Sequence and Solution Structure of Cherimolacyclopeptides A and B, Novel Cyclooctapeptides from the Seeds of Annona cherimola.

Abstract

Sequence and Solution Structure of Cherimolacyclopeptides A and B, Novel Cyclooctapeptides from the Seeds of Annona cherimola. -(WELE, A.; LANDON, C.; LABBE, H.; VOVELLE, F.; ZHANG, Y.; BODO*, B.; Tetrahedron 60 (2004) 2, 405-414; Lab. Chim. Subst. Nat., CNRS, Mus. Natl. Hist. Nat., F-75005 Paris, Fr.; Eng.) -Jannicke 19-194

Anxiolytic-like actions of the hexane extract from leaves of Annona cherimolia in two anxiety paradigms: Possible involvement of the GABA/benzodiazepine receptor complex

“…doi:10.1016/j.lfs.2005.05.078 cultivated for its edible fruits (Morton, 1987). The plant is also used in folk medicine as a parasiticide and an insecticide (Kim et al, 2001;Wele et al, 2004). This species, synthesized alkaloids, mainly of the isoquinoline and aporphine groups for which no less than 70 compounds have been isolated (Wele et al, 2004).…”

“…The plant is also used in folk medicine as a parasiticide and an insecticide (Kim et al, 2001;Wele et al, 2004). This species, synthesized alkaloids, mainly of the isoquinoline and aporphine groups for which no less than 70 compounds have been isolated (Wele et al, 2004). It also produces acetogenins (Chen et al, 1999) and dimeric amides (Chen et al, 1998).…”

Cancer Treatment by Caryophyllaceae-Type Cyclopeptides

“…It is shown that this cyclopeptide contains two β-turns and one new type of β-bulge compared with other cyclopeptides. A cytotoxicity study showed that cherimolacyclopeptide A is a potent cytotoxic agent ( IC 50 0.6 µM), but cherimolacyclopeptide B is a weak cytotoxic agent against KB tumor cells ( IC 5 0 45 µM) ( Chart 6 ) ( 58 ). The peptide sequences and information on biological activities of cherimolacyclopeptides are given in Table 6 .…”