Separation of D, L-amino acids using ligand exchange membranes

Keating, John J.; Bhattacharya, S.; Belfort, Georges

doi:10.1016/j.memsci.2018.03.030

Cited by 37 publications

(21 citation statements)

References 17 publications

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“…At the present time, amino acids for agriculture and biomedicine are obtained by microbiological synthesis, hydrolysis of connective tissues or chemical synthesis (Cartus 2012;Keating et al 2018). Whereas in the first and second cases mainly L-isomers of amino acids are produced, in the latter case only racemic L, D-mixtures are produced (for example, by the ammonolysis of alpha halo carboxylic acids).…”

Section: Stereoisomerism Of D-amino Acidsmentioning

confidence: 99%

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D-amino acids in nature, agriculture and biomedicine

et al. 2019

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Information accumulated over the past decades on the physiological functions and metabolic pathways of biosynthesis and degradation of D-amino acids has led to a renewed interest in their study. These isomers are known to form both in nature and during the chemical synthesis of L-amino acids for feeding and pharmacological purposes, as well as in the industrial processing of some raw materials. This article discusses the positive and negative effects of D-amino acids on the human body, animals and the environment. In addition, the scientific data concerning the mechanisms of cytotoxic action of D-amino acids and their industrial and biomedical potential are summarized. ARTICLE HISTORY

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Section: Stereoisomerism Of D-amino Acidsmentioning

confidence: 99%

“…In recent years, chromatography on selective chiral sorbents has been increasingly used for separation of racemic mixtures (Keating et al 2018).…”

Section: Stereoisomerism Of D-amino Acidsmentioning

confidence: 99%

D-amino acids in nature, agriculture and biomedicine

et al. 2019

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“…It could be inferred from the selectivity coefficients that the L‐Phe@MIPs in present study showed relatively high selectivity ( K L = 4.11). Additionally, the e.e.% of L‐Phe on L‐Phe@MIPs was estimated as 78, which was not high enough compared with other resolution methods . However, this imprinted material was still potential to resolve racemic phenylalanine if it could be further modified in future experiments.…”

Section: Resultsmentioning

confidence: 94%

Highly selective recognition of L‐phenylalanine with molecularly imprinted polymers based on imidazolyl amino acid chiral ionic liquid

et al. 2019

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Several amino acid chiral ionic liquids were introduced as functional monomers to prepare molecularly imprinted polymers for specific recognition of Lphenylalanine. Among them, the imprinted polymers L-Phe@MIPs based on[ViImC3][L-Pro] showed the best selective recognition ability for Lphenylalanine. A series of experiments such as dynamic adsorption, static adsorption, and competitive adsorption were conducted to investigate the specific recognition ability and adsorption capacity of the L-Phe@MIPs. It is found that the adsorption efficiency to L-phenylalanine on L-Phe@MIPs was 3.11 times higher than that to D-phenylalanine. All the results demonstrated that the L-Phe@MIPs possessed good recognition and relatively high adsorption efficiency for L-phenylalanine. Besides, the recovery of L-phenylalanine was above 98%, and the L-Phe@MIPs exhibited good reusability.

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“…The membrane's advantages over other separation methods in the previous sections are discussed in detail. As a new result of the use of membranes in the separation of racemic mixtures, modifying the regenerated cellulose membrane with chiral L-proline-copper complexes [195] through an intermediate epoxy-silane surface functionalization reaction for various times is a good example (Figure 23).…”

Section: Isolation Of Enantiomer In Racemic Mixtures By Membranementioning

confidence: 99%

“…This chiral copper complex has various powers of coordination interactions with different enantiomers based on their space chemistry (stereochemistry) [195]. In this work, the ligand exchange chemistry is used to create membranes capable of separating the mixture of amino acids and potentially other drug substances that have functional groups capable to ligating with the metal complex.…”

Section: Isolation Of Enantiomer In Racemic Mixtures By Membranementioning

confidence: 99%

Membrane and Bioseparation

Mansourpanah¹,

Emamian²

2020

Advances in Membrane Technologies

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Although one of the strongest methods of purification is chromatography, the major problem of porous bed chromatography is that purification takes place using the diffusion. This will prolong the purification process and bring down the efficiency. In recent years, membrane methods have greatly overcome this limitation due to low membrane thickness, low pressure drop, and convective flow, and they are a great alternative to chromatography columns. Unfortunately, the membranes have a low surface area. For solving such problem, membrane modification with polymeric brushes and layer-by-layer adsorption in polyelectrolyte films can be attractive. Accordingly, in this chapter we introduce types of biomolecule purification methods, the best purification method, membrane modification techniques, and their limitations and assets. Also, we introduce the membrane as an attractive tool for selective purification and separation of biomolecules.

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Separation of D, L-amino acids using ligand exchange membranes

Cited by 37 publications

References 17 publications

D-amino acids in nature, agriculture and biomedicine

D-amino acids in nature, agriculture and biomedicine

Highly selective recognition of L‐phenylalanine with molecularly imprinted polymers based on imidazolyl amino acid chiral ionic liquid

Membrane and Bioseparation

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