High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

Züllig, Lena; Roessle, Matthias; Weber, Claudia S; Graf, Nicole; Haerle, Stephan K.; Jochum, Wolfram; Stoeckli, Sandro J.; Moch, Holger; Huber, Gerhard

doi:10.1016/j.ejca.2013.01.005

Cited by 32 publications

(34 citation statements)

References 41 publications

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“…Qiao et al supported the finding that SOX2 expression was significantly associated with lymph node metastasis (100). However, the study conducted by Züllig et al showed that increased expression levels of SOX2 were significantly associated with a lack of lymph node metastasis, which implies a good prognosis in OSCC patients, and indicated that the heterogeneity of primary tumors may be one of the reasons for controversial results (79). This result is consistent with certain findings in lung cancer (101).…”

Section: Association Between Sox2 and Lymph Node Metastasissupporting

confidence: 82%

“…This result is consistent with certain findings in lung cancer (101). According to the data in the study by Züllig et al, SOX2 is a potential predictive marker for the lack of metastasis to the sentinel lymph nodes of the neck in early SCC of the oral cavity (79).…”

Section: Association Between Sox2 and Lymph Node Metastasissupporting

confidence: 81%

“…The vast majority of studies showed that the survival rate of OSCC patients possessing low levels of SOX2 is increased compared with those with high levels of SOX2. However, the opposite view was indicated by Züllig et al, who supported that low level SOX2 expression was significantly associated with worse survival (79). Additional studies are required in order to understand the conflicting opinions.…”

Section: Sox2 In Osccmentioning

confidence: 52%

“…These findings are valuable in providing useful information for developing a novel classification system and therapeutic strategies for HNSCC (64). However, the opposite viewpoint from certain studies supported that increased levels of SOX2 was significantly associated with better prognosis in the patients of OSCC and squamous cell lung cancer (69,79).…”

Section: Sox2 In Osccmentioning

confidence: 94%

“…SOX2 expression has been demonstrated to improve the ability of invasion and migration of tumor cells in tongue squamous cell carcinoma (TSCC) (77). Other properties of cancer cells in OSCC or HNSCC that involve the SOX2 protein include apoptosis (74,78), chemoresistance (79), metastasis and tumorigenesis (10,79).…”

Section: Sox2 In Osccmentioning

confidence: 99%

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Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis

Ren

Zhang

2016

Oncology Letters

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Abstract. Oral squamous cell carcinomas (OSCCs) are a growing problem in the world. The various existing treatments have not markedly improved the survival rate of patients with OSCC during the past three decades. Novel treatment strategies are required. Sex determining region Y-box 2 (SOX2) is a transcription factor that is involved in the maintenance of embryonic stem cell pluripotency and in multiple developmental processes. SOX2 expression was indicated to act as a prognostic factor in various types of tumors, including breast, colorectal, gastric and lung cancer and glioblastoma, and as a link between malignancy and stemness. Cancer stem cells (CSCs) may be responsible for the genesis, growth and metastatic spread of tumors. The poor survival outcomes for OSCC patients may be attributable to a poor selection of target cells for treatment, as current oral cancer therapies are generally aimed at the global mass of tumor. Therefore, the consideration that novel approaches to oral cancer may be targeted using SOX2 and CSCs appears reasonable. In order to better understand the oncogenic roles and the corresponding signal transduction pathways of the SOX2 protein, the present study emphasizes the role of SOX2 in OSCC, including the proteins associated with OSCC, and reviews the literature regarding the role of SOX2 in lymph node metastasis. The aim of the present study is to provide a reference for future studies that engage in research on the aforementioned subject.

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Section: Association Between Sox2 and Lymph Node Metastasissupporting

confidence: 82%

Section: Association Between Sox2 and Lymph Node Metastasissupporting

confidence: 81%

Section: Sox2 In Osccmentioning

confidence: 52%

Section: Sox2 In Osccmentioning

confidence: 94%

Section: Sox2 In Osccmentioning

confidence: 99%

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Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis

Ren

Zhang

2016

Oncology Letters

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Quantification of serum SOX2 DNA with FQ-PCR potentially provides a diagnostic biomarker for lung cancer

Xue

et al. 2013

Med Oncol

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Sex-determining region Y-box 2 (SOX2), as a subunit of transcription and reprogramming factor, plays a critical role in the development and progression of many malignancies, including lung cancer through gene amplification. In the present study, we aimed to quantify the levels of serum SOX2 DNA, analyze its diagnostic value and compare it with existing clinical parameters in lung cancer, and purpose to provide a novel tumor marker for lung cancer. Serum DNA was extracted from 94 lung cancer patients, 10 benign lung diseases, and 30 healthy volunteers, and then the levels of SOX2 DNA were quantified using real-time fluorescent quantitative polymerase chain reaction (FQ-PCR). The data were analyzed by statistical software SPSS14.0. The present results show that serum SOX2 DNA level in lung cancer group was higher compared to the levels in benign lung diseases group (u = 102.0, p < 0.001) or healthy group (u = 140.0, p < 0.001), and it was closely associated with TNM stage, histopathological type, and tumor size (p = 0.031, p = 0.012, and p = 0.010, respectively). However, serum SOX2 DNA levels of lung cancer patients were not associated with age, gender, smoking status, lymph node metastasis, or tumor differentiation (p > 0.05). ROC curve showed a sensitivity of 78.9% and a specificity of 82.5% for the ability of serum SOX2 DNA to detect lung cancer at the cutoff value of 1,078.3 copies/ul. Furthermore, we assessed the associations of serum SOX2 levels with clinical existing lung tumor markers, such as squamous cell carcinoma antigen, cytokeratin fragment 21-1, and neuron-specific enolase. The sensitivity was increased from 24.9, 66.1, and 39.1 to 84.2, 92.8, and 87.5%, respectively, by the combination of serum SOX2 DNA. Taken together, quantification of serum SOX2 DNA by FQ-PCR may serve as a novel accessory diagnostic tool for the clinical screening and detection of lung cancer.

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Combined class I histone deacetylase and mTORC1/C2 inhibition suppresses the initiation and recurrence of oral squamous cell carcinomas by repressing SOX2

et al. 2019

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High sex determining region Y-box 2 expression is a negative predictor of occult lymph node metastasis in early squamous cell carcinomas of the oral cavity

Cited by 32 publications

References 41 publications

Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis

Expression of SOX2 in oral squamous cell carcinoma and the association with lymph node metastasis

Quantification of serum SOX2 DNA with FQ-PCR potentially provides a diagnostic biomarker for lung cancer

Combined class I histone deacetylase and mTORC1/C2 inhibition suppresses the initiation and recurrence of oral squamous cell carcinomas by repressing SOX2

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