123 beta-methyliodophenyl pentadecanoic acid scintigraphy can predict functional recovery of patients with coronary artery disease after coronary artery bypass graft surgery

Abstract: The delta-BMIPP-TDS evaluated by serial (201)Tl and (123)I-BMIPP dual SPECT can predict improvements in cardiac function during the chronic phase of CAD.

Cited by 3 publications

References 24 publications

A low perfusion‐metabolic mismatch in ^99mTl and ¹²³I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement

A low perfusion‐metabolic mismatch in ^99mTl and ¹²³I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement

Predictors of Ventricular Tachyarrhythmias in Patients With Coronary Heart Disease and Implantable Cardioverter-Defibrillators

JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases

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Serial dual single-photon emission computed tomography of thallium-201 and iodine-123 beta-methyliodophenyl pentadecanoic acid scintigraphy can predict functional recovery of patients with coronary artery disease after coronary artery bypass graft surgery

Abstract: The delta-BMIPP-TDS evaluated by serial (201)Tl and (123)I-BMIPP dual SPECT can predict improvements in cardiac function during the chronic phase of CAD.

Cited by 3 publications

References 24 publications

A low perfusion‐metabolic mismatch in 99mTl and 123I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement

A low perfusion‐metabolic mismatch in 99mTl and 123I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement

Predictors of Ventricular Tachyarrhythmias in Patients With Coronary Heart Disease and Implantable Cardioverter-Defibrillators

JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases

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A low perfusion‐metabolic mismatch in ^99mTl and ¹²³I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement

A low perfusion‐metabolic mismatch in ^99mTl and ¹²³I‐BMIPP scintigraphy predicts poor prognosis in systemic sclerosis patients with asymptomatic cardiac involvement