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Cancer is one of the leading diseases, which, in the most cases, ends with death and, thus, continues to be a major concern in human beings worldwide. The conventional anticancer agents used in the clinic often face resistance among many cancer diseases. Moreover, heavy financial costs preclude patients from continuing treatment. Bioactive peptides, active in several diverse areas against man’s health problems, such as infection, pain, hypertension, and so on, show the potential to be effective in cancer treatment and may offer promise as better candidates for combating cancer. Cyclopeptides, of natural or synthetic origin, have several advantages over other drug molecules with low toxicity and low immunogenicity, and they are easily amenable to several changes in their sequences. Given their many demanded homologues, they have created new hope of discovering better compounds with desired properties in the field of challenging cancer diseases. Caryophyllaceae-type cyclopeptides show several biological activities, including cancer cytotoxicity. These cyclopeptides have been discovered in several plant families but mainly are from the Caryophyllaceae family. In this review, a summary of biological activities found for these cyclopeptides is given; the focus is on the anticancer findings of these peptides. Among these cyclopeptides, information about Dianthins (including Longicalycinin A), isolated from different species of Caryophyllaceae, as well as their synthetic analogues is detailed. Finally, by comparing their structures and cytotoxic activities, finding the common figures of these kinds of cyclopeptides as well as their possible future place in the clinic for cancer treatment is put forward.

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Surface functionalization of multi-walled carbon nanotubes(MWCNTs) by opioid antagonist drug of Naltrexone via chemical modification of carboxyl groups,using of reagents di cyclohexyl carbodiimide(DCC),1-ethyl-3[3-dimethylaminopropyl] carbodiimide hydrochloride(EDC),N-hydroxysuccinimide(NHS),1-hydroxybenzotriazolemonohydrate(HOBT),O-(Benzotriazole-1-yl)-1,1,3,3-tetramethyluraniumtetrafluoroborate(TBTU),were performed. In synthetic organic chemistry,compounds containing the carbodiimide functionality are dehydration agents and are often used to activate carboxylic acids towards amide or ester formation. Carboxylic acids will react with the carbodiimide to produce the key intermediate as O-acylisourea which can be considered as a carboxylic ester with an activated leaving group.We have used of five carbodiimide reagent to synthesis twelve sample in this work.The resulting materials were characterized by different techniques,such as Fourier transform infraredspectroscopy (FT-IR), Thermogravimetricanalysis (TGA),Raman spectroscopy,Scanning Electron Microscopy (SEM),Field Emission Scanning Electron Microscopy(FESEM),Atomic Force Microscopy(AFM),High performance liquid chromatography(HPLC).

This work presents a novel cascade of chemical functionalization of multi-walled carbon nanotubes(MWCNTs) through chemical modification by an opioid antagonist drug of Naltrexone. Naltrexone-conjugated MWCNTs were synthesized involving the sequential steps of carboxylation, acylation,and finally,Naltrexoneconjugation.The active acyl chlorides in MWCNTs were subsequently mixed with opioid antagonist drug of Naltrexone.The modification of MWCNTs with Naltrexone was investigated by Fourier transform-infrared spectroscopy,Raman spectroscopy,Thermo Gravimetric Analysis,Elemental Analysis,High Performance Liquid Chromatography.Size and surface characteristics of chemically modified MWCNTs were monitored by Transmission Electron Microscopy,Scanning Electron Microscopy,Field Emission Scanning Electron Microscopy,Atomic Force Microscopy.

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