Sentence comprehension in ageing and Alzheimer's disease

Boxtel, Willem S. van; Lawyer, Laurel A.

doi:10.1111/lnc3.12430

Cited by 13 publications

(3 citation statements)

References 81 publications

(129 reference statements)

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“…Sung et al [64] found a significant effect of word order; canonical sentences were better comprehended than sentences with syntactic movement. Similar findings were also found in other studies (e.g., [65‒67]). In the current study, the older adult participants were tested using a syntactic production task.…”

Section: Introductionsupporting

confidence: 92%

Language in Healthy Ageing: A Comparison across Language Domains

Biran

Gvion

Shmuely-Samuel

2022

Folia Phoniatr Logop

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Introduction: Life expectancy has been increasing in recent decades. Therefore, it is important to understand the functional changes during healthy ageing. Most research has mainly focused on one linguistic domain at a time. The current study aimed at investigating whether changes in language performance in healthy ageing occur in some language domains more than in others. Methods: Twenty-three older healthy Hebrew-speaking adults, exhibiting no cognitive decline, were examined on tasks aimed at testing their performance in different language and cognitive domains: lexical retrieval, complementation information, syntax, Theory of Mind (a domain related to pragmatic aspects of language) and short-term memory. We compared their performance at both the group and the individual levels. Comparisons were made between the performance of the older adults and control data of young adults, and between the older adults' performance in the different linguistic domains. In addition, correlations between the older adults' phonological short-term memory abilities and their performance in various linguistic domains were examined. Results: A decline was found in several linguistic domains among the older adults, while in other domains no decline was found. However, no unequivocal decline in linguistic functioning was found due to relatively large variance in their performance. Conclusion: Not all linguistic domains are equally vulnerable in ageing, and not all older adults are equally affected. The research has both clinical and theoretical implications.

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Section: Introductionsupporting

confidence: 92%

Language in Healthy Ageing: A Comparison across Language Domains

Biran

Gvion

Shmuely-Samuel

2022

Folia Phoniatr Logop

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“…Our approach, being in line with most neurocognitive instrument scoring guidelines which score examinees’ answers as either correct or false, may bypass potential bias stemming from the complex interplay between personality traits, non-cognitive symptoms of neurocognitive disorders (e.g., impulsivity) and cognitive and functional performance (Rouch et al 2019 ; Sakurai et al 2020 ; Cerni et al 2021 ; Giannakis et al 2021 ). Furthermore, it may be reckoned that differences in the length of questions of the two here studied auditory stimuli-based dysnomia instruments may have biased our observations since individuals with cognitive impairment face difficulties in understanding long sentences (van Boxtel and Lawyer 2021 ). In such a case, low performance on WoFi and WoFi-brief may be attributed not only to dysnomia but also to comprehension difficulties.…”

Section: Discussionmentioning

confidence: 99%

Validation of the test for finding word retrieval deficits (WoFi) in detecting Alzheimer's disease in a naturalistic clinical setting

Georgiou,

Skondra,

Charalampopoulou

et al. 2023

Eur J Ageing

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Background Detecting impaired naming capacity contributes to the detection of mild (MildND) and major (MajorND) neurocognitive disorder due to Alzheimer’s disease (AD). The Test for Finding Word retrieval deficits (WoFi) is a new, 50-item, auditory stimuli-based instrument. Objective The study aimed to adapt WoFi to the Greek language, to develop a short version of WoFi (WoFi-brief), to compare the item frequency and the utility of both instruments with the naming subtest of the widely used Addenbrooke’s cognitive examination III (ACEIIINaming) in detecting MildND and MajorND due to AD. Methods This cross-sectional, validation study included 99 individuals without neurocognitive disorder, as well as 114 and 49 patients with MildND and MajorND due to AD, respectively. The analyses included categorical principal components analysis using Cramer’s V, assessment of the frequency of test items based on corpora of television subtitles, comparison analyses, Kernel Fisher discriminant analysis models, proportional odds logistic regression (POLR) models and stratified repeated random subsampling used to recursive partitioning to training and validation set (70/30 ratio). Results WoFi and WoFi-brief, which consists of 16 items, have comparable item frequency and utility and outperform ACEIIINaming. According to the results of the discriminant analysis, the misclassification error was 30.9%, 33.6% and 42.4% for WoFi, WoFi-brief and ACEIIINaming, respectively. In the validation regression model including WoFi the mean misclassification error was 33%, while in those including WoFi-brief and ACEIIINaming it was 31% and 34%, respectively. Conclusions WoFi and WoFi-brief are more effective in detecting MildND and MajorND due to AD than ACEIIINaming.

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“…However, reduced syntactic complexity, morphosyntactic impairment, as well as phonetic and phonological manifestations have been documented in AD (Ahmed et al, 2012;Cera et al, 2018;Fyndanis et al, 2018). Linguistic deficits in AD have been commonly linked to working memory impairment and decreased processing speed (Jokel et al, 2019;Boxtel and Lawyer, 2021).…”

Section: Introductionmentioning

confidence: 99%

Comparing Individuals With PPA to Individuals With AD: Cognitive and Linguistic Profiles

Karpathiou

Kambanaros

2022

Front. Commun.

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Primary Progressive Aphasia (PPA) is a degenerative condition characterized by the progressive loss of language function. In PPA, aphasia is the most prominent deficit at onset. On the other hand, memory deficits are the hallmark of Alzheimer's disease (AD). The first aim of the study was to establish differences on neuropsychological testing and connected speech production between Greek-speaking individuals with AD and PPA. The second aim was to investigate the executive deficit involvement in the two conditions. Ten individuals with PPA and 9 individuals with AD took part in a comprehensive cognitive-linguistic evaluation. Fifteen demographically matched neurologically healthy adults served as controls. Participants were evaluated using a battery of neuropsychological measures. Quantitative production analysis and acoustic analysis were performed to calculate narrative and temporal measures of the participants' speech. Participants with PPA differed significantly from participants with AD on linguistic measures. They performed worse on the long frequent sentences' subtest of the Sentence Repetition Test and they produced fewer narrative and unique words in picture description. They also produced shorter, less elaborated sentences, and made more phonological errors. The two groups did not differ significantly on memory, executive, visuospatial and semantic composite measures. Compared to neurotypical adults, participants with AD were impaired in memory, and executive function. They also exhibited lexical retrieval difficulties, as well as difficulties in linguistic tasks with an increased processing load. Participants with PPA performed within normal limits on the delay conditions of episodic memory measures. However, they too were impaired in executive tasks, especially for short-term memory and verbal fluency. The production of phonological errors, difficulty in repeating long frequent sentences, and the production of simple and short sentences has differentiated participants PPA not only from neurotypical controls but also from participants with AD. No single measure could differentiate the AD group from the other two groups. These findings should be interpreted with caution considering the small sample size.

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Sentence comprehension in ageing and Alzheimer's disease

Cited by 13 publications

References 81 publications

Language in Healthy Ageing: A Comparison across Language Domains

Language in Healthy Ageing: A Comparison across Language Domains

Validation of the test for finding word retrieval deficits (WoFi) in detecting Alzheimer's disease in a naturalistic clinical setting

Comparing Individuals With PPA to Individuals With AD: Cognitive and Linguistic Profiles

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