Sentinel Node Biopsy for Oral and Oropharyngeal Squamous Cell Carcinoma of the Head and Neck

Stoeckli, Sandro J.

doi:10.1097/mlg.0b013e318093ee67

Cited by 134 publications

(131 citation statements)

References 42 publications

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“…If occult metastases were identified, a completion modified radical neck dissection was performed in the same sitting. 17 Patients whose definitive histology showed a positive SNB underwent interval neck dissection.…”

Section: Methodsmentioning

confidence: 99%

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High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

Züllig

Roessle

Weber

et al. 2013

European Journal of Cancer

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Section: Methodsmentioning

confidence: 99%

“…To clarify a potential prognostic relevance for occult metastasis of SOX2 protein expression, we consequently analysed a very well defined patient cohort with early oral SCC (T1/T2-stage) undergoing sentinel lymph node biopsy. 16,17 …”

Section: Introductionmentioning

confidence: 99%

High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

Züllig

Roessle

Weber

et al. 2013

European Journal of Cancer

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“…Meanwhile, sentinel node biopsy (SNB) for the cN0 neck in early HNSCC of the oral cavity has been validated by multiple studies and has become one of the standards of care. 10 However, as clinical and conventional histologic parameters have failed to predict occult disease with reliable certainty, 11 the search has to be extended to additional markers with the potential to predict nodal metastases and, therefore, to select patients for neck dissection.…”

mentioning

confidence: 99%

Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx

Huber

Fritzsche

Züllig

et al. 2011

Intl Journal of Cancer

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In patients with early head and neck squamous cell carcinoma (HNSCC), occult lymph node metastasis is difficult to predict by clinical or pathological parameters. However, such parameters are necessary to select patients either for elective neck dissection or the sentinel lymph node (SLN) procedure. The membrane glycoprotein podoplanin is normally expressed in lymphatic endothelial cells. Recently, expression of podoplanin by cancer cells was demonstrated to promote tumor cell motility and tumor lymphangiogenesis in vitro. The value of cancer cell-expressed podoplanin was to be determined as a predictive marker for SLN metastasis in early HNSCC of the oral cavity and oropharynx. One hundred twenty patients with HNSCC of the oral cavity and oropharynx undergoing a SLN biopsy were enrolled in this prospective clinical trial of SLN biopsy. Cancer cell-expressed podoplanin was determined by immunohistochemistry using tissue microarrays. Podoplanin expression was quantified by the intensity reactivity score and categorized into expression and nonexpression. SLN examination revealed occult metastasis in 45 patients (37.5%). Twenty-nine of 120 (24.2%) primary HNSCC showed podoplanin expression. Podoplanin expression correlated significantly with SLN metastasis (p 5 0.029) and remained a significant predictor for lymph node status even after controlling for tumor stage (p 5 0.028). As a predictive marker for SLN metastasis, however, podoplanin expression reached a sensitivity of a mere 36% and a specificity of 83%. Podoplanin expression is associated with metastasis to lymph nodes in vivo. Podoplanin immunohistochemistry in early HNSCC of the oral cavity and oropharynx may help to select patients for the SLN procedure and to identify patients with increased risk for presence of occult lymph node metastasis in the neck.Head and neck squamous cell carcinoma (HNSCC) is the fifth most common malignancy worldwide and responsible for more than 7,800 deaths per year in the United States alone. 1 Despite improvements in surgical treatment and radiation technology over the last decades, survival has not significantly improved. A chief feature of malignant behavior is the capability of tumor cells to metastasize to other organs. Metastasis of many human cancers, including HNSCC, occurs primarily through the lymphatic system. The cellular mechanisms responsible for the acquisition of a metastatic phenotype include the adaptation to potential hostile environment (blood stream, lymph nodes and organ of metastasis). In addition, the ''tumor cell-to-tumor cell'' and ''tumor cell-to-stromal environment'' cross talk is recognized as an important condition for invasion and metastasis.Very recently, expression of the 38-kDa Type 1 transmembrane glycoprotein podoplanin has been shown to induce tumor lymphangiogenesis and enhance metastasis to lymph nodes. 2,3 Human podoplanin is expressed in various normal human tissues. Podoplanin is highly and specifically expressed in lymphatic endothelial cells, but not in blood vessel endothelium. 4,5...

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“…Similar results were found when SLNP alone and association of it with END were compared for diagnostic detection and sensitivities. Stoeckli (18) conducted SLNB in a T1-T2 N0 oral cavity and oropharynx study group comprising of 79 patients and performed END to patients having positive sentinel lymph node. SLNB sensitivity was found to be 98%.…”

Section: Clinical and Research Effectsmentioning

confidence: 99%

The Role of Sentinel Lymph Node Biopsy in Head and Neck Cancers and Its Application Areas

Demir

2016

Turk Arch Otorhinolaryngol

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Sentinel Node Biopsy for Oral and Oropharyngeal Squamous Cell Carcinoma of the Head and Neck

Cited by 134 publications

References 42 publications

High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

Podoplanin expression correlates with sentinel lymph node metastasis in early squamous cell carcinomas of the oral cavity and oropharynx

The Role of Sentinel Lymph Node Biopsy in Head and Neck Cancers and Its Application Areas

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