Sepse tardia em pré-termos de uma unidade de terapia intensiva neonatal: análise de três anos

Freitas, Brunnella Alcântara Chagas de; Peloso, Mirene; Manella, Lilyane Damasceno; Franceschini, Sylvia do Carmo Castro; Longo, Giana Zarbato; Gomes, Andréia Patrícia; Siqueira-Batista, Rodrigo

doi:10.1590/s0103-507x2012000100012

Cited by 21 publications

(21 citation statements)

References 23 publications

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“…The present study demonstrated that a higher number of packed red blood cell transfusions were performed in premature infants with a GA <32 weeks and with late-onset neonatal sepsis. Freitas et al (31) recently observed that the highest occurrence of lateonset sepsis was correlated with younger gestational ages. Anemia is multifactorial in severe infections due to the inhibition of erythropoiesis, hemolysis and blood loss.…”

Section: Discussionmentioning

confidence: 97%

“…(32) Therefore, the identification of risk factors and the implementation of strategies to reduce late-onset sepsis, including hand washing, nutrition, skin care, respiratory treatment, and vascular access, are required. (31,34,35) All of the premature infants that developed BPD, severe PIVH, and NEC received transfusions, despite exclusion from the regression model. This result may be explained by the young gestational ages at these morbidities occur and the increased clinical severity due to inflammation and blood loss.…”

Section: Discussionmentioning

confidence: 99%

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Fatores associados à transfusão de concentrado de hemácias em prematuros de uma unidade de terapia intensiva

Freitas

Franceschini

2012

Rev. bras. ter. intensiva

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Factors associated with packed red blood cell transfusions in premature infants in an intensive care unit Fatores associados à transfusão de concentrado de hemácias em prematuros de uma unidade de terapia intensiva ORIGINAL ARTICLE INTRODUCTION Anemia occurs frequently in premature infants, which makes this population prone to transfusion treatments. (1) Packed red blood cells are the most frequently administered blood products to newborns, and these transfusions are generally necessary in two situations: 1) to guarantee adequate tissue oxygenation during intensive care treatment and 2) to treat significantly symptomatic anemia. (2) The repercussions of transfusions and the adoption of policies to reduce blood transfusions have become enormous challenges because more premature newborns survive anemia. (1) Preterm infants with gestational ages <30 weeks, birth weights <1,000 g, or severe infectious diseases are candidates for blood transfusions. (3) Several reasons may underlie the occurrence of anemia in premature infants. The time to cut the umbilical cord in the delivery room determines the newborn's hematocrit. Delays in the clamping of the umbilical cord increases the blood volume shortly after birth, which improves

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Fatores associados à transfusão de concentrado de hemácias em prematuros de uma unidade de terapia intensiva

Freitas

Franceschini

2012

Rev. bras. ter. intensiva

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“…The research is particularly relevant in Brazil due to the high prevalence of E. coli in the country. Studies published by Freitas et al, (2012) and Pinheiro et al, (2009) mentioned neonatal infection rates between 28.5% and 30.6% for Grampositive and Gram-negative bacteria. The DNA amplification of E. coli by PCR is a sensitive, specific and easily performed technique, and does not require cell culture.…”

Section: Discussionmentioning

confidence: 99%

Neonatal sepsis: evaluation of risk factors and histopathological examination of placentas after delivery

Duarte¹,

Marcon²,

Akagi³

et al. 2019

Biosci. J.

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Neonatal sepsis is a clinical syndrome defined by systemic signs of infection in newborns accompanied by bacteremia. Can be responsible for serious consequences for the newborn child, characterized at the birth as early sepsis or late onset sepsis, with high rate of neonatal morbidity and mortality. Pathological agents such as Escherichia coli (E. coli), Streptococcus agalactiae (S. agalactiae), Ureaplasma urealyticum and Mycoplasma hominis are most often responsible for intrauterine infections. The objective of this study is to evaluate the factors of neonatal sepsis predisposition in pregnant women through histopathological examination and the apoptotic index of placental tissues and detect DNA of E. coli and S. agalactiae using the Polymerase Chain Reaction (PCR). Histopathological analyses were made and the apoptotic index was determined to verify the levels of possible inflammatory infiltrates and cell death. Placenta samples were collected from November 2013 to May 2014. After DNA extraction, a PCR was performed amplifying the target fragment from the conserved regions of the rpoB (beta-RNA polymerase) polymorphism of E. coli and the factor 1 of S. agalactiae. The apoptosis index was tested with Acridine Orange and the histological procedure with Hematoxylin-Eosin staining. Among 100 samples of placental tissues analyzed by PCR, 48 represented the control group and did not present a risk factor associated with neonatal sepsis, and 52 samples representing the study group had at least one risk factor. Among these 52 samples, 7 (13.4%) had a PCR positive for E. coli. No placenta samples showed a positive PCR for S. agalactiae. The quantification of the apoptotic index did not show statistical significances between the groups and no inflammatory infiltrates were observed. However, histological sections showed fibrinoid necrosis, infarct areas and areas of calcification in all samples. Therefore, the results allow to conclude that the seven patients of experimental group with positive PCR for E. coli had eminent risk factors of neonatal sepsis, and the infection of the urinary tract (UTI) is the main aggravating circumstance. The histopathological examination demonstrated that the risk factors caused significant alterations, producing fibrinoid necrosis and infarcted areas in the placenta, contrary to apoptotic index that didn't differ from the group with unprecedented risk.

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“…The cost of septic patients in the United States is $14 billion per year [4]. Therefore, from the clinical and public health perspective it is an extremely important condition, not only because of its high incidence, but also because of its mortality [5,6].…”

Section: Introductionmentioning

confidence: 99%

Pro-Inflammatory Cytokines in Sepsis: Biological Studies and Prospects From In Silico Research

Gomes¹,

Miguel²

2015

Biol syst Open Access

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Sepse tardia em pré-termos de uma unidade de terapia intensiva neonatal: análise de três anos

Cited by 21 publications

References 23 publications

Fatores associados à transfusão de concentrado de hemácias em prematuros de uma unidade de terapia intensiva

Fatores associados à transfusão de concentrado de hemácias em prematuros de uma unidade de terapia intensiva

Neonatal sepsis: evaluation of risk factors and histopathological examination of placentas after delivery

Pro-Inflammatory Cytokines in Sepsis: Biological Studies and Prospects From In Silico Research

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