Separation detection of different circulating tumor cells in the blood using an electrochemical microfluidic channel modified with a lipid-bonded conducting polymer

Gurudatt, N.G.; Chung, Saeromi; Kim, Jungmin; Kim, Moo-Hyun; Jung, Dong Keun; Han, Jinyoung; Shim, Yoon‐Bo

doi:10.1016/j.bios.2019.111746

Cited by 28 publications

(34 citation statements)

References 24 publications

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“…An interesting method for the electrochemical detection of CTCs within a microfluidic channel was proposed by Gurudatt et al ( Figure 15 ) [ 128 ]. Cells differing in their size, surface charge, and chemical state on the cell surface were effectively separated using such a device.…”

Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning

confidence: 99%

“…Finally, the device was applied for the detection of CTCs from 37 cancer patients with (92.0 ± 0.5)% efficiency. The results showed differences in the retention time for different types of CTCs produced by different cancer types, suggesting differences in the size, surface charge, and chemical state on the cellular surface [ 128 ]. Another microfluidic electrochemical approach for the detection of CTCs was based on the measurement of changes in the impedance of the polydimethylsiloxane-based channel on a glass slide during the passage of CTCs [ 129 ].…”

Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning

confidence: 99%

See 1 more Smart Citation

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Gajdošová

Lorencová

Kasák

et al. 2020

Sensors

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This comprehensive review paper describes recent advances made in the field of electrochemical nanobiosensors for the detection of breast cancer (BC) biomarkers such as specific genes, microRNA, proteins, circulating tumor cells, BC cell lines, and exosomes or exosome-derived biomarkers. Besides the description of key functional characteristics of electrochemical nanobiosensors, the reader can find basic statistic information about BC incidence and mortality, breast pathology, and current clinically used BC biomarkers. The final part of the review is focused on challenges that need to be addressed in order to apply electrochemical nanobiosensors in a clinical practice.

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Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning

confidence: 99%

Section: Nanomaterials/nanoparticles-based Electrochemical Biosensmentioning

confidence: 99%

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Gajdošová

Lorencová

Kasák

et al. 2020

Sensors

View full text Add to dashboard Cite

show abstract

“…The detection of CTC is based on the redox reaction of DM (daunomycin) molecules (coated on the CTC) to generate electrical signals. Blood samples from 37 cancer patients were tested with 90.9% detection rate ( Figure 5A) [128].…”

Section: Other Assaysmentioning

confidence: 99%

“…(A) Modified the surface of the channel with lipid bilayer, and realized CTC separation and detection by applying AC electric field. Reprinted with permission from ref[128]. Copyright 2019, Elsevier.…”

mentioning

confidence: 99%

Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Han

Sun

et al. 2020

Sensors

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Circulating tumor cells (CTCs) are tumor cells that escaped from the primary tumor or the metastasis into the blood and they play a major role in the initiation of metastasis and tumor recurrence. Thus, it is widely accepted that CTC is the main target of liquid biopsy. In the past few decades, the separation of CTC based on the electrochemical method has attracted widespread attention due to its convenience, rapidness, low cost, high sensitivity, and no need for complex instruments and equipment. At present, CTC detection is not widely used in the clinic due to various reasons. Point-of-care CTC detection provides us with a possibility, which is sensitive, fast, cheap, and easy to operate. More importantly, the testing instrument is small and portable, and the testing does not require specialized laboratories and specialized clinical examiners. In this review, we summarized the latest developments in the electrochemical-based CTC detection and point-of-care CTC detection, and discussed the challenges and possible trends.

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“…The introduction of nanomaterials in electrochemical analysis increases the conductivity and surface area of electrodes, thus improves the catalytic activity. These properties can improve the sensor detection sensitivity, shorten the response time, and realize the real-time monitoring of the detector (Gurudatt et al, 2019;Hrichi et al, 2019). Nanomaterials are modified onto the surface of electrochemical sensors to capture biomolecules and improve the immobilization efficiency and the sensitivity of the sensors.…”

Section: Introductionmentioning

confidence: 99%

Recent Development of Graphene Based Electrochemical Sensor for Detecting Hematological Malignancies-Associated Biomarkers: A Mini-Review

et al. 2021

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Hematologic malignancies are a group of malignant diseases of the hematologic system that seriously endanger human health, mainly involving bone marrow, blood and lymphatic tissues. However, among the available treatments for malignant hematologic diseases, low detection rates and high recurrence rates are major problems in the treatment process. The quantitative detection of hematologic malignancies-related biomarkers is the key to refine the pathological typing of the disease to implement targeted therapy and thus improve the prognosis. In recent years, bioelectrochemical methods for tumor cell and blood detection have attracted the attention of an increasing number of scientists. The development of biosensor technology, nanotechnology, probe technology, and lab-on-a-chip technology has greatly facilitated the development of bioelectrochemical studies of cells, especially for blood and cell-based assays and drug resistance differentiation. To improve the sensitivity of detection, graphene is often used in the design of electrochemical sensors. This mini-review provides an overview of the types of hematological malignancies-associated biomarkers and their detection based on graphene assisted electrochemical sensors.

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Separation detection of different circulating tumor cells in the blood using an electrochemical microfluidic channel modified with a lipid-bonded conducting polymer

Cited by 28 publications

References 24 publications

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Electrochemical Nanobiosensors for Detection of Breast Cancer Biomarkers

Electrochemical Detection and Point-of-Care Testing for Circulating Tumor Cells: Current Techniques and Future Potentials

Recent Development of Graphene Based Electrochemical Sensor for Detecting Hematological Malignancies-Associated Biomarkers: A Mini-Review

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