The Role of Sentinel Lymph Node Biopsy in Head and Neck Cancers and Its Application Areas

Demir, Deniz

doi:10.5152/tao.2016.1129

Cited by 5 publications

(2 citation statements)

References 31 publications

(25 reference statements)

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“…SLN is defined as the first node into which lymph enters from the primary tumor. The aim of the biopsy is to detect occult metastases -if the SLN is invaded by malignancy, the spread of the disease to other descending nodes is highly probable and block neck dissection is indicated (8).…”

Section: Nasopharynx Oropharynx and Hypopharynx Larynxmentioning

confidence: 99%

Distribution of Metastases in Ent Area – Comparison of Theory and Practice

Behanova

Pedan

Hanzel

et al. 2021

Acta Medica Martiniana

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In head and neck cancers the occurrence of nodal metastases is the most important prognostic factor. Their early diagnosis is crucial for proper treatment. Detection of early metastases is still very difficult. Predictive diagnostic methods such as the sentinel lymph node detection is limited by the occurrence of skip metastases. At our Clinic we prefer a selective neck dissection based on a surgical treatment of predilected lymphatic spread area for each type of head and neck tumor with a preservation of non-lymphatic structures of the neck. The main objective of this article is to analyze the distribution of neck metastases and to study the frequency of skip metastases in head and neck cancer.

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Section: Nasopharynx Oropharynx and Hypopharynx Larynxmentioning

confidence: 99%

Distribution of Metastases in Ent Area – Comparison of Theory and Practice

Behanova

Pedan

Hanzel

et al. 2021

Acta Medica Martiniana

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“…As an effort toward less extensive surgery, a new technique was introduced that only removes the regions of the neck that are most likely to be the site of metastasis. The sentinel node technique is regarded as an extremely selective neck dissection as it only dissects the gateway nodes (de Bree and Leemans, 2010, Demir, 2016). This is a very promising technology and it may replace the conventional elective neck dissection in the near future (Sharma et al, 2017).…”

Section: Introduction and Epidemiology Of Head And Neck Cancermentioning

confidence: 99%

Head and neck cancer management and cancer stem cells implication

Elkashty

Ashry

2019

The Saudi Dental Journal

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Head and neck squamous cell carcinomas (HNSCCs) arise in the mucosal linings of the upper aerodigestive tract and are heterogeneous in nature. Risk factors for HNSCCs are smoking, excessive alcohol consumption, and the human papilloma virus. Conventional treatments are surgery, radiotherapy, chemotherapy, or a combined modality; however, no international standard mode of therapy exists. In contrast to the conventional model of clonal evolution in tumor development, there is a newly proposed theory based on the activity of cancer stem cells (CSCs) as the model for carcinogenesis. This “CSC hypothesis” may explain the high mortality rate, low response to treatments, and tendency to develop multiple tumors for HNSCC patients. We review current knowledge on HNSCC etiology and treatment, with a focus on CSCs, including their origins, identifications, and effects on therapeutic options.

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