Separation of enantiomers of drugs by capillary electrophoresis, part 7: Gamma‐cyclodextrin as chiral solvating agent

Rôles des sidérophores bactériens et de mammifères dans les interactions hôtes-pathogènes

“…D'autres molécules naturelles de ce type sont décrites dans la littérature comme les microcines [38]. Aujourd'hui, plusieurs équipes essaient de développer des molécules synthétiques de ce type (pour revue voir [35,[38][39][40] , une augmentation du pool de fer intracellulaire est observée. En revanche, en présence d'apo-NGAL, les cellules meurent par une apoptose induite par la diminution du fer intracellulaire, un effet cytotoxique déjà décrit pour certains chélateurs du fer [44], avec un export du métal par exocytose dans le milieu de culture sous la forme d'holo-NGAL.…”

Separation of drug enantiomers by capillary electrophoresis in the presence of neutral cyclodextrins

“…(Herfigures defined in our previous publications, i.e., the cules, CA,USA). Meanwhile, we have obtained a migration separation factor (a ) [11], and the m significant number of comparable data [10][11][12][13][14][15][16][17][18][19][20] for migration retardation factor (R ) [11] were comm neutral cyclodextrins, whereas the utility of charged pared with recently published data for native bcyclodextrins will be covered in a forthcoming stage cyclodextrin (b-CD) [12,17]. This comparison may of the project.…”

“…3 CSAs is hindered by the low solubility of b-CD in the electrophoretic data [26], we choose to divide the the running buffer. total of 86 chiral drugs into two classes, according to Likewise, analytes containing the substructure 4H their chemical structure, one class where the subhave a higher affinity, as judged from the fraction of structure 4H [16] (see Fig. 2) is present, and another R .1.5, to the two cyclodextrins than analytes m class where 4H is absent.…”

“…The three closely related structures (Fig. 14) allow to identify systematic changes in the electrophoretic behaviour, dependent on the ring size of the cyclodextrin added, see Table 4 [ [16][17][18]. The cavity diameter is known as 5.7, 7.8, and 9.5 A for a-, b-, and g-cyclodextrin, respectively [32].…”

“…?C-H axis does not fit in a horizontal orientation (as depicted in Fig. 15) into the a-cyclodextrin cone; instead, a partial inclusion (''side-on-binding'') is deemed the most likely possibility [16]. The cavity of b-cyclodextrin is just sufficiently large to accommodate a whole benzene ring, but the substituents in ortho-position may sterically restrict the degree of inclusion.…”