Separation of enantiomers of drugs by capillary electrophoresis Part 8. β-Cyclodextrin as chiral solvating agent

Enantiomeric separation of antimalarial drugs by capillary electrophoresis using neutral and negatively charged cyclodextrins

“…Our novel results supplements series of enantioseparations for CLQ, MFQ reported elsewhere [14][15][16][17][18][19][20][21][22][23][24][25][26][27][28]. In addition, baseline or improved resolutions of QR and TFQ by CD-CZE could be demonstrated.…”

“…Although, excellent enantiomeric separations have been achieved in case of PRQ [5][6][7][8][9][10][11][12][13], CLQ [14][15][16][17][18][19][20][21][22][23][24] and MFQ [19][20][21][22][23][24][25][26][27][28] …”

Thin‐layer chromatography separation of enantiomers of verapamil using macrocyclic antibiotic as a chiral selector

“…Enantiomers of verapamil have been resolved by capillary electrophoresis using trimethyl-β-cyclodextrin (Rui et al, 1998), β-cyclodextrin (Lin et al, 1998), methylated glucuronyl glucosyl β-cyclodextrin (Matsunaga et al, 2002), hydropropyl-β-cyclodextrin (Zhang et al, 2002), carboxymethyl derivatives of polysaccharides (Nishi et al, 2001), L-leucine (Lin et al, 2001), permethyl-γ-cyclodextrin (Koppenhoefer et al, 2000) and heptakis(2,3-dimethyl-6-sulfato)-β-cyclodextrin (Tacker et al, 1999).…”

Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma‐cyclodextrin as chiral solvating agent

“…The three closely related structures (Fig. 3) allow the identification of systematic changes in the electrophoretic behaviour, dependent on the ring size of the cyclodextrin added (see Table 3; some of these data were reported previously 23,24 ). The cavity diameter is known as 5.7, 7.8, and 9.5 Å for ␣-, ␤-, and ␥-cyclodextrin, respectively.…”

“…Eventually, a total of 86 entries have been included in the screening program. [15][16][17][18][19][20] Following a prestudy, 15 we report here on the application of ␥-CD to 86 drug racemates.…”