Sequence conservation among orthologous vomeronasal type 1 receptor-like (ora) genes does not support the differential tuning hypothesis in Salmonidae

Johnson, Marc A.; Banks, Michael

doi:10.1016/j.gene.2011.05.029

Cited by 12 publications

(12 citation statements)

References 46 publications

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“…Thus, the other fish possess only one copy of V1R3. Another possible duplication event was also found in V1R2 (ora1) in the lineage of the genus salmo species (Johnson and Banks, 2011).…”

Section: Comparison Of Orthologous V1r Genes Among Teleost Fishmentioning

confidence: 79%

“…The repertoire of the fish V1R gene family is small (i.e., six genes in most species), and it is rigidly maintained in five distantly related model fish species, with the exception that fugu and pufferfish lack V1R2 (Saraiva and Korsching, 2007). Furthermore, the sequences of orthologous V1R genes are highly conserved among distantly related rockfish species (Johansson and Banks, 2011) and also among salmonid species (Johnson and Banks, 2011). These attributes are in striking contrast to other olfactory receptor gene families (e.g., OR, V2R, TAAR), which have large and highly variable gene repertoires owing to extensive lineage-specific expansions (Hashiguchi et al, 2008;Hussain et al, 2009;Nei et al, 2008;Niimura and Nei, 2005).…”

Section: Introductionmentioning

confidence: 99%

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Characterization of V1R receptor (ora) genes in Lake Victoria cichlids

Ota

Nikaido

Suzuki

et al. 2012

Gene

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“…Thus, the other fish possess only one copy of V1R3. Another possible duplication event was also found in V1R2 (ora1) in the lineage of the genus salmo species (Johnson and Banks, 2011).…”

Section: Comparison Of Orthologous V1r Genes Among Teleost Fishmentioning

confidence: 79%

Section: Introductionmentioning

confidence: 99%

Characterization of V1R receptor (ora) genes in Lake Victoria cichlids

Ota

Nikaido

Suzuki

et al. 2012

Gene

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“…In addition to this repertoire, each of the V1Rs is highly conserved among teleost fishes at the DNA sequence level (Saraiva and Korsching, 2007;Ota et al, 2012). For example, comparisons of the V1R sequences among distantly related rockfishes (Johansson and Banks, 2010) as well as nine salmonid species (Johnson and Banks, 2011) revealed that they are all highly conserved among spe-cies. Although the ligands for fish V1Rs remain largely unexplored, the high level of conservation of teleost V1Rs in repertoires as well as in sequence implies that they recognize a very small number of ligands, which are common across a broad range of fish species.…”

Section: Less Diverse V1r Repertoires In Teleost Fishmentioning

confidence: 99%

Evolution of <i>V1R</i> pheromone receptor genes in vertebrates: diversity and commonality

Nikaido

2019

Genes Genet. Syst.

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The vomeronasal organ (VNO) plays a key role in sensing pheromonal cues, which elicit innate responses and induce social and sexual behaviors. The vomeronasal receptor 1 genes, V1Rs, encode members of a pheromone receptor family that are mainly expressed in the VNO. Previous studies have revealed that the V1R family shows extraordinary variety among mammalian species owing to successive gene gains and losses. Because species-specific pheromonal interaction may facilitate species-specific reproductive behaviors, understanding the evolution of V1Rs in terms of their origin, repertoire and phylogeny should provide insight into the mechanisms of animal diversification. Here I summarize recent studies about the V1R family from its initial discovery in the rat genome to extensive comparative analyses among vertebrates. I further introduce our recent findings for V1Rs in a broad range of vertebrates, which reveal unexpected diversity as well as shared features common among lineages.

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“…Multiplex PCR specific target amplification of salmon olfactory receptors A target pool of coho salmon olfactory receptors was identified based upon previously identified putative Atlantic salmon ORs (Johnson and Banks, 2011;Johnstone et al, 2008Johnstone et al, , 2009Johnstone et al, , 2011Johnstone et al, , 2012. From the total pool of putative ORs, a subset of 6-8 ORs from each of the four major receptor classes (MOR, TAAR, OlfC, and ora) were selected based upon sequence dissimilarity (i.e., genes with more sequence dissimilarity within the same major class), relative expression levels, and ability to specifically amplify the target OR mRNA.…”

Section: Exposuresmentioning

confidence: 99%

From the Cover: Cadmium Exposure Differentially Alters Odorant-Driven Behaviors and Expression of Olfactory Receptors in Juvenile Coho Salmon(Oncorhynchus kisutch)

et al. 2016

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Salmon exposed to waterborne metals can experience olfactory impairment leading to disrupted chemosensation. In the current study, we investigated the effects of cadmium (Cd) on salmon olfactory function by modeling an exposure scenario where juvenile salmon transiently migrate through a polluted waterway. Coho were exposed to environmentally relevant concentrations of waterborne Cd (2 and 30 mg/L) for 48 h and (0.3 and 2 lg/L) for 16 days, followed by a 16-day depuration associated with outmigration. Cadmium exposures inhibited behavioral responses towards L-cysteine and conspecific odorants, with effects persisting following the depuration. Behavioral alterations following the 30 mg/L exposure were associated with increased olfactory epithelial gene expression of metallothionein (mt1a) and heme oxygenase (hmox1); reduced expression of olfactory signal transduction (OST) molecules; and reduced expression of mRNAs encoding major coho odorant receptors (ORs). Salmon OR array analysis indicated that Cd preferentially impacted expression of OST and OR markers for ciliated olfactory sensory neurons (OSNs) relative to microvillus OSNs, suggesting a differential sensitivity of these two major OSN populations. Behavioral alterations on exposure to 0.3 and 2 mg/L Cd were associated with increased mt1a, but not with major histological or OR molecular changes, likely indicating disrupted OST as a major mechanism underlying the behavioral dysfunction at the low-level Cd exposures. Laser-ablation mass spectrometry analysis revealed that the OSN injury and behavioral dysfunction was associated with significant Cd bioaccumulation within the olfactory sensory epithelium. In summary, low-level Cd exposures associated with polluted waterways can induce differential and persistent olfactory dysfunction in juvenile coho salmon.

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Sequence conservation among orthologous vomeronasal type 1 receptor-like (ora) genes does not support the differential tuning hypothesis in Salmonidae

Cited by 12 publications

References 46 publications

Characterization of V1R receptor (ora) genes in Lake Victoria cichlids

Characterization of V1R receptor (ora) genes in Lake Victoria cichlids

Evolution of <i>V1R</i> pheromone receptor genes in vertebrates: diversity and commonality

From the Cover: Cadmium Exposure Differentially Alters Odorant-Driven Behaviors and Expression of Olfactory Receptors in Juvenile Coho Salmon(Oncorhynchus kisutch)

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