Membrane and Bioseparation

Abstract

Although one of the strongest methods of purification is chromatography, the major problem of porous bed chromatography is that purification takes place using the diffusion. This will prolong the purification process and bring down the efficiency. In recent years, membrane methods have greatly overcome this limitation due to low membrane thickness, low pressure drop, and convective flow, and they are a great alternative to chromatography columns. Unfortunately, the membranes have a low surface area. For solving such problem, membrane modification with polymeric brushes and layer-by-layer adsorption in polyelectrolyte films can be attractive. Accordingly, in this chapter we introduce types of biomolecule purification methods, the best purification method, membrane modification techniques, and their limitations and assets. Also, we introduce the membrane as an attractive tool for selective purification and separation of biomolecules.

Advances in Biohybridized Planar Polymer Membranes and Membrane‐Like Matrices

“…One major advantage of this system is the possibility of designing environmentally-responsive membranes that can promote selective separation. [140] One of the examples of polymer membranes use is pervaporation membranes, for instance in the separation of volatile compounds from solutions. In recent years, several studies have been established to fabricate polymer-based high performance pervaporation membranes with reduced energy consumption and improved efficiency for industrial biofuel production.…”

Surface Engineering of a Bioartificial Membrane for Its Application in Bioengineering Devices

“…; ceramics materials like silica, titania, and zirconia; and biodegradable polymers such as collagen, chitosan, alginate, etc. , These material-based BAMs provide an opportunity to be tailored for properties like thermomechanical stability, chemical resistance, biocompatibility, hemocompatibility, porosity, shear resistance, fouling, biofilm formation, etc., that are essential to withstand different stresses and perform the designated functions in biomedical devices . For instance, biocompatibility, porosity, antifouling, and antibacterial properties are very essential properties when BAMs are explored for tissue engineering applications, whereas surface properties, pore size, chemical reactivity, and hemo-compatibility of BAMs are essential when explored in filtration/separation processes . Although there is a plethora of literature that describes the BAMs in different applications, there has been limited effort to consolidate the knowledge of the design and fabrication of BAMs to have the requisite surface properties needed to achieve different bioengineering applications.…”

“…23 For instance, biocompatibility, porosity, antifouling, and antibacterial properties are very essential properties when BAMs are explored for tissue engineering applications, whereas surface properties, pore size, chemical reactivity, and hemo-compatibility of BAMs are essential when explored in filtration/ separation processes. 24 Although there is a plethora of literature that describes the BAMs in different applications, there has been limited effort to consolidate the knowledge of the design and fabrication of BAMs to have the requisite surface properties needed to achieve different bioengineering applications. In this review, we have discussed the chemical composition of different bioartificial membranes, their fabrication techniques, major challenges faced by membrane-like fouling, and their wide range of applications that have been explored in the last 10 years' time.…”