Highly selective recognition of L‐phenylalanine with molecularly imprinted polymers based on imidazolyl amino acid chiral ionic liquid

Abstract

Several amino acid chiral ionic liquids were introduced as functional monomers to prepare molecularly imprinted polymers for specific recognition of Lphenylalanine. Among them, the imprinted polymers L-Phe@MIPs based on[ViImC3][L-Pro] showed the best selective recognition ability for Lphenylalanine. A series of experiments such as dynamic adsorption, static adsorption, and competitive adsorption were conducted to investigate the specific recognition ability and adsorption capacity of the L-Phe@MIPs. It is found that the adsorption efficiency to L-phenylalanine on L-Phe@MIPs was 3.11 times higher than that to D-phenylalanine. All the results demonstrated that the L-Phe@MIPs possessed good recognition and relatively high adsorption efficiency for L-phenylalanine. Besides, the recovery of L-phenylalanine was above 98%, and the L-Phe@MIPs exhibited good reusability.

Molecularly Imprinted Polymers Specific towards 4-Borono-L-phenylalanine—Synthesis Optimization, Theoretical Analysis, Morphology Investigation, Cytotoxicity, and Release Studies

“…In the following step of the investigation, we aimed to construct the MIP with enhanced binding capacity. It is known from the literature survey that more sophisticated D- and L-phenylalanine imprinted systems, such as MIP conjugates with gold nanoparticles [ 30 ] or MIPs synthesized in the presence of chiral ionic liquids [ 31 ], could affect the binding capacity of the resulted materials, being promising sorbents for separation purposes. However, it should be emphasized that the application of those systems for BNCT could be limited due to biosafety reasons.…”

Preparation of amino acid chiral ionic liquid and visual chiral recognition of glutamine and phenylalanine enantiomers

“…The synthesis of AACIL was obtained and modified according to the literature 32,33 . The synthesis route is shown in Figure 1.…”

“…The synthesis of AACIL was obtained and modified according to the literature. 32,33 The synthesis route is shown in Figure 1. 1. 1-methylimidazole was mixed with 1-bromoethane and stirred back at 70 C for 24 hours, the product was washed with ethyl ether and the unreacted bromoethane was removed to obtain 1-ethyl-3-methylimidazole bromide ([EMIM]Br).…”