Septicémie à yersinia enterocolitica chez un enfant thalassémique atteint d'appendicite aiguë

Yersinia enterocolitica: the charisma continues

“…Regardless of the exact mode of action, the correlation between iron overload and the use of desferrioxamine as a chelating therapeutic in patients suffering from iron overload and Y. enterocolitica sepsis is well established (27,57,153,157,159). Among the risk factors contributing to iron overload are underlying hematologic dyscrasias such as thalassemia (111,193,204), aplastic anemia (111), sickle cell disease (218), and defects in iron metabolism. Furthermore, Cantinieaux et al (51) have shown an impairment of neutrophil phagocytic and killing activity against Y. enterocolitica in patients with iron overload.…”

Y. enterocolitica and Y. pseudotuberculosis

“…Clinical case descriptions of disseminated infections due to low-pathogenicity Yersinia in iron-overloaded patients are numerous in the literature. This ironoverload status responsible for disseminating Yersinia infections had different origins: oral overdose of iron (Robins-Browne et al, 1979a;Soriano et al, 1981;Melby et al, 1982;Mofenson et al, 1987); iron therapy (Leighton and MacSween, 1987;Fakir et al, 1995); hemodialysis (Boelaert et al, 1987) and long-term transfusion therapy (Schuchmann et al, 1997); and underlying diseases that increase directly or indirectly (through blood transfusions) the iron burden of the patients: 1) hypersideremia without any known etiology (Sibilia et al, 1991), 2) primary hemochromatosis (Jacquenod et al, 1984;M'Rad et al, 1988;Shibuya et al, 1988;Merrien et al, 1991;Vadillo et al, 1994;Collazo et al, 1995;Piroth et al, 1997;Höpfner et al, 2001), 3) thalassemia (Blum et al, 1970;Hewstone and Davidson, 1972;Seigneurin et al, 1972;Rabson et al, 1975;Bouza et al, 1980;Hambourg et al, 1980;Soriano et al, 1981;Adamkiewicz et al, 1998), 4) autoimmune hemolytic anemia (Guez et al, 1987), and 5) liver diseases (Marlon et al, 1971;Seigneurin et al, 1972;Rabson et al, 1975;Imhoof and Auckenthaler, 1980;Soriano et al, 1981;Jacquenod et al, 1984;Merrien et al, 1991).…”

Yersinia enterocolitica: the charisma continues.

“…Regardless of the exact mode of action, the correlation between iron overload and the use of desferrioxamine as a chelating therapeutic in patients suffering from iron overload and Y. enterocolitica sepsis is well established (27,57,153,157,159). Among the risk factors contributing to iron overload are underlying hematologic dyscrasias such as thalassemia (111,193,204), aplastic anemia (111), sickle cell disease (218), and defects in iron metabolism. Furthermore, Cantinieaux et al (51) have shown an impairment of neutrophil phagocytic and killing activity against Y. enterocolitica in patients with iron overload.…”