Yersinia enterocolitica: the charisma continues.

Bottone, E J

doi:10.1128/cmr.10.2.257-276.1997

Cited by 66 publications

(93 citation statements)

References 172 publications

(263 reference statements)

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“…This may indicate a high rate of subclinical yersiniosis in the healthy population. Yersinia enterocolitica can cause gastrointestinal symptoms ranging from mild self-limiting diarrhoea to acute mesenteric lymphadenitis, which can lead to appendicitis (Bottone, 1997). The clinical manifestations of the infection depend to some extent on the age and physical state of the patient, the presence of any underlying medical conditions and the bioserotype of the organism.…”

Section: Yersinia Enterocolitica Infectionmentioning

confidence: 99%

“…Secondary immunologically induced sequelae, such as reactive arthritis, are not uncommon, especially in HLA-B27-positive individuals. Most cases of yersiniosis occur sporadically without an apparent source (Bottone, 1997(Bottone, , 1999. Yersinia enterocolitica is thought to be a significant food-borne pathogen, even though pathogenic strains have seldom been isolated from foods.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Molecular epidemiology ofYersinia enterocoliticainfections

Fredriksson-Ahomaa

Stolle

Korkeala

2006

FEMS Immunology &Amp; Medical Microbiology

175

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Yersinia enterocolitica is an important food-borne pathogen that can cause yersiniosis in humans and animals. The epidemiology of Y. enterocolitica infections is complex and remains poorly understood. Most cases of yersiniosis occur sporadically without an apparent source. The main sources of human infection are assumed to be pork and pork products, as pigs are a major reservoir of pathogenic Y. enterocolitica. However, no clear evidence shows that such a transmission route exists. Using PCR, the detection rate of pathogenic Y. enterocolitica in raw pork products is high, which reinforces the assumption that these products are a transmission link between pigs and humans. Several different DNA-based methods have been used to characterize Y. enterocolitica strains. However, the high genetic similarity between strains and the predominating genotypes within the bio- and serotype have limited the benefit of these methods in epidemiological studies. Similar DNA patterns have been obtained among human and pig strains of pathogenic Y. enterocolitica, corroborating the view that pigs are an important source of human yersiniosis. Indistinguishable genotypes have also been found between human strains and dog, cat, sheep and wild rodent strains, indicating that these animals are other possible infection sources for humans.

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Section: Yersinia Enterocolitica Infectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular epidemiology ofYersinia enterocoliticainfections

Fredriksson-Ahomaa

Stolle

Korkeala

2006

FEMS Immunology &Amp; Medical Microbiology

175

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“…The ability to produce the siderophore yersiniabactin might be one of the important virulence traits supplying BG 1B strains with iron that is necessary to establish an infection [20]. On the other hand, predominantly low-virulent siderophore-negative Y. enterocolitica ST (O:3, O:9, O:5,27) have been recovered from patients with transfusion-associated bacteremia [3]. Also post-yersinial secondary seque-lae are mostly associated with Y. enterocolitica O:3 infections [12].…”

Section: Introductionmentioning

confidence: 99%

“…Also post-yersinial secondary seque-lae are mostly associated with Y. enterocolitica O:3 infections [12]. Nosocomial infections with Y. enterocolitica O:9 have been documented, but also strains belonging to normally avirulent serobiotypes such as O:5, BG 1A or O:6,30, BG 1A may cause an infection [3,24]. Thus, serotype-, biogroup-or even strain-speci¢c markers might be responsible for the noted di¡erences in clinical manifestations of yersiniae.…”

Section: Introductionmentioning

confidence: 99%

Uncovering genomic differences in human pathogenicYersinia enterocolitica

Golubov¹,

Heesemann²,

Rakin³

2003

FEMS Immunology &Amp; Medical Microbiology

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To map out genomic differences between highly pathogenic Yersinia enterocolitica WA-314C biogroup 1B, serotype O:8 strain and low-pathogenic Y. enterocolitica Y-108C biogroup 4, serotype O:3 strain we have applied a method of suppression subtractive hybridization (SSH). In total, 428 WA-314-specific and 83 Y-108-specific sequences were uncovered by SSH. Among them were DNA fragments with similarity to known genes from several groups: (1) genes involved in O-antigen biosynthesis, (2) host-specific restriction-modification systems, (3) systems of iron and heme acquisition and storage, (4) flagellar biogenesis genes, (5) putative virulence factors, (6) drug resistance genes, and (7) mobile elements. Mapped out genomic differences may be applied in identification and development of novel therapeutic strategies for the treatment of enteropathogenic Yersinia.

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“…Although nutrition is generally considered to be an important variable for infectious diseases, it is important to acknowledge that the relationship between nutritional status and many infectious disease has not been carefully studied. Iron overload is known to predispose to Yersinia enterocolitica (56). Less commonly known is that improved nourishment may exacerbate the course of certain infectious diseases, a fact noted before modern medicine, when it was observed that smallpox had greater mortality among the wealthy (57).…”

Section: Susceptibility Attributesmentioning

confidence: 99%

What Is a Host? Attributes of Individual Susceptibility

Casadevall

Pirofski

2018

Infect Immun

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In every epidemic some individuals become sick and some may die, whereas others recover from illness and still others show no signs or symptoms of disease. These differences highlight a fundamental question of microbial pathogenesis: why are some individuals susceptible to infectious diseases while others who acquire the same microbe remain well? For most of human history, the answer assumed the hand of providence. With the advent of the germ theory of disease, the focus on disease causality became the microbe, but this did not explain how there can be different outcomes of infection in different individuals with the same microbe. Here we examine the attributes of susceptibility in the context of the "damage-response framework" of microbial pathogenesis. We identify 11 attributes that, although not independent, are sufficiently distinct to be considered separately: microbiome, inoculum, sex, temperature, environment, age, chance, history, immunity, nutrition, and genetics. We use the first letter of each to create the mnemonic MISTEACHING, underscoring the need for caution in accepting dogma and attributing disease causality to any single factor. For both populations and individuals, variations in the attributes that assemble into MISTEACHING can create an enormity of combinations that can in turn translate into different outcomes of host-microbe encounters. Combinatorial diversity among the 11 attributes makes identifying "signatures" of susceptibility possible. However, with their inevitable uncertainties and propensity to change, there may still be a low likelihood for prediction with regard to individual host-microbe interactions, although probabilistic prediction may be possible.

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Yersinia enterocolitica: the charisma continues.

Cited by 66 publications

References 172 publications

Molecular epidemiology ofYersinia enterocoliticainfections

Molecular epidemiology ofYersinia enterocoliticainfections

Uncovering genomic differences in human pathogenicYersinia enterocolitica

What Is a Host? Attributes of Individual Susceptibility

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